8,11,14-二十碳三烯酸 | 7324-41-6

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 8,11,14-二十碳三烯酸
• 中文别名: 8,11,14-二十三碳烯酸；二高-Gamma-亚麻酸
• 英文名称: 8,11,14-Eicosatrienoic acid
• 英文别名: (8E,11E,14E)-icosa-8,11,14-trienoic acid
• CAS: 7324-41-6
• 化学式: C₂₀H₃₄O₂
• 分子量: 306.5
• InChiKey: HOBAELRKJCKHQD-YHTMAJSVSA-N

物化性质

• 沸点：
  438.0±24.0 °C(Predicted)
• 密度：
  0.917±0.06 g/cm3(Predicted)
• 保留指数：
  2345.9

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• BIOPASSIVATING MEMBRANE STABILIZATION BY MEANS OF NITROCARBOXYLIC ACID-CONTAINING PHOSPHOLIPIDS IN PREPARATIONS AND COATINGS
  申请人：Dietz Ulrich

  公开号：US20140099354A1

  公开（公告）日：2014-04-10

  The present invention relates to nitro-carboxylic acid (s)-containing phospholipids, to be used for coating of medical devices such as stents, catheter balloons, wound pads or surgical suture material and for bio-passivating compositions, such as rinses, waterproofing solutions, coating solutions, cryoprotection solutions, cold preservation media, lyoprotection solutions, contrast media solutions, preservation and reperfusion solutions containing these compounds as well as preparing solutions thereof and coating medical devices as well as their uses.

  本发明涉及一种含硝基羧酸（s）的磷脂，用于涂覆医疗器械，如支架、导管球囊、伤口垫或外科缝合材料，以及用于生物钝化组合物，如漱口液、防水溶液、涂层溶液、冷冻保护溶液、冷藏介质、冻干保护溶液、造影介质溶液、含有这些化合物的保存和再灌注溶液，以及制备这些溶液和涂覆医疗器械以及它们的用途。
• METHOD FOR PREPARING CARBOXYLIC ACIDS BY OXIDATIVE CLEAVAGE OF A VICINAL DIOL
  申请人：Lemaire Marc

  公开号：US20130131379A1

  公开（公告）日：2013-05-23

  The present invention relates to a method for preparing carboxylic acids, in particular mono- and dicarboxylic acids, by oxidative cleavage of a vicinal diol. According to the invention, said method consists of reacting a vicinal diol of formula I: where: p is an integer comprised between 1 and 6; R1 and R2 are, separately: an alkyl or hydroxyl group having 1 to 12 carbon atoms; a —(CH 2 ) n —C0 2 M group where n, which can be identical or different in R1 and R2, is an integer comprised between 1 and 11 and M is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms or an alkaline cation; or R1 and R2 jointly form an alkylene —(CH 2 )m- group where m is an integer comprised between 2 and 10, preferably between 2 and 6; with industrial-grade sodium hypochlorite (or bleach), in the absence of an organic solvent and without adding a catalyst, preferably at room temperature. The invention can be used for recycling natural vegetable oils.

  本发明涉及一种制备羧酸的方法，特别是通过对邻二醇进行氧化裂解制备单羧酸和二羧酸。 根据本发明，所述方法包括将式I的邻二醇进行反应： 其中： p是介于1和6之间的整数； R1和R2分别是： 具有1至12个碳原子的烷基或羟基基团； 一个—(CH 2 ) n —C0 2 M基团，其中n在R1和R2中可以相同也可以不同，是介于1和11之间的整数，M是氢原子或具有1至4个碳原子的烷基基团或碱性阳离子； 或者R1和R2共同形成一个亚烷基—(CH 2 )m-基团，其中m是介于2和10之间的整数，优选在2和6之间； 使用工业级次氯酸钠（或漂白剂），在无机溶剂的情况下且不添加催化剂的情况下，最好在室温下进行。该发明可用于回收天然植物油。
• PROCESS FOR PREPARING A CARBOXYLIC ACID FROM A DIOL OR FROM AN EPOXIDE BY OXIDATIVE CLEAVAGE
  申请人：SOCIETE INTEROLEAGINEUSE D'ASSISTANCE ET DE DEVELOPPEMENT (S.I.A.)

  公开号：US20150210623A1

  公开（公告）日：2015-07-30

  A process for preparing a carboxylic acid, by oxidative cleavage of at least one vicinal diol, or an epoxide, wherein the reaction is carried out in the presence of a catalyst and of an oxidizing agent and in the absence of solvent.

  通过氧化裂解至少一个邻二醇或环氧化物来制备羧酸的方法，其中反应在催化剂和氧化剂的存在下，在无溶剂的情况下进行。
• [EN] SMALL MOLECULE COMPOUNDS TO SUPPORT HEALTHY HUMAN AGING<br/>[FR] COMPOSÉS À PETITES MOLÉCULES POUR FAVORISER UN VIEILLISSEMENT HUMAIN SAIN
  申请人：CARDAX PHARMA INC

  公开号：WO2018183353A1

  公开（公告）日：2018-10-04

  Disclosed herein are methods of activating expression of the FOXO3 gene in a subject comprising administering to a subject small molecule compound (such as astaxanthin and/or one or more astaxanthin derivatives), or pharmaceutically acceptable salts thereof, in an amount sufficient to at least partially increase the amount of FoxO3 expressed in the subject.

  本文揭示了一种激活主体中FOXO3基因表达的方法，包括向主体施用小分子化合物（如虾青素和/或一个或多个虾青素衍生物）或其药用可接受盐，以足够数量至少部分增加主体中表达的FoxO3的方法。
• PROSTAGLANDIN E1 AND E2 ANALOGS FOR THE TREATMENT OF VARIOUS MEDICAL CONDITIONS
  申请人：Barta Nancy S.

  公开号：US20090124695A1

  公开（公告）日：2009-05-14

  A prostaglandin analog with selectivity to EP receptors and demonstrating EP agonist activity that may be used to expand hematopoietic stem cell populations or to treat or prevent influenza, bone fracture, bone disease, glaucoma, ocular hypertension, dysmenorrhoea, pre-term labor, immune disorders, osteoporosis, asthma, allergy, male sexual dysfunction, female sexual dysfunction, periodontal disease, gastric ulcer, renal disease, or other EP receptor-mediated conditions.

  一种选择性作用于EP受体的前列腺素类似物，表现出EP激动剂活性，可用于扩大造血干细胞群体或用于治疗或预防流感、骨折、骨病、青光眼、眼压升高、痛经、早产、免疫紊乱、骨质疏松症、哮喘、过敏、男性性功能障碍、女性性功能障碍、牙周病、胃溃疡、肾脏疾病或其他EP受体介导的疾病。