α-Monoricinolein | 1323-38-2

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: α-Monoricinolein
• 英文别名: Glyceryl ricinoleate；2,3-Dihydroxypropyl 12-hydroxy-9-octadecenoate；2,3-dihydroxypropyl (E)-12-hydroxyoctadec-9-enoate
• CAS: 1323-38-2
• 化学式: C₂₁H₄₀O₅
• 分子量: 372.546
• InChiKey: HDIFHQMREAYYJW-FMIVXFBMSA-N

物化性质

• 密度：
  0.99-1.01 g/cm3(Temp: 15 °C)
• LogP：
  4.713 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (2,2-dimethyl-1,3-dioxolan-4-yl)methyl (E)-12-[tert-butyl(dimethyl)silyl]oxyoctadec-9-enoate 、 三氟化硼 、 乙醚 、 二氯甲烷 生成 α-Monoricinolein
  参考文献：
  名称：

  FROLING, A., CHEM. AND PHYS. LIPIDS, 53,(1990) N, C. 289-308

  摘要：

  DOI：

文献信息

• Compositions and methods for inhibiting HMGB1 activation of melanocytes
  申请人：The Procter & Gamble Company

  公开号：US10054582B2

  公开（公告）日：2018-08-21

  A method of identifying a test agent as a skin tone agent. The method includes determining the level of high-mobility group protein B1 (HMGB1), messenger RNA associated with the expression and/or regulation of HMGB1 (HMGB1 mRNA), and/or micro-RNA associated with the expression and/or regulation of HMGB1 (HMGB1 miRNA) present in the test sample, and identifying the test agent as a skin tone agent when there is no increase in HMGB1 level, a downregulation in transcription of HMGB1 mRNA, and/or an upregulation of HMGB1 miRNA. The method also includes identifying a test agent as a skin tone agent when the test agent inhibits or prevents an increase in melanocyte dendricity and/or body size caused by HMGB1.

  一种将测试剂鉴定为肤色剂的方法。该方法包括确定测试样本中存在的高迁移率基团蛋白 B1 (HMGB1)、与 HMGB1 的表达和/或调节相关的信使 RNA (HMGB1 mRNA)、和/或与 HMGB1 的表达和/或调节相关的微 RNA (HMGB1 miRNA)的水平，当 HMGB1 水平没有增加、HMGB1 mRNA 的转录下调和/或 HMGB1 miRNA 上调时，确定测试剂为肤色剂。该方法还包括当测试剂抑制或防止 HMGB1 引起的黑素细胞树突性和/或体型增加时，将测试剂鉴定为肤色剂。
• METHOD OF MAKING A SKIN CARE COMPOSITION
  申请人：The Procter & Gamble Company

  公开号：EP3191192B1

  公开（公告）日：2019-11-06
• METHODS FOR INHIBITING HMGB1 ACTIVATION OF MELANOCYTES, METHOD FOR IDENTIFICATION OF AGENTS SUITABLE FOR SUCH INHIBITON
  申请人：The Procter & Gamble Company

  公开号：EP3191839B1

  公开（公告）日：2019-07-24
• LIQUID FRAGRANCE COMPOSITIONS
  申请人：International Flavors & Fragrances Inc.

  公开号：EP3826606A1

  公开（公告）日：2021-06-02
• USE OF NANODISPERSIONS TO PROTECT WATER-SOLUBLE INGREDIENTS IN COSMETIC END FORMULATIONS
  申请人：Mongiat Sébastien

  公开号：US20120093896A1

  公开（公告）日：2012-04-19

  The invention describes the use of a nanodispersion, which comprises: a) a membrane-forming molecule, b) a co-emulsifier, c) a lipophilic component, and d) a water-soluble ingredient sensitive to oxidation in cosmetic end formulations, the nanodispersion being obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous liquid is obtained (so-called nanodispersion pre-phase), and (β) adding the water or aqueous phase (discontinuous phase) which contains the water-soluble ingredient and optionally the non-aqueous polar organic solvent to the liquid obtained in step (α). Component (d) is preferably ascorbic acid or vitamin C.