[2-Bromo-4-(2,2,2-trifluoro-acetyl)-phenoxy]-acetic acid ethyl ester | 303143-07-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [2-Bromo-4-(2,2,2-trifluoro-acetyl)-phenoxy]-acetic acid ethyl ester
• 英文别名: Ethyl 2-[2-bromo-4-(2,2,2-trifluoroacetyl)phenoxy]acetate；ethyl 2-[2-bromo-4-(2,2,2-trifluoroacetyl)phenoxy]acetate
• CAS: 303143-07-9
• 化学式: C₁₂H₁₀BrF₃O₄
• 分子量: 355.108
• InChiKey: WASGCNPWCHMBNE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  [2-Bromo-4-(2,2,2-trifluoro-acetyl)-phenoxy]-acetic acid ethyl ester 在 吡啶 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 生成 (2-Bromo-4-{2,2,2-trifluoro-1-[(Z)-hydroxyimino]-ethyl}-phenoxy)-acetic acid ethyl ester
  参考文献：
  名称：

  Synthesis of novel phenoxy-linked diazirine glycero- and sphingolipid probes via trialkylaryltin intermediates

  摘要：

  Two photoaffinity lipid probes, phosphatidylcholine analog 1 and ceramide analog 2, were synthesized via trialkylaryltin intermediates 10b,b' using a Stille coupling strategy. The latter are stable for months at -20 degrees C. Iododestannylation afforded lipid probes I and 2. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01166-7
• 作为产物：
  描述：

  2,2,2-三氟-4-甲氧基乙酰苯 在 硫酸 、 氯 、 lithium chloride 、 mercury(II) oxide 作用下， 以 四氯化碳 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 [2-Bromo-4-(2,2,2-trifluoro-acetyl)-phenoxy]-acetic acid ethyl ester
  参考文献：
  名称：

  Synthesis of novel phenoxy-linked diazirine glycero- and sphingolipid probes via trialkylaryltin intermediates

  摘要：

  Two photoaffinity lipid probes, phosphatidylcholine analog 1 and ceramide analog 2, were synthesized via trialkylaryltin intermediates 10b,b' using a Stille coupling strategy. The latter are stable for months at -20 degrees C. Iododestannylation afforded lipid probes I and 2. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01166-7

文献信息

• Synthesis of novel phenoxy-linked diazirine glycero- and sphingolipid probes via trialkylaryltin intermediates
  作者：Guoqing Li、Robert Bittman

  DOI：10.1016/s0040-4039(00)01166-7

  日期：2000.8

  Two photoaffinity lipid probes, phosphatidylcholine analog 1 and ceramide analog 2, were synthesized via trialkylaryltin intermediates 10b,b' using a Stille coupling strategy. The latter are stable for months at -20 degrees C. Iododestannylation afforded lipid probes I and 2. (C) 2000 Elsevier Science Ltd. All rights reserved.