6-氯-3-吲哚基-Α-D-吡喃半乳糖苷 | 198402-61-8

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6-氯-3-吲哚基-Α-D-吡喃半乳糖苷
• 英文名称: 6-Chloro-3-indolyl alpha-D-galactopyranoside
• 英文别名: (2R,3R,4S,5R,6R)-2-[(6-chloro-1H-indol-3-yl)oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 198402-61-8
• 化学式: C₁₄H₁₆ClNO₆
• 分子量: 329.73
• InChiKey: OQWBAXBVBGNSPW-HTOAHKCRSA-N

物化性质

• 沸点：
  630℃
• 密度：
  1.641
• 闪点：
  335℃

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  115
• 氢给体数：
  5
• 氢受体数：
  6

安全信息

• WGK Germany：
  3
• 海关编码：
  29400090

文献信息

• [EN] CHROMOGENIC SUBSTRATES FOR BETA-D-GLUCURONIDASE ACTIVITY AND USE THEREOF FOR MICROBIAL DETECTION<br/>[FR] SUBSTRATS CHROMOGENES POUR L'ACTIVITE DE LA BETA-D-GLUCURONIDASE, ET UTILISATION DE CEUX-CI A DES FINS DE DETECTION MICROBIENNE
  申请人：GLYCOSYNTH LTD

  公开号：WO2015067926A1

  公开（公告）日：2015-05-14

  Chromogenic substrates for β-D-glucuronidase activity comprising monoglucuronides of some 1,2-dihydroxyaromatic derivatives. When cleaved these form soluble coloured conjugates with multivalent metal ions such as iron ions. The substrates may be used in conjunction with chromogenic substrates for other enzymes in microbial detection and identification especially involving liquid media. Microbes can be grown in the presence of the substrates and the compounds providing the metal ion. The substrates are particularly useful for detecting β-D-glucuronidase-positive E. coli. Some of the substrates are new compounds, these having the formula II: wherein X2 is independently selected from the group consisting of H, CH3, C2-C6 alkyl, a metal cation and a non-metal cation; wherein Y2 is independently selected from the group consisting of H, a metal cation and a non-metal cation; wherein R21 is H; wherein R24 is H or NO2; and wherein R22 and R23 are H or one is OH and the other is H, or R22 and R23 together form the group VII: -CR25=CR26-CR27=CR28- VII; wherein R25 to R28 are independently selected from H, OH, C1-C8 alkyl, C1- C8 alkoxy, C1-C8 hydroxyalkyl, halogen, nitro, C2-C24 acyl, C2-C24 acyloxy, C7-C24 aralkyl, C6-C24 aryl, sulfonyl and amido, provided that any vicinal groups R25-R28 are not both OH. Synthetic methods for making the compounds are described.

  β-D-葡萄糖苷酶活性的显色底物包括一些1,2-二羟基芳香衍生物的单葡萄糖醛酸酯。当被裂解时，这些底物会与多价金属离子（如铁离子）形成可溶的有色结合物。这些底物可以与微生物检测和鉴定中的其他酶的显色底物一起使用，尤其涉及液体培养基。微生物可以在存在这些底物和提供金属离子的化合物的情况下生长。这些底物特别适用于检测β-D-葡萄糖苷酶阳性的大肠杆菌。其中一些底物是新化合物，其化学式为II：其中X2独立选择自H、CH3、C2-C6烷基、金属阳离子和非金属阳离子组成；Y2独立选择自H、金属阳离子和非金属阳离子组成；R21为H；R24为H或NO2；R22和R23为H或其中一个为OH，另一个为H，或者R22和R23一起形成组VII：-CR25=CR26-CR27=CR28- VII；R25至R28独立选择自H、OH、C1-C8烷基、C1-C8烷氧基、C1-C8羟基烷基、卤素、硝基、C2-C24酰基、C2-C24酰氧基、C7-C24芳基烷基、C6-C24芳基、磺酰基和酰胺，前提是任何相邻的基团R25-R28均不是两个都是OH。描述了制备这些化合物的合成方法。
• BIOSENSORS UTILIZING INK JET-PRINTED BIOMOLECULE COMPATIBLE SOL GEL INKS AND USES THEREOF
  申请人：Brennan John D.

  公开号：US20120135437A1

  公开（公告）日：2012-05-31

  Novel solid-phase biosensors that utilize ink jet printing of biocompatible sol-gel based inks to create sensor strips are reported herein. Biomolecules and other reagents useful in bioassays to detect, for example, pathogenic microorganisms or toxic substances, are immobilized on a substrate, which can be paper based, by layering these substances between two layers of biomolecule compatible sol gel. The sol gel precursor solutions and solutions of the assay reagents are printed from separate nozzles in a layered approach which avoids clogging of the nozzles by the pre-mature gelling of the sol gel precursor solution. In certain embodiments of the application, a capture agent is used to concentrate a compound to be detected in specific areas on the substrate to facilitate detection.

  本文报道了利用喷墨打印生物相容性溶胶凝胶基墨水制作传感器条的新型固相生物传感器。生物分子和其他有用于生物测定的试剂，例如用于检测病原微生物或有毒物质，被固定在基底上（可以是纸张），通过在两层生物分子相容性溶胶凝胶之间堆叠这些物质来实现。溶胶凝胶前体溶液和生物测定试剂的溶液从分离的喷嘴中以分层的方式打印，避免了溶胶凝胶前体溶液过早凝胶导致喷嘴堵塞的问题。在本申请的某些实施例中，使用捕获剂将待检化合物浓缩在基底的特定区域，以便于检测。
• Medium for detecting and differentiating vancomycin-resistant enterococci
  申请人：OXOID LIMITED

  公开号：EP2186906A2

  公开（公告）日：2010-05-19

  A medium for the growth of vancomycin-resistant Enterococci comprising:- (i) a nutrient medium with an energy source effective to support growth and reproduction of vancomycin-resistant Enterococci; (ii) an effective amount of one or more selective agents to inhibit the growth of microorganisms other than vancomycin-resistant Enterococci; (iii) a Krebs cycle intermediate.

  一种用于耐万古霉素肠球菌生长的培养基，包括 (i) 营养培养基，其中含有有效支持耐万古霉素肠球菌生长和繁殖的能量源； (ii) 一种或多种抑制耐万古霉素肠球菌以外的微生物生长的有效量的选择性制剂； (iii) 克雷布斯循环中间体。
• Novel indicator platform
  申请人：Biosynth AG

  公开号：EP2256103A1

  公开（公告）日：2010-12-01

  A novel indicator platform comprises a plurality of 1H-Indol-3-yl indicator compounds that are capable of converting to a signalophore compound in response to an external stimulus. In one class of indicator compounds, the resulting signalophores are 2-benzylideneindoline compounds that are formed by an intermolecular Aldol-type process; in a further class of indicator compounds, the resulting signalophores are 10H-indolo[1,2-a]indole compounds that are formed by an intramolecular Aldol-type process. The indicators can be used in a wide array of applications relating, for example, to biological systems or optical data storage.

  一种新型指示剂平台由多种 1H-吲哚-3-基指示剂化合物组成，这些化合物能够在外部刺激下转化为信号团化合物。在一类指示剂化合物中，产生的信号团是通过分子间醛醇型过程形成的 2-亚苄基吲哚啉化合物；在另一类指示剂化合物中，产生的信号团是通过分子内醛醇型过程形成的 10H-吲哚并[1,2-a]吲哚化合物。这些指示剂可广泛应用于生物系统或光学数据存储等领域。
• Test media and quantitative or qualitative method for identification and differentiation of biological materials in a test sample
  申请人：Micrology Laboratories L.L.C.

  公开号：EP2316964A1

  公开（公告）日：2011-05-04

  A test medium and method for detecting, quantifying, identifying and differentiating up to four (4) separate biological materials in a test sample. A test medium is disclosed which allows quantifying and differentiating under ambient light aggregates of biological entities producing specific enzymes, which might include general coliforms, E. coli, Aeromonas, and Salmonella in a single test medium. A new class of nonchromogenic substrates is disclosed which produce a substantially black, non-diffusible precipitate. This precipitate is not subject to interference from other chromogenic substrates present in the test medium.; In one embodiment, the substrates are selected such that E. coli colonies present in the test medium show as substantially black, general coliforms colonies show in the test medium as a blue-violet color, Aeromonas colonies present in the test medium show as a generally red-pink color, and Salmonella colonies show as a generally teal-green color. Other microorganisms and color possibilities for detection and quantification thereof are also disclosed. An inhibitor and method for making a test medium incorporating the inhibitor are disclosed.

  一种检测介质和方法，用于检测、量化、识别和区分检测样本中多达四（4）种不同的生物材料。本发明公开了一种测试介质，可在环境光下对产生特定酶的生物实体聚集体进行定量和区分，这些生物实体可能包括单个测试介质中的普通大肠菌群、大肠杆菌、气单胞菌和沙门氏菌。公开了一类新的非变色基质，这种基质会产生一种黑色的、不可扩散的沉淀物。在一个实施方案中，基质的选择是这样的：存在于测试培养基中的大肠杆菌菌落显示为黑色，一般大肠菌群菌落显示为蓝紫色，存在于测试培养基中的气单胞菌菌落显示为粉红色，沙门氏菌菌落显示为茶绿色。此外，还公开了其他微生物及其检测和定量的颜色可能性。此外，还公开了一种抑制剂和制作含有该抑制剂的测试培养基的方法。