1-(7-chloro-4-(1,3-diaminopropyl)quinolyl)-2-(10β-dihydroartemisinoxy)ethyl dimer | 1259553-34-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-(7-chloro-4-(1,3-diaminopropyl)quinolyl)-2-(10β-dihydroartemisinoxy)ethyl dimer
• 英文别名: N-(7-chloroquinolin-4-yl)-N',N'-bis[2-[[(1R,4S,5R,8S,9R,10S,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]oxy]ethyl]propane-1,3-diamine
• CAS: 1259553-34-8
• 化学式: C₄₆H₆₆ClN₃O₁₀
• 分子量: 856.497
• InChiKey: DGLWXPQDRLJTLE-POTOUGMZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.8
• 重原子数：
  60
• 可旋转键数：
  13
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  N-(7-chloroquinolin-4-yl)propane-1,3-diamine 、 2-(10β-dihydroartemisinoxy)propyl bromide 以 N,N-二甲基甲酰胺 为溶剂， 以20%的产率得到1-(7-chloro-4-(1,3-diaminopropyl)quinolyl)-2-(10β-dihydroartemisinoxy)ethyl dimer
  参考文献：
  名称：

  Artemisinin–quinoline hybrid-dimers: Synthesis and in vitro antiplasmodial activity

  摘要：

  Novel artemisinin-quinoline hybrid-dimers were synthesized from dihydroartemisinin and different aminoquinolines at elevated temperatures (90-110 degrees C). All compounds were obtained as the beta-isomers and were tested against both chloroquine sensitive and resistant strains of Plasmodium falciparum. Hybrid-dimer 8 showed the highest antiplasmodial activity, inheriting the optimum chain length of three carbon atoms. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.09.130

文献信息

• Artemisinin–quinoline hybrid-dimers: Synthesis and in vitro antiplasmodial activity
  作者：Marli C. Lombard、David D. N’Da、Jaco C. Breytenbach、Peter J. Smith、Carmen A. Lategan

  DOI：10.1016/j.bmcl.2010.09.130

  日期：2010.12

  Novel artemisinin-quinoline hybrid-dimers were synthesized from dihydroartemisinin and different aminoquinolines at elevated temperatures (90-110 degrees C). All compounds were obtained as the beta-isomers and were tested against both chloroquine sensitive and resistant strains of Plasmodium falciparum. Hybrid-dimer 8 showed the highest antiplasmodial activity, inheriting the optimum chain length of three carbon atoms. (C) 2010 Elsevier Ltd. All rights reserved.