D-天冬氨酸二叔丁酯盐酸盐 | 135904-71-1

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 天然氨基酸及其衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: D-天冬氨酸二叔丁酯盐酸盐
• 中文别名: D-天冬氨酸二叔丁酯；D-天冬氨酸 二叔丁酯
• 英文名称: di-tert-butyl 2-aminosuccinate hydrochloride
• 英文别名: di-tert-butyl D-aspartate hydrochloride salt；di-tert-butyl (2R)-2-aminosuccinate hydrochloride；(R)-Di-tert-butyl 2-aminosuccinate hydrochloride；ditert-butyl (2R)-2-aminobutanedioate;hydrochloride
• CAS: 135904-71-1
• 化学式: C₁₂H₂₃NO₄*ClH
• 分子量: 281.78
• InChiKey: GVLZIMQSYQDAHB-DDWIOCJRSA-N

物化性质

• 溶解度：
  溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。

计算性质

• 辛醇/水分配系数(LogP)：
  1.81
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  78.6
• 氢给体数：
  2
• 氢受体数：
  5

安全信息

• 海关编码：
  2922499990
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
Product Name: (R)-Di-tert-butyl 2-aminosuccinate hydrochloride
Synonyms: (R)-H-Asp(otBu)-otBu HCl

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

---

Section 3. Composition/information on ingredients.
Ingredient name: (R)-Di-tert-butyl 2-aminosuccinate hydrochloride
CAS number: 135904-71-1

---

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C12H23NO4.ClH
Molecular weight: 281.8

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  D-天冬氨酸二叔丁酯盐酸盐 在 palladium 10% on activated carbon 、 氢气 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 氰基亚甲基三正丁基膦 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 18.0h， 生成 di-tert-butyl (2R)-2-[[3-[2-[3-[[(1R)-3-tert-butoxy-1-tert-butoxycarbonyl-3-oxo-propyl]carbamoyl]-5-hydroxyphenoxy]ethoxy]-5-hydroxybenzoyl]amino]butanedioate
  参考文献：
  名称：

  BENZOATE COMPOUND

  摘要：

  本发明提供了一种苯甲酸酯化合物，具有肠肽酶抑制作用，并将该化合物用作治疗或预防肥胖、糖尿病等疾病的药物。由式（I）表示的化合物或其盐具有肠肽酶抑制作用，并可用作治疗或预防肥胖、糖尿病等疾病的药物。【在公式中，每个符号如规范中定义】。

  公开号：

  US20210403420A1

文献信息

• Identification of potent, nonabsorbable agonists of the calcium-sensing receptor for GI-specific administration
  作者：Steven M. Sparks、Paul K. Spearing、Caroline J. Diaz、David J. Cowan、Channa Jayawickreme、Grace Chen、Thomas J. Rimele、Claudia Generaux、Lindsey T. Harston、Shane G. Roller

  DOI：10.1016/j.bmcl.2017.09.008

  日期：2017.10

  of gastrointestinal nutrient sensing pathways provides a promising a new approach for the treatment of metabolic diseases including diabetes and obesity. The calcium-sensing receptor has been identified as a key receptor involved in mineral and amino acid nutrient sensing and thus is an attractive target for modulation in the intestine. Herein we describe the optimization of gastrointestinally restricted

  胃肠道营养物传感途径的调节为治疗包括糖尿病和肥胖症在内的代谢性疾病提供了一种有希望的新方法。钙敏感受体已被确定为涉及矿物质和氨基酸营养素敏感的关键受体，因此是肠内调节的诱人靶标。在本文中，我们描述了从包含3-氨基吡咯烷的模板开始的胃肠道限制钙敏感受体激动剂的优化，从而确定了GI限制激动剂19（GSK3004774）。
• PRODRUGS OF CYTOTOXIC ACTIVE AGENTS HAVING ENZYMATICALLY CLEAVABLE GROUPS
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20190077752A1

  公开（公告）日：2019-03-14

  The invention relates to novel prodrugs or conjugates of the general formula (Ia) in which cytotoxic drugs, for example kinesin spindle protein inhibitors, are masked with legumain-cleavable groups and hence release the drug, and to the use of these prodrugs or conjugates for treatment and/or prevention of diseases, and to the use of these prodrugs or conjugates for production of medicaments for treatment and/or prevention of diseases, especially of hyperproliferative and/or angiogenic disorders, for example cancers.

  该发明涉及通式(Ia)的新型前药或结合物，其中细胞毒性药物，例如动力蛋白抑制剂，被腿蛋白酶可切割基团掩蔽，从而释放药物，并且涉及使用这些前药或结合物用于治疗和/或预防疾病，以及使用这些前药或结合物用于生产用于治疗和/或预防疾病的药物，特别是治疗和/或预防高增殖和/或血管生成异常的疾病，例如癌症。
• DOUBLE-HEADED PROTEASE INHIBITOR
  申请人：UBE Industries, Ltd.

  公开号：EP3705471A1

  公开（公告）日：2020-09-09

  The present invention provides a compound that is highly safe and useful in the prevention, alleviation, and/or treatment of various diseases involving enteropeptidase inhibition and/or trypsin inhibition, a pharmaceutical composition containing the compound, a method for producing the compound, and the like. Specifically, the present invention provides a compound represented by the following general formula (I): [wherein: A1 and A2 each independently represent an inhibitor residue having at least one activity selected from an enteropeptidase inhibitory activity and a trypsin inhibitory activity; and Z represents a spacer that links A1 to A2] or a pharmaceutically acceptable salt thereof.

  本发明提供了一种在预防、缓解和/或治疗涉及肠肽酶抑制和/或胰蛋白酶抑制的各种疾病方面高度安全且有用的化合物、一种含有该化合物的药物组合物、一种生产该化合物的方法等。具体而言，本发明提供了由以下通式（I）代表的化合物： 其中A1和A2各自独立地代表具有至少一种选自肠肽酶抑制活性和胰蛋白酶抑制活性的抑制剂残基；Z代表连接A1和A2的间隔物]或其药学上可接受的盐。