(2S,6R,7S)-6-chloro-9-[3-(2-oxo-4,5-diphenyl-1,3-oxazol-3-yl)propyl]-2-[(4-phenylmethoxyphenyl)methyl]-4-oxa-1,8-diazabicyclo[5.3.1]undec-8-en-10-one | 183794-56-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (2S,6R,7S)-6-chloro-9-[3-(2-oxo-4,5-diphenyl-1,3-oxazol-3-yl)propyl]-2-[(4-phenylmethoxyphenyl)methyl]-4-oxa-1,8-diazabicyclo[5.3.1]undec-8-en-10-one
• CAS: 183794-56-1
• 化学式: C₄₀H₃₈ClN₃O₅
• 分子量: 676.212
• InChiKey: YQNKRIJUUZRALV-MTFQNXCDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  49
• 可旋转键数：
  11
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  80.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2S,6R,7S)-6-chloro-9-[3-(2-oxo-4,5-diphenyl-1,3-oxazol-3-yl)propyl]-2-[(4-phenylmethoxyphenyl)methyl]-4-oxa-1,8-diazabicyclo[5.3.1]undec-8-en-10-one 在 lithium hydroxide 、 sodium tetrahydroborate 、 碳酸氢钠 、 sodium iodide 作用下， 以 四氢呋喃 、 甲醇 、 丙酮 为溶剂， 生成 (S)-2-{(2S,6R,7S,9S)-2-(4-Benzyloxy-benzyl)-10-oxo-9-[3-(2-oxo-4,5-diphenyl-oxazol-3-yl)-propyl]-4-oxa-1,8-diaza-bicyclo[5.3.1]undec-6-ylamino}-3-(1H-indol-3-yl)-propionic acid
  参考文献：
  名称：

  Formation of the 7-Oxa-1,4,10-triazatricyclo[8.2.2^5,12]tetradecane-2,14-dione Ring System:  Misrouted Synthesis of a Peptidomimetic

  摘要：

  An attempted synthesis of the tricyclic peptidomimetic 1, designed to imitate a beta-turn tripeptide in tendamistat, afforded instead the 6,6,8-ring system of 2, The key step in the synthesis entailed acylation of the hindered alpha,alpha'-disubstituted morpholine 4.2, which was approached by acylative ring opening of the 3,6-oxazabicyclo[4.2.0]octane 4.3. However, transannular rather than exocyclic cleavage occurred, giving the 1,6-oxazacyclooctane isomer 4.5. Subsequent ring closures to form the bi- and tricyclic intermediates 7.3 and 8.5 were difficult because of the strain being built into the ring systems. After completion of the synthesis, the structures of the intermediates and final product were elucidated by NMR, with three-bond, heteronuclear multiple-bond correlation experiments providing unambiguous evidence for the ring connectivity, and by molecular modeling, which allowed assignment of the stereochemistry. Compound 2 is a modest inhibitor of the target enzyme alpha-amylase (K-i = 170 mu M in 5% DMSO/water), binding with similar affinity to the tripeptide Ac-Trp-Arg-Tyr-OMe. Although the side-chain attachment points in the ring system of 2 correspond closely to the relative C alpha-positions in tendamistat (rmsd = 0.24 Angstrom), the alignment of the C alpha-C beta bonds is poor, illustrating the importance of side-chain orientation in a peptidomimetic.

  DOI：

  10.1021/jo961114p
• 作为产物：
  描述：

  Boc-L-鸟氨酸 在 lithium hydroxide 、 sodium tetrahydroborate 、 氯化亚砜 、 五氯化磷 、 四甲基氢氧化铵 、 四丁基氟化铵 、 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 反应 36.75h， 生成 (2S,6R,7S)-6-chloro-9-[3-(2-oxo-4,5-diphenyl-1,3-oxazol-3-yl)propyl]-2-[(4-phenylmethoxyphenyl)methyl]-4-oxa-1,8-diazabicyclo[5.3.1]undec-8-en-10-one
  参考文献：
  名称：

  Formation of the 7-Oxa-1,4,10-triazatricyclo[8.2.2^5,12]tetradecane-2,14-dione Ring System:  Misrouted Synthesis of a Peptidomimetic

  摘要：

  An attempted synthesis of the tricyclic peptidomimetic 1, designed to imitate a beta-turn tripeptide in tendamistat, afforded instead the 6,6,8-ring system of 2, The key step in the synthesis entailed acylation of the hindered alpha,alpha'-disubstituted morpholine 4.2, which was approached by acylative ring opening of the 3,6-oxazabicyclo[4.2.0]octane 4.3. However, transannular rather than exocyclic cleavage occurred, giving the 1,6-oxazacyclooctane isomer 4.5. Subsequent ring closures to form the bi- and tricyclic intermediates 7.3 and 8.5 were difficult because of the strain being built into the ring systems. After completion of the synthesis, the structures of the intermediates and final product were elucidated by NMR, with three-bond, heteronuclear multiple-bond correlation experiments providing unambiguous evidence for the ring connectivity, and by molecular modeling, which allowed assignment of the stereochemistry. Compound 2 is a modest inhibitor of the target enzyme alpha-amylase (K-i = 170 mu M in 5% DMSO/water), binding with similar affinity to the tripeptide Ac-Trp-Arg-Tyr-OMe. Although the side-chain attachment points in the ring system of 2 correspond closely to the relative C alpha-positions in tendamistat (rmsd = 0.24 Angstrom), the alignment of the C alpha-C beta bonds is poor, illustrating the importance of side-chain orientation in a peptidomimetic.

  DOI：

  10.1021/jo961114p

文献信息

• Formation of the 7-Oxa-1,4,10-triazatricyclo[8.2.2^5,12]tetradecane-2,14-dione Ring System:  Misrouted Synthesis of a Peptidomimetic
  作者：Marisa C. Kozlowski、Paul A. Bartlett

  DOI：10.1021/jo961114p

  日期：1996.1.1

  An attempted synthesis of the tricyclic peptidomimetic 1, designed to imitate a beta-turn tripeptide in tendamistat, afforded instead the 6,6,8-ring system of 2, The key step in the synthesis entailed acylation of the hindered alpha,alpha'-disubstituted morpholine 4.2, which was approached by acylative ring opening of the 3,6-oxazabicyclo[4.2.0]octane 4.3. However, transannular rather than exocyclic cleavage occurred, giving the 1,6-oxazacyclooctane isomer 4.5. Subsequent ring closures to form the bi- and tricyclic intermediates 7.3 and 8.5 were difficult because of the strain being built into the ring systems. After completion of the synthesis, the structures of the intermediates and final product were elucidated by NMR, with three-bond, heteronuclear multiple-bond correlation experiments providing unambiguous evidence for the ring connectivity, and by molecular modeling, which allowed assignment of the stereochemistry. Compound 2 is a modest inhibitor of the target enzyme alpha-amylase (K-i = 170 mu M in 5% DMSO/water), binding with similar affinity to the tripeptide Ac-Trp-Arg-Tyr-OMe. Although the side-chain attachment points in the ring system of 2 correspond closely to the relative C alpha-positions in tendamistat (rmsd = 0.24 Angstrom), the alignment of the C alpha-C beta bonds is poor, illustrating the importance of side-chain orientation in a peptidomimetic.