1H-Pyrrol-1-yloxy, 3-(((2,5-dioxo-1-pyrrolidinyl)oxy)carbonyl)-2,5-dihydro-2,2,5,5-tetramethyl- | 37558-29-5

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 1H-Pyrrol-1-yloxy, 3-(((2,5-dioxo-1-pyrrolidinyl)oxy)carbonyl)-2,5-dihydro-2,2,5,5-tetramethyl-
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 1-hydroxy-2,2,5,5-tetramethylpyrrole-3-carboxylate
• CAS: 37558-29-5
• 化学式: C₁₃H₁₈N₂O₅
• 分子量: 282.29
• InChiKey: VDSVTMQVXNIMMJ-UHFFFAOYSA-N

物化性质

• 熔点：
  175-178 °C
• 溶解度：
  甲醇

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  87.2
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• TSCA：
  Yes
• 安全说明：
  S24/25

文献信息

• [EN] NITROXIDES FOR USE AS CONTRAST AGENTS FOR OVERHAUSER MAGNETIC RESONANCE IMAGING (OMRI)<br/>[FR] NITROXYDES DESTINÉS À ÊTRE UTILISÉS COMME AGENTS DE CONTRASTE POUR L'IMAGERIE PAR RÉSONANCE MAGNÉTIQUE OVERHAUSER (OMRI)
  申请人：UNIV AIX MARSEILLE

  公开号：WO2017005879A1

  公开（公告）日：2017-01-12

  The present invention relates to an in vitro method for detecting and/ or quantifying the catalytic activity of an enzyme E, said method comprising the steps of: i) Contacting enzyme E with a compound of formula (la), or (lb): ii) Monitoring the conversion of compound (la) or (lb) into compound (IlIa) or (lllb) by Electron Paramagnetic Resonance (EPR) or Overhauser-enhanced Magnetic Resonance Imaging (OMRI), or by Proton Electron Double Resonance Imaging (PEDRI) thereby detecting or quantifying the activity of enzyme E wherein: Y is OC(=O), S(C=O), NR7; X is CH or N; R1, R2, R3, are each independently selected from C1-C6 alkyl optionally substituted by OH, NRe, COOH; R4, R5 are each independently selected from H, C1-C6 alkyl, C1-C6 alkoxy, NR8R9, SR10;R6 is H or C1-C6 alkyl; ==W is =W or is absent; W is O, S, or NR11; R7, R8, R9, R10, R11 are each independently selected from C1-C6 alkyl; n is 0, 1, 2 or 3, Z is a substrate residue of an enzyme E.

  本发明涉及一种体外方法，用于检测和/或定量酶E的催化活性，所述方法包括以下步骤：i) 将酶E与化合物（la）或（lb）的公式接触；ii) 通过电子顺磁共振（EPR）或Overhauser增强磁共振成像（OMRI），或通过质子电子双共振成像（PEDRI）监测化合物（la）或（lb）转化为化合物（IIIa）或（IIIb），从而检测或定量酶E的活性，其中：Y为OC(=O)，S(C=O)，NR7；X为CH或N；R1、R2、R3分别独立选择自C1-C6烷基，可选择性地被OH，NRe，COOH取代；R4、R5分别独立选择自H，C1-C6烷基，C1-C6烷氧基，NR8R9，SR10；R6为H或C1-C6烷基；==W为=W或不存在；W为O，S或NR11；R7、R8、R9、R10、R11分别独立选择自C1-C6烷基；n为0，1，2或3，Z为酶E的底物残基。
• Organo-Soluble Chitosan Salts and Chitosan-Derived Biomaterials Prepared Thereof
  申请人：Chu Chih-Chang

  公开号：US20110150999A1

  公开（公告）日：2011-06-23

  Organo-soluble chitosan salts, method for preparing organo-soluble salts, chitosan-derived materials prepared with organo-soluble chitosan salts, and methods for preparing chitosan-derived materials are disclosed.

  本发明涉及可溶于有机溶剂的壳聚糖盐，制备可溶于有机溶剂的盐的方法，用可溶于有机溶剂的壳聚糖盐制备的壳聚糖衍生材料，以及制备壳聚糖衍生材料的方法。
• Bioactive stents and methods for use thereof
  申请人：MediVas, LLC

  公开号：US20040170685A1

  公开（公告）日：2004-09-02

  The present invention is based on the discovery that stents can be coated with biodegradable, bioactive polymers that promote endogenous healing processes at a site of stent implantation. The polymers biodegrade over time, releasing agents which establish or re-establish the natural healing process in an artery. Preferably, the stent is implanted at the time an artery is damaged, such at the time of angioplasty to protect the damaged artery against deleterious blood-borne factors that initiate proliferation of smooth muscle cells.

  本发明的基础是发现支架上可以涂覆可生物降解的生物活性聚合物，这种聚合物可以促进支架植入部位的内源性愈合过程。 随着时间的推移，聚合物会发生生物降解，释放出能够建立或重建动脉自然愈合过程的物质。 支架最好在动脉受损时植入，例如在血管成形术时植入，以保护受损动脉免受血液中有害因子的影响，这些因子会导致平滑肌细胞增殖。
• Bioactive stents for type II diabetics and methods for use thereof
  申请人：Carpenter W. Kenneth

  公开号：US20050238689A1

  公开（公告）日：2005-10-27

  The present invention is based on the discovery that a vascular stent or other implantable medical device can be coated with a biodegradable biocompatible polymer to which is attached a bioligand that specifically captures progenitors of endothelial cells (PECs) from the circulating blood to promote endogenous formation of healthy endothelium in Type II diabetics. In one embodiment, the bioligand is a peptide that specifically binds to an integrin receptor on PECs. The invention also provides methods for using such vascular stents and other implantable devices to promote vascular healing in Type II diabetics, for example following mechanical intervention.

  本发明基于以下发现：在血管支架或其他植入式医疗设备上涂覆一种可生物降解的生物相容性聚合物，聚合物上附着一种生物配体，该生物配体可从循环血液中特异性捕获内皮细胞祖细胞（PECs），从而促进 II 型糖尿病患者健康内皮的内源性形成。在一个实施方案中，生物配体是一种能与 PECs 上的整合素受体特异性结合的多肽。本发明还提供了使用此类血管支架和其他植入装置促进 II 型糖尿病患者血管愈合的方法，例如在机械干预之后。
• BIOACTIVE STENTS AND METHODS FOR USE THEREOF
  申请人：Medivas, LLC

  公开号：EP1603485A2

  公开（公告）日：2005-12-14