(+/-)-1-methyl-4-isopropyl-bicyclo[2.2.2]octene-(5)-dicarboxylic acid-(2endo.3endo) | 50729-73-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (+/-)-1-methyl-4-isopropyl-bicyclo[2.2.2]octene-(5)-dicarboxylic acid-(2endo.3endo)
• 英文别名: (+/-)-1-Methyl-4-isopropyl-bicyclo[2.2.2]octen-(5)-dicarbonsaeure-(2endo.3endo)；(1R,2R,3S,4R)-1-methyl-4-propan-2-ylbicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic acid
• CAS: 50729-73-2
• 化学式: C₁₄H₂₀O₄
• 分子量: 252.31
• InChiKey: NUSINLKEHOLCPD-GIFSMMMISA-N

物化性质

• 沸点：
  411.1±45.0 °C(Predicted)
• 密度：
  1.246±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (+/-)-1-methyl-4-isopropyl-bicyclo[2.2.2]octene-(5)-dicarboxylic acid-(2endo.3endo) 、 水 、 溴 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Diels; Koch; Frost, Chemische Berichte, 1938, vol. 71, p. 1163,1167

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium carbonate 作用下， 生成 (+/-)-1-methyl-4-isopropyl-bicyclo[2.2.2]octene-(5)-dicarboxylic acid-(2endo.3endo)
  参考文献：
  名称：

  Diels; Koch; Frost, Chemische Berichte, 1938, vol. 71, p. 1163,1167

  摘要：

  DOI：

文献信息

• Studies in the Terpene Series. I. Dehydration of Alcohols in the Terpene Series Under Pressure and in the Presence of Dilute Aqueous Salt Solutions
  作者：V. N. Ipatieff、Herman Pines

  DOI：10.1021/ja01235a019

  日期：1944.7
• Diels; Koch; Frost, Chemische Berichte, 1938, vol. 71, p. 1163,1167
  作者：Diels、Koch、Frost

  DOI：——

  日期：——
• Horizontal resistance insolanum tuberosum to colorado potato beetle (leptinotarsa decemlineata say)
  作者：David G. Fisher、Kenneth L. Deahl、Maxwell V. Rainforth

  DOI：10.1007/bf02986361

  日期：2002.7

  Horizontal resistance (HR) was assessed as a strategy to reduce potato defoliation by the Colorado potato beetle (CPB). Hybrids among Solanum tuberosum varieties grown in Iowa were first evaluated with a detached leaflet feeding bioassay. Beginning in 1998, resistance was increased annually over three years by intermating and selecting the most resistant 1%-2% of each generation of 300-400 plants using the bioassay. When C (= mg leaf tissue consumed. neonate larva(-1) over 48 h) was measured for the 1% most-resistant genotypes of all generations grown side by side in 2000, it ranged from 6.1 mg (*) larva(-1) in the parents to 2.3 for progeny of the F(3) generation compared to 2.7 in ND2858-1, a resistant check. Field trials in Wisconsin showed less defoliation in the F(1) and F(2) selected genotypes than in the parents. A second breeding program using more S. tuberosum parents with greater genetic diversity, and much larger breeding populations, resulted in significantly faster accumulation of resistance, further suggesting that recurrent mass selection is effective. Foliar glycoalkaloid analyses revealed low levels of solanine and chaconine in the F(3) selections; no leptines or leptinines were detected. Because the parents were S. tuberosum varieties in which vertical resistance to CPB is unknown, and because the resistance to feeding from parents to the F(3) resistant plants was linear and gradual while ranging from initially very low to considerably higher in the third year, horizontal resistance is strongly implicated. The development of a significant degree of resistance after three rounds of breeding using relatively small breeding populations suggests that HR can be developed from varieties of Solanum tuberosum lacking initial high levels of resistance to CPB.