p-ethoxyacetophenone | 144818-72-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-ethoxyacetophenone
• 英文别名: 1-(4-ethoxyphenyl)propan-2-one；(4-ethoxy-phenyl)-acetone；(4-Aethoxy-phenyl)-aceton；1-(4-Ethoxyphenyl)acetone
• CAS: 144818-72-4
• 化学式: C₁₁H₁₄O₂
• 分子量: 178.231
• InChiKey: QFAYQKVAKVNBNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  p-ethoxyacetophenone 在 氢氧化钾 、 sodium hydroxide 、 溴 、 sodium acetate 作用下， 以 甲醇 、 乙醇 、 氯仿 、 丙酮 为溶剂， 反应 6.0h， 生成 1-(4-Ethoxy-phenyl)-2-(3-methoxy-phenylazo)-3-(4-nitro-phenyl)-propane-1,3-dione
  参考文献：
  名称：

  Has, Chandra; Saharia; Sharma, Journal of the Indian Chemical Society, 1996, vol. 73, # 11, p. 614 - 615

  摘要：

  DOI：
• 作为产物：
  描述：

  4-异丙烯基苯乙醚 在 碘 、 mercury(II) oxide 作用下， 生成 p-ethoxyacetophenone
  参考文献：
  名称：

  Behal; Tiffeneau, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1905, vol. 141, p. 597

  摘要：

  DOI：

文献信息

• MODULATORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE
  申请人：Durand-Reville Thomas

  公开号：US20110021513A1

  公开（公告）日：2011-01-27

  The present invention relates to modulators of IRAK kinase and provides compositions comprising such modulators, as well as methods therewith for treating conditions or diseases mediated by or associated with IRAK kinase.

  本发明涉及IRAK激酶的调节剂，并提供包含这些调节剂的组合物，以及利用这些调节剂治疗由IRAK激酶介导或相关的疾病或病症的方法。
• Novel Phenoxyalkylamine Derivatives. VII. Synthesis and Pharmacological Activities of 2-Alkoxy-5-((phenoxyalkylamino)alkyl)benzenesulfonamide Derivatives.
  作者：Shunichiro SAKURAI、Kazuya MITANI、Shigeki HASHIMOTO、Koji MORIKAWA、Shingo YASUDA、Eiichi KOSHINAKA、Hideo KATO、Yasuo ITO

  DOI：10.1248/cpb.40.1443

  日期：——

  To find a novel α-blocker with high α-blocking selectivity against dopamine D2-receptor affinity, we performed structural modification of the alkylene chains and the substituents on two benzene rings of 2-alkoxy-5-[(phenoxyalkylamino)alkyl]benzenesulfonamide derivatives. The modification of the alkylene chain between the amino moiety in the center of the molecule and the benzene ring (ring A) was found to be the most significant. 5-[2-[[2-(5-Fluoro-2-methoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide (II-4), which possesses 1-methylethyl as the alkylene chain, exhibited high α-blocking selectivity as well as potent α-blocking activity.

  为了找到一种对多巴胺D2受体亲和力具有高选择性的新的α-拮抗剂，我们对2-烷氧基-5-[(苯氧烷基氨基)烷基]苯磺酰胺衍生物的烷基链及两个苯环上的取代基进行了结构改造。发现位于分子中心的氨基部分与苯环（环A）之间的烷基链的改造是最显著的。具备1-甲基乙基作为烷基链的5-[2-[[2-(5-氟-2-甲氧基苯氧基)乙基]氨基]丙基]-2-甲氧基苯磺酰胺（II-4）表现出高α-拮抗选择性以及强效的α-拮抗活性。
• ACYL PSEUDOPEPTIDES WHICH CARRY A FUNCTIONALIZED AUXILIARY ARM
  申请人：BAUER Jacques

  公开号：US20130022628A1

  公开（公告）日：2013-01-24

  The present invention is directed in particular to dipeptide-like compounds derived from functionally substituted amino acids, having fatty acid chains bound thereto through amidification of the amine functional groups of said dipeptide-like compounds, one end portion of which bears an accessory functional side chain spacer, with the other end portion being an acid group either in neutral or charged state. Compounds of the present invention have immunomodulating properties like adjuvants. In addition, compounds of the invention can be grafted on a given antigen in order to modulate or tune the immune response or can be equally grafted on a pharmaceutical carrier to enhance the therapeutic effect or targeting thereof. Accordingly, compounds of the invention find use in human and veterinary medicine both as immunogens and diagnostic tools.

  本发明特别针对从功能取代的氨基酸中衍生出来的二肽类化合物，其通过酰胺化作用将脂肪酸链结合到所述二肽类化合物的胺基官能团上，其中一端部分具有辅助功能侧链间隔物，而另一端部分是一个酸基，可以是中性或带电状态。本发明的化合物具有类似佐剂的免疫调节特性。此外，本发明的化合物可以嫁接到给定的抗原上，以调节或调整免疫反应，也可以同样嫁接到药物载体上，以增强其治疗效果或靶向性。因此，本发明的化合物在人类和兽医医学中均可用作免疫原和诊断工具。
• Borrelidin-producing polyketide synthase and its uses
  申请人：Biotica Technology Limited

  公开号：EP1961747A2

  公开（公告）日：2008-08-27

  The present invention relates to the biosynthesis of polyketides and derives from the cloning of nucleic acids encoding a polyketide synthase and other associated proteins involved in the synthesis of the polyketide borrelidin. Materials and methods including enzyme systems, nucleic acids, vectors and cells are provided for the preparation of polyketides including borrelidin and analogues and derivatives thereof. Novel polyketide molecules are also provided.

  本发明与多酮类化合物的生物合成有关，源于对参与合成多酮类化合物硼瑞丁的多酮合成酶和其他相关蛋白的核酸编码的克隆。提供了制备包括硼瑞丁及其类似物和衍生物在内的多酮类化合物的材料和方法，包括酶系统、核酸、载体和细胞。还提供了新型多酮分子。
• Combination therapies with disulfiram
  申请人：Spring Discovery, Inc.

  公开号：US11033516B1

  公开（公告）日：2021-06-15

  Disclosed herein are compositions and methods for increasing lifespan, for preventing or treating a disease including an aging-related disorder, for reducing a symptom of aging, and/or boosting an immune system in a mammal. Also disclosed herein are compositions and methods for improving effectiveness of a vaccine in a mammal. The compositions comprise, at least, a therapeutically effective amount of disulfiram and one or more additional ingredients.

  本文公开了用于延长寿命、预防或治疗疾病（包括衰老相关疾病）、减轻衰老症状和/或增强哺乳动物免疫系统的组合物和方法。本文还公开了用于提高哺乳动物体内疫苗效力的组合物和方法。这些组合物至少包含治疗有效量的双硫仑和一种或多种附加成分。