1,2-bis-oleoyloxy-propane | 105-62-4

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1,2-bis-oleoyloxy-propane
• 英文别名: 1,2-Bis-oleoyloxy-propan；1-methyl-1,2-ethanediyl dioleate；propylene glycol dioleate；2-[(Z)-octadec-9-enoyl]oxypropyl (Z)-octadec-9-enoate
• CAS: 105-62-4
• 化学式: C₃₉H₇₂O₄
• 分子量: 604.998
• InChiKey: UMHYVXGZRGOICM-AUYXYSRISA-N

物化性质

• 沸点：
  641.2±48.0 °C(Predicted)
• 密度：
  0.907±0.06 g/cm3(Predicted)
• LogP：
  16.260 (est)
• 物理描述：
  Liquid

计算性质

• 辛醇/水分配系数(LogP)：
  15.4
• 重原子数：
  43
• 可旋转键数：
  35
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2916190090
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P330,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H302,H315,H319,H335

制备方法与用途

制备方法
广泛用于膏霜、乳液等，此外，在非水体系中还可作为无机颜料的分散助剂及粉底霜成分等。

用途简介

用途
广泛用于膏霜、乳液等，此外，在非水体系中还可作为无机颜料的分散助剂及粉底霜成分等。

反应信息

• 作为产物：
  描述：

  油酰氯 、 1,2-丙二醇 生成 1,2-bis-oleoyloxy-propane
  参考文献：
  名称：

  Abderhalden; Eichwald, Chemische Berichte, 1914, vol. 47, p. 1859

  摘要：

  DOI：

文献信息

• COMPOUNDS FOR TARGETING DRUG DELIVERY AND ENHANCING siRNA ACTIVITY
  申请人：Niitsu Yoshiro

  公开号：US20130017249A1

  公开（公告）日：2013-01-17

  Here described are compounds consisting of the structure (targeting molecule) m -linker-(targeting molecule) n , wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.

  这里描述的是由结构（靶向分子）m-连接物（靶向分子）n组成的化合物，其中靶向分子是一种视黄醇或脂溶性维生素，在靶细胞上具有特定的受体；其中m和n独立地为0、1、2或3；连接物包括聚乙二醇（PEG）或类似PEG的分子，以及包括这些化合物的组合物和药物制剂，用于治疗剂的靶向和传递；以及使用这些组合物和药物制剂的方法。
• Compounds for targeting drug delivery and enhancing siRNA activity
  申请人：Niitsu Yoshiro

  公开号：US09393315B2

  公开（公告）日：2016-07-19

  Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.

  这里描述的是由结构（靶向分子）m-连接体-(靶向分子)n组成的化合物，其中靶向分子是一种视黄醇或脂溶性维生素，在靶细胞上具有特定的受体; 其中m和n独立地为0、1、2或3; 连接体包括聚乙二醇（PEG）或类似PEG的分子，以及包括这些化合物的组合物和制药配方，这些化合物对于治疗剂的靶向和传递是有用的; 以及使用这些组合物和制药配方的方法。
• Novel lipophilic compounds having affinity with nucleic acids and therapeutical uses thereof
  申请人：——

  公开号：US20010056074A1

  公开（公告）日：2001-12-27

  The invention consists of a compound of the general formula (I) below: 1 Wherein A, R1, R2, R3, R4 and X are as disclosed in the specification. The invention also relates to the therapeutical uses of this compound, particularly for gene therapy.

  本发明包括以下通式(I)的化合物： 1 其中 A、R1、R2、R3、R4 和 X 如说明书中所公开。 本发明还涉及该化合物的治疗用途，特别是用于基因治疗。
• Fluorescent cell markers
  申请人：Korchagina Elena

  公开号：US20100203637A1

  公开（公告）日：2010-08-12

  The preparation and use of fluorescent cell markers of the structure F—S 1 -S 2 -L is described where F is a fluorophore, S 1 -S 2 is a spacer linking F to L, and L is a diacyl lipid.
• DOUBLE-STRANDED LIPID-MODIFIED RNA HAVING HIGH RNA INTERFERENCE EFFECT
  申请人：Kubo Takanori

  公开号：US20110034545A1

  公开（公告）日：2011-02-10

  An object of the present invention is to provide a novel double-stranded RNA that has high resistance to nuclease and cellular uptake efficiency and that can produce an excellent RNA interference effect. The present invention provides a double-stranded lipid-modified RNA comprising a sense strand having a nucleotide sequence complementary to a target sequence in a target gene, and an antisense strand having a nucleotide sequence complementary to the sense strand, the double-stranded RNA being capable of suppressing the expression of the target gene, and the sense strand having a double-stranded lipid bound directly or via a linker to at least one of the first to sixth nucleotides from the 5′ end.