L-缬氨酰-L-苏氨酸 | 72636-02-3

• 物质功能分类: 生物化工 - 生化试剂 - 氨基酸
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: L-缬氨酰-L-苏氨酸
• 英文名称: L-valyl-L-threonine
• 英文别名: Val-Thr；(2S,3R)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-hydroxybutanoic acid
• CAS: 72636-02-3
• 化学式: C₉H₁₈N₂O₄
• 分子量: 218.253
• InChiKey: GVRKWABULJAONN-VQVTYTSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  113
• 氢给体数：
  4
• 氢受体数：
  5

安全信息

• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为产物：
  描述：

  N-trifluoroacetyl-L-valine 在 N,N'-二环己基碳二亚胺 、 sodium hydroxide 作用下， 以 四氢呋喃 、 乙醇 、 水 为溶剂， 反应 30.0h， 生成 L-缬氨酰-L-苏氨酸
  参考文献：
  名称：

  Synthesis of dipeptides based on valine and threonine

  摘要：

  Val-Val, Val-Thr, and Thr-Val dipeptides were synthesized using trifluoroacetyl protecting group. The optical rotations of the products were similar to those of samples synthesized using Boc protection, which indicated the absence of racemization in the course of introduction and removal of trifluoroacetyl protection.

  DOI：

  10.1134/s1070428012100065

文献信息

• SUBSTRATE FOR ASSAYING BETA-GLUCAN AND/OR ENDOTOXIN AND ASSAY METHOD
  申请人：Kitagawa Takeshi

  公开号：US20100330700A1

  公开（公告）日：2010-12-30

  An object of the present invention is to provide a peptide derivative for determining β-glucan or endotoxin which allows high sensitivity measurement, and a method for determining β-glucan and/or endotoxin using the same. The present invention relates to (1) a peptide derivative represented by the following general formula [1]: X-A 1 -Gly-Arg-A 2 -E-D  [1], (2) a reagent for determining β-glucan and/or endotoxin comprising the above-described peptide derivative, (3) a method for determining β-glucan and/or endotoxin, characterized in that a sample containing β-glucan and/or endotoxin, an amebocyte lysate of a horseshoe crab and the above-described peptide derivative are reacted each other, then the resulting released compound represented by the following general formula [2]: H-A 2 -E-D  [2] is separated from unreacted substance and quantified, and the determination is made based on this value, and (4) a reagent kit for determining β-glucan and/or endotoxin, comprising an amebocyte lysate of a horseshoe crab and the above-described peptide derivative as constituents thereof.

  本发明的目的是提供一种用于测定β-葡聚糖或内毒素的肽衍生物，该肽衍生物允许高灵敏度测量，并提供使用该肽衍生物测定β-葡聚糖和/或内毒素的方法。本发明涉及(1)由以下通式[1]表示的肽衍生物：X-A1-Gly-Arg-A2-E-D[1]，(2)用上述肽衍生物的试剂用于测定β-葡聚糖和/或内毒素，(3)一种用于测定β-葡聚糖和/或内毒素的方法，其特征在于将含有β-葡聚糖和/或内毒素的样品、一种马蹄蟹的阿米巴溶解液和上述肽衍生物反应，然后分离出代表以下通式[2]的所释放的化合物：H-A2-E-D[2]，并对此值进行定量测定，然后进行测定，以及(4)用于测定β-葡聚糖和/或内毒素的试剂盒，其包括一种马蹄蟹的阿米巴溶解液和上述肽衍生物作为其组分。
• Method for obtaining peptide fragments by use of fluorinated organic acids
  申请人：SEIKO INSTRUMENTS INC.

  公开号：EP0885899A1

  公开（公告）日：1998-12-23

  This method obtains peptide fragments having ends of specific amino acids from a protein, which does not use an enzyme and thus is associated with minimum contamination. An organic acid represented by a general formula; CF3-(CF2) n-COOH, wherein n is an integer of 0 or larger, is allowed to act on a protein or peptide.

  这种方法可以从蛋白质中获得具有特定氨基酸末端的肽片段，无需使用酶，因此污染最小。通式为 CF3-(CF2) n-COOH（其中 n 为 0 或更大的整数）的有机酸可作用于蛋白质或肽。
• SUBSTRATE FOR ASSAYING -GLUCAN AND/OR ENDOTOXIN AND ASSAY METHOD
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：EP2248821B1

  公开（公告）日：2015-01-28
• TAU PROTEASE COMPOSITIONS AND METHODS OF USE
  申请人：Oligomerix, Inc.

  公开号：US20140286954A1

  公开（公告）日：2014-09-25

  Disclosed are mammalian tau proteases, as well as proteolytically-active fragments, variants, and mutants thereof. Also disclosed are polynucleotides and recombinant expression vectors that encode these polypeptides, as well as methods for producing such proteins in selected recombinant host cells, and for using the compositions in a variety of diagnostic and analytical assays.
• US8546072B2
  申请人：——

  公开号：US8546072B2

  公开（公告）日：2013-10-01

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