苯(甲)醛,4-(1H-吲哚-5-基)- | 105373-75-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 苯(甲)醛,4-(1H-吲哚-5-基)-
• 中文别名: 2,6,10,14-四甲基十五烷醛
• 英文名称: 2,6,10,14-tetramethylpentadecanal
• 英文别名: Pristanal
• CAS: 105373-75-9
• 化学式: C₁₉H₃₈O
• 分子量: 282.51
• InChiKey: IZJRIIWUSIGEAJ-UHFFFAOYSA-N

物化性质

• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  苯(甲)醛,4-(1H-吲哚-5-基)- 在 titanium(III) chloride 、 lithium 作用下， 以 乙二醇二甲醚 为溶剂， 反应 20.0h， 以59%的产率得到2,6,10,14,17,21,25,29-Octamethyl-15-triacontene
  参考文献：
  名称：

  Efficient synthesis of a head-to-head isoprenoid geochemical biomarker from phytol

  摘要：

  DOI：

  10.1021/jo00376a082
• 作为产物：
  描述：

  3,7,11,15-tetramethylhexadecane-1,2-diol 在 碘 、 mercury(II) oxide 作用下， 以 二氯甲烷 为溶剂， 以85%的产率得到苯(甲)醛,4-(1H-吲哚-5-基)-
  参考文献：
  名称：

  Efficient synthesis of a head-to-head isoprenoid geochemical biomarker from phytol

  摘要：

  DOI：

  10.1021/jo00376a082

文献信息

• [EN] EXTERNAL PREPARATION FOR SKIN<br/>[FR] PREPARATION EXTERNE POUR LA PEAU
  申请人：SHOWA DENKO KK

  公开号：WO2005094777A1

  公开（公告）日：2005-10-13

  The present invention provides an external preparation for skin, which comprises a multi-branched polysaccharide derivative with multi-branched polysaccharide skeleton consisting of saccharides as constituent units, wherein at least one of hydroxyl (OH) groups in the multi-branched polysaccharide skeleton is substituted by OR (wherein R represents a hydrogen atom, a hydrocarbon having 1 to 30 carbon groups or a hydrocarbon having 1 to 30 carbon groups which has hetero atom), which can give moisture and turgor to the skin, and cosmetics containing the external preparation.

  本发明提供了一种用于皮肤的外用制剂，其包括一种多支链多糖衍生物，该多支链多糖骨架由糖组成的多支链多糖骨架组成，其中多支链多糖骨架中的至少一个羟基（OH）被取代为OR（其中R代表氢原子、具有1至30个碳基团的碳氢化合物或具有1至30个碳基团的碳氢化合物，其具有杂原子），可以为皮肤提供水分和弹性，并且含有该外用制剂的化妆品。
• [EN] TOPICAL SLIMMING PREPARATION AND A COSMETIC CONTAINING A CARNITINE DERIVATIVE<br/>[FR] PRÉPARATION EXTERNE POUR L'AMINCISSEMENT DE LA PEAU ET PRODUIT COSMÉTIQUE CONTENANT CETTE PRÉPARATION
  申请人：SHOWA DENKO KK

  公开号：WO2005115326A1

  公开（公告）日：2005-12-08

  The invention provides a slimming skin external preparation and a cosmetic that contain a carnitine derivative having excellent skin affinity and percutaneous absorption properties and capable of enhancing the fat metabolism, and that can treat, reduce or prevent the obesity by functioning as a lipolytic agent to enhance the fat metabolism of general or local subcutaneous fat tissues. The slimming skin external preparation contains a particular carnitine derivative such as a cylcarnitines and alcohol carnitine esters and preferably other slimming and skin-care ingredients.

  本发明提供了一种减肥皮肤外用制剂和化妆品，其中包含一种肉碱衍生物，具有优异的皮肤亲和性和经皮吸收性能，能够增强脂肪代谢，并且能够作为脂肪分解剂，促进一般或局部皮下脂肪组织的脂肪代谢，从而治疗、减少或预防肥胖。该减肥皮肤外用制剂包含特定的肉碱衍生物，如环肉碱和醇肉碱酯，并且最好还包含其他减肥和护肤成分。
• [EN] HYDROXYCITRIC ACID DERIVATIVES AND SKIN EXTERNAL PREPARATIONS CONTAINING THE SAME<br/>[FR] DERIVES D'ACIDE HYDROXYCITRIQUE ET PREPARATIONS EXTERNES POUR LA PEAU LES CONTENANT
  申请人：SHOWA DENKO KK

  公开号：WO2006033476A1

  公开（公告）日：2006-03-30

  Hydroxycitric acid derivatives and salts thereof are provided which are useful as active ingredients of skin external preparations and cosmetics. Also provided are processes for production of the hydroxycitric acid derivatives, and skin external preparations and cosmetics containing the hydroxycitric acid derivatives. Specific hydroxycitric acid derivatives or salts thereof are produced wherein at least one of the hydroxyl groups of hydroxycitric acid, or least one of the hydroxyl groups and at least one carboxyl group of hydroxycitric acid are modified to linkage moieties breakable by biological enzyme reaction. The hydroxycitric acid derivatives or salts thereof are added in skin external preparations and cosmetics.

  提供了羟基柠檬酸衍生物及其盐，可用作皮肤外用制剂和化妆品的活性成分。还提供了生产羟基柠檬酸衍生物的方法，以及含有羟基柠檬酸衍生物的皮肤外用制剂和化妆品。生产特定羟基柠檬酸衍生物或其盐，其中羟基柠檬酸的至少一个羟基或至少一个羟基和至少一个羧基被修饰为可被生物酶反应断裂的连接基团。将羟基柠檬酸衍生物或其盐添加到皮肤外用制剂和化妆品中。
• Slimming Skin External Preparation and Cosmetic Containing the Same
  申请人：Shibuya Akira

  公开号：US20070232698A1

  公开（公告）日：2007-10-04

  The invention provides a slimming skin external preparation and a cosmetic that contain a carnitine derivative having excellent skin affinity and percutaneous absorption properties and capable of enhancing the fat metabolism, and that can treat, reduce or prevent the obesity by functioning as a lipolytic agent to enhance the fat metabolism of general or local subcutaneous fat tissues. The slimming skin external preparation contains a particular carnitine derivative and preferably other slimming and skin-care ingredients.

  该发明提供了一种含有卡尼汀衍生物的减肥皮肤外用制剂和化妆品，该衍生物具有优异的皮肤亲和性和经皮吸收性能，并能够增强脂肪代谢，通过作为脂肪分解剂增强一般或局部皮下脂肪组织的脂肪代谢，从而能够治疗、减少或预防肥胖。该减肥皮肤外用制剂含有特定的卡尼汀衍生物，最好还包含其他减肥和护肤成分。
• Purification, molecular cloning, and expression of 2-hydroxyphytanoyl-CoA lyase, a peroxisomal thiamine pyrophosphate-dependent enzyme that catalyzes the carbon–carbon bond cleavage during α-oxidation of 3-methyl-branched fatty acids
  作者：Veerle Foulon、Vasily D. Antonenkov、Kathleen Croes、Etienne Waelkens、Guy P. Mannaerts、Paul P. Van Veldhoven、Minne Casteels

  DOI：10.1073/pnas.96.18.10039

  日期：1999.8.31

  In the third step of the α-oxidation of 3-methyl-branched fatty acids such as phytanic acid, a 2-hydroxy-3-methylacyl-CoA is cleaved into formyl-CoA and a 2-methyl-branched fatty aldehyde. The cleavage enzyme was purified from the matrix protein fraction of rat liver peroxisomes and identified as a protein made up of four identical subunits of 63 kDa. Its activity proved to depend on Mg ²⁺ and thiamine pyrophosphate, a hitherto unrecognized cofactor of α-oxidation. Formyl-CoA and 2-methylpentadecanal were identified as reaction products when the purified enzyme was incubated with 2-hydroxy-3-methylhexadecanoyl-CoA as the substrate. Hence the enzyme catalyzes a carbon–carbon cleavage, and we propose calling it 2-hydroxyphytanoyl-CoA lyase. Sequences derived from tryptic peptides of the purified rat protein were used as queries to recover human expressed sequence tags from the databases. The composite cDNA sequence of the human lyase contained an ORF of 1,734 bases that encodes a polypeptide with a calculated molecular mass of 63,732 Da. Recombinant human protein, expressed in mammalian cells, exhibited lyase activity. The lyase displayed homology to a putative Caenorhabditis elegans protein that resembles bacterial oxalyl-CoA decarboxylases. Similarly to the decarboxylases, a thiamine pyrophosphate-binding consensus domain was present in the C-terminal part of the lyase. Although no peroxisome targeting signal, neither 1 nor 2, was apparent, transfection experiments with constructs encoding green fluorescent protein fused to the full-length lyase or its C-terminal pentapeptide indicated that the C terminus of the lyase represents a peroxisome targeting signal 1 variant.

  在α-氧化的第三步中，对于类似植酸酸的3-甲基支链脂肪酸，2-羟基-3-甲基酰基辅酶A被裂解成甲酰辅酶A和2-甲基支链脂肪醛。该裂解酶从大鼠肝脏过氧化物酶体的基质蛋白分离纯化，并鉴定为由四个相同的63 kDa亚基组成的蛋白质。其活性被证明依赖于Mg2+和硫胺素焦磷酸，这是α-氧化中迄今未被认识的辅因子。当以2-羟基-3-甲基十六酰基辅酶A为底物孵育纯化的酶时，甲酰辅酶A和2-甲基十五烷醛被鉴定为反应产物。因此，这种酶催化碳-碳裂解，我们建议称其为2-羟基植酸酰基辅酶A裂解酶。从纯化的大鼠蛋白质的胰蛋白酶肽片段中得到的序列被用作查询，以从数据库中恢复人类表达序列标记。人类裂解酶的复合cDNA序列包含一个1,734个碱基的ORF，编码一个计算分子量为63,732 Da的多肽。在哺乳动物细胞中表达的重组人类蛋白表现出裂解活性。该裂解酶显示出与一种类似于细菌草酰辅酶A脱羧酶的假定的秀丽线虫蛋白质同源性。与脱羧酶类似，裂解酶的C端部分存在硫胺素焦磷酸结合共识域。尽管没有明显的过氧化物酶体靶向信号1或2，但编码全长裂解酶或其C端五肽与绿色荧光蛋白融合的构建体的转染实验表明，裂解酶的C端代表着过氧化物酶体靶向信号1变异体。