7-氨基-4-甲基-6-磺酸基香豆素-3-乙酸 | 244636-14-4

• 物质功能分类: 有机原料 - 氨基化合物 - 磺酸类氨基化合物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 中文名称: 7-氨基-4-甲基-6-磺酸基香豆素-3-乙酸
• 英文名称: 7-amino-4-methyl-6-sulfocoumarin-3-acetic acid
• 英文别名: Alexafluor 350；Alexa 350；2H-1-Benzopyran-3-acetic acid, 7-amino-4-methyl-2-oxo-6-sulfo-；2-(7-amino-4-methyl-2-oxo-6-sulfochromen-3-yl)acetic acid
• CAS: 244636-14-4
• 化学式: C₁₂H₁₁NO₇S
• 分子量: 313.288
• InChiKey: LRPDYFRNVROAIN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  152
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  O-(N-succinimidyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 7-氨基-4-甲基-6-磺酸基香豆素-3-乙酸 在 吡啶 作用下， 以90%的产率得到7-amino-4-methyl-6-sulfocoumarin-3-acetic acid succinimidyl ester
  参考文献：
  名称：

  7-Amino-4-methyl-6-sulfocoumarin-3-acetic acid: a novel blue fluorescent dye for protein labeling

  摘要：

  7-Amino-4-methyl-6-sulfocoumarin-3-acetic acid (AMCA-S, also called Alexa(TM) 350) 2 was synthesized as a new water-soluble blue fluorescent dye for protein labeling. Compared with its nonsulfonated counterpart (AMCA) 1 the new dye gave significantly higher fluorescence quantum yields on proteins. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00364-9
• 作为产物：
  描述：

  7-carboethoxyamido-4-methylcoumarin-3-acetic acid ethyl ester 在 硫酸 作用下， 以30%的产率得到7-氨基-4-甲基-6-磺酸基香豆素-3-乙酸
  参考文献：
  名称：

  7-Amino-4-methyl-6-sulfocoumarin-3-acetic acid: a novel blue fluorescent dye for protein labeling

  摘要：

  7-Amino-4-methyl-6-sulfocoumarin-3-acetic acid (AMCA-S, also called Alexa(TM) 350) 2 was synthesized as a new water-soluble blue fluorescent dye for protein labeling. Compared with its nonsulfonated counterpart (AMCA) 1 the new dye gave significantly higher fluorescence quantum yields on proteins. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00364-9

文献信息

• [EN] HEPARAN SULFATE GLYCOMIMETIC COMPOUNDS AND THEIR PHARMACEUTICAL AND COSMECEUTICAL USES<br/>[FR] COMPOSÉS GLYCOMIMÉTIQUES DE SULFATE D'HÉPARANE ET LEURS UTILISATIONS PHARMACEUTIQUES ET COSMÉTIQUES
  申请人：VICTORIA LINK LTD

  公开号：WO2018174725A1

  公开（公告）日：2018-09-27

  The invention relates to dendritic compounds, the use of these compounds as pharmaceuticals, pharmaceutical and cosmeceutical compositions containing the compounds, and methods of treating cancer, inflammation, diabetic nephropathy, neurodegenerative disorders, Niemann-Pick Type C disease, or dermatological conditions.

  该发明涉及树枝状化合物，这些化合物作为药物的使用，包含这些化合物的药物和美容药物组合物，以及治疗癌症、炎症、糖尿病肾病、神经退行性疾病、尼曼-皮克病C型或皮肤病学状况的方法。
• [EN] DENDRITIC CORE COMPOUNDS<br/>[FR] COMPOSÉS À CŒUR DENDRITIQUE
  申请人：CALLAGHAN INNOVATION RES LTD

  公开号：WO2014084743A1

  公开（公告）日：2014-06-05

  The invention relates to compounds that are useful for the preparation of dendrimer compounds, the use of these compounds for preparing dendrimers and processes for preparing the compounds.

  本发明涉及用于制备树枝状化合物有用的化合物，以及使用这些化合物来制备树枝状化合物的方法以及制备这些化合物的过程。
• ENTEROBACTIN CONJUGATES AND USES THEREOF
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：US20150105337A1

  公开（公告）日：2015-04-16

  The present invention provides novel enterobactin-cargo conjugates, such as compounds of Formula (I), and salts thereof, where X is the cargo and may be an antibiotic, a fluorophore, or biotin. The present invention also provides complexes, compositions, kits, and methods that involve the compounds of Formula (I) and are useful in delivering a cargo to a bacterium, treating a bacterial infection, cystic fibrosis, and/or inflammatory bowel disease in a subject, preventing a bacterial infection, cystic fibrosis, and/or inflammatory bowel disease in a subject, inhibiting the growth of or killing a bacterium, or determining the concentration of a bacterium in a biological sample. In certain embodiments, the bacterium is a Gram-negative bacterium.

  本发明提供了新型肠杆菌铁胞内载体共轭物，如式(I)化合物及其盐，其中X是载体，可以是抗生素、荧光素或生物素。本发明还提供了涉及式(I)化合物的络合物、组合物、试剂盒和方法，用于将载体传递给细菌，治疗受试者的细菌感染、囊性纤维化和/或炎症性肠病，预防受试者的细菌感染、囊性纤维化和/或炎症性肠病，抑制或杀死细菌的生长，或确定生物样品中细菌的浓度。在某些实施例中，细菌是革兰氏阴性细菌。
• LABELING REAGENTS AND METHODS OF THEIR USE
  申请人：Antoulinakis Evan

  公开号：US20090004753A1

  公开（公告）日：2009-01-01

  The present disclosure is directed to a reactive ester agent capable of conjugating a reporter molecule to a carrier molecule or solid support. The reactive ester agent has the general formula: wherein the variables are described throughout the application.

  本公开涉及一种反应性酯试剂，能够将报告分子与载体分子或固体支持物共轭。该反应性酯试剂具有以下通式：其中变量在本申请中进行了描述。
• Labeling Reagents and Methods of Their Use
  申请人：LIFE TECHNOLOGIES CORPORATION

  公开号：US20150355186A1

  公开（公告）日：2015-12-10

  The present disclosure is directed to a reactive ester agent capable of conjugating a reporter molecule to a carrier molecule or solid support. The reactive ester agent has the general formula: wherein the variables are described throughout the application.

  本公开涉及一种反应性酯试剂，能够将报告分子与载体分子或固体支持物结合。反应性酯试剂具有以下通式：其中变量在整个申请中描述。