D-myo-inositol 3,4-bisphosphate | 69256-53-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-myo-inositol 3,4-bisphosphate
• 英文别名: 1D-myo-Inositol 3,4-bisphosphate；[(1S,2R,3S,4S,5S,6S)-2,3,4,5-tetrahydroxy-6-phosphonooxycyclohexyl] dihydrogen phosphate
• CAS: 69256-53-7
• 化学式: C₆H₁₄O₁₂P₂
• 分子量: 340.117
• InChiKey: MCKAJXMRULSUKI-CNWJWELYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  214
• 氢给体数：
  8
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  (±)-2,3:5,6-di-O-isopropylidene-1,4-di-O-benzyl-myo-inositol 在 palladium on activated charcoal 吡啶 、 四氮唑 、 4-二甲氨基吡啶 、 lithium hydroxide 、 palladium on activated charcoal 、 氢气 、 碳酸氢钠 、 溶剂黄146 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 90.0 ℃ 、344.75 kPa 条件下， 反应 137.0h， 生成 D-myo-inositol 3,4-bisphosphate
  参考文献：
  名称：

  Divergent Synthesis of All Possible Optically Active Regioisomers ofMyo‐Inositol Mono‐ and Bisphosphates

  摘要：

  All possible optically active regioisomers of myo- inositol mono- and bisphosphates were synthesized using inositol derivatives suitably protected with various protecting groups (IR(n)s) as key intermediates. A series of procedures including Novozym 435 catalyzed enzymatic resolution of (3aR, 4S, 7S, 7aR)-rel-3a, 4,7,7a-tetrahydro- 2,2-dimethyl- 1,3- benzodioxole-4,7- diol diacetate, several protection and deprotection reactions, and acyl migration afforded two enantiomeric pairs of IR5 and six enantiomeric pairs of IR4. Phosphorylation of these key intermediates by the phosphitylation and oxidation procedure gave the target products after removal of the protecting groups.[GRAPHICS]

  DOI：

  10.1080/07328300701540225

文献信息

• Photo-labile protecting agents and method
  申请人：MEDICAL RESEARCH COUNCIL

  公开号：EP0233403A1

  公开（公告）日：1987-08-26

  The invention provides diazo compounds having the formula XYCNN and their parent hydrazones, where X is an ortho-nitro aromatic group such as o-nitrophenyl and Y is a hydrocarbon group such as methyl. The hydrazones may be prepared by reacting the corresponding ketone with hydrazine and the diazo compounds by hydrazone oxidation. The diazo compound may be reacted with an organic compound having a reactive hydrogen atom such as phosphate, thiophosphate, phosphonate, carboxyl and phenol, to form a caged compound from which the original organic compound can be released by photolysis, eg in situ in a biological system. Preferred organic compounds are ATP and other nucleotides.

  本发明提供了具有式 XYCNN 的重氮化合物及其母体肼酮，其中 X 为邻硝基苯基等正硝基芳香基团，Y 为甲基等烃基团。肼酮可通过相应的酮与肼反应制备，重氮化合物可通过腙氧化反应制备。重氮化合物可与具有活性氢原子（如磷酸盐、硫代磷酸盐、膦酸盐、羧基和苯酚）的有机化合物反应，形成笼状化合物，原有机化合物可通过光解（如在生物系统中的原位光解）从中释放出来。首选的有机化合物是 ATP 和其他核苷酸。
• Insulin activity messengers, their precursors and uses thereof
  申请人：ROCKEFELLER UNIVERSITY

  公开号：EP0245956A2

  公开（公告）日：1987-11-19

  An insulin activity messenger material and its precursor material are disclosed which have been isolated from hapatic plasma membrane cells that have been incubated with an enzyme known as a phosphatidylinositol-specific phospholipase C. The messenger material comprises a carbohydrate-based compound that exhibits the ability to modulate the activity of the insulin-sensitive enzymes pyruvate dehydrogenase, adenylate cyclase, acetyl CoA carboxylase, and low Km CAMP phosphodiesterase, and thereby effectuate the activity of insulin on the cellular level. The precursor material comprises an inositol containing glycolipid capable of phosphodiesteratic cleavage by a phosphatidylinositol-specific phospholipase C. The enzyme phosphatidylinositol-glycan specific phospholipase C has also been purified and found to participate in many of the activities identified with respect to the messenger and its precursor. Numerous diagnostic and therapeutic utilities are proposed, and testing procedures, materials in kit form and pharmaceutical compositions are likewise set forth.

  本发明公开了一种胰岛素活性信使物质及其前体物质，它们是从与一种称为磷脂酰肌醇特异性磷脂酶 C 的酶培养过的单肝浆膜细胞中分离出来的。这种信使材料包括一种基于碳水化合物的化合物，它能够调节对胰岛素敏感的丙酮酸脱氢酶、腺苷酸环化酶、乙酰 CoA 羧化酶和低 Km CAMP 磷酸二酯酶的活性，从而在细胞水平上影响胰岛素的活性。前体物质包括一种含肌醇的糖脂，能够被磷脂酰肌醇特异性磷脂酶 C 磷酸二酯化裂解。磷脂酰肌醇-糖特异性磷脂酶 C 也已被纯化，并发现它参与了许多与信使及其前体有关的活动。此外，还提出了许多诊断和治疗方法，以及测试程序、试剂盒形式的材料和药物组合物。
• Compounds for the treatment of hypercalcemia and hypocalcemia
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：EP1586641A2

  公开（公告）日：2005-10-19

  An antagonist or agonist compound for use in the treatment of hypercalcemia or hypocalcemia. The compound is identifiable as being a compound capable of competing with a parathyroid hormone or parathyroid hormone-related protein for binding to a parathyroid hormone receptor. Identification is carried out by contacting a polypeptide with a parathyroid hormone or parathyroid hormone-related protein in the presence or absence of a candidate compound. The polypeptide comprises at least six amino acids and less than the complete amino acid sequence of a parathyroid hormone receptor having an amino acid sequence with at least 30% identity to the amino acid sequence shown in SEQ. ID NO. 3.

  一种用于治疗高钙血症或低钙血症的拮抗剂或激动剂化合物。该化合物可被鉴定为能与甲状旁腺激素或甲状旁腺激素相关蛋白竞争结合到甲状旁腺激素受体上的化合物。鉴定方法是在有或没有候选化合物的情况下，将多肽与甲状旁腺激素或甲状旁腺激素相关蛋白接触。多肽至少包含六个氨基酸，且少于甲状旁腺激素受体的完整氨基酸序列，其氨基酸序列与 SEQ.ID NO.
• BONE REGENERATION MATERIAL KIT, PASTE-LIKE BONE REGENERATION MATERIAL, BONE REGENERATION MATERIAL, AND BONE BONDING MATERIAL
  申请人：Gunze Limited

  公开号：EP3031478A1

  公开（公告）日：2016-06-15

  The present invention aims to provide a bone regeneration material kit, a paste-like bone regeneration material, a bone regeneration material, and a bone bonding material, which contain particles including a bioabsorbable polymer; and can fill a bone defect or damage and secure the mechanical strength of the bone in the short term and can promote regeneration of the patient's own bone in the long term. In addition, they can exhibit anti-washout properties after filling even when they are in contact with water such as blood or biological fluids. The present invention relates to a bone regeneration material kit comprising: a particle comprising a calcium salt and having an inositol phosphate or salt thereof adsorbed on the surface; a particle comprising a bioabsorbable polymer; and an aqueous medium.

  本发明旨在提供一种骨再生材料试剂盒、一种膏状骨再生材料、一种骨再生材料和一种骨粘合材料，它们含有包括生物可吸收聚合物在内的颗粒；短期内可填充骨缺损或损伤并确保骨的机械强度，长期内可促进患者自身骨的再生。此外，它们在填充后即使与血液或生物液体等水接触，也能表现出抗冲刷特性。本发明涉及一种骨再生材料试剂盒，包括：由钙盐组成且表面吸附有肌醇磷酸酯或其盐的颗粒；由生物可吸收聚合物组成的颗粒；以及水介质。
• ORGANICALLY MODIFIED MINERAL MICRO-PARTICLES, METHODS OF PREPARING THE SAME AND USES THEREOF
  申请人：Croda Denmark A/S

  公开号：EP3556728A1

  公开（公告）日：2019-10-23

  The present invention is situated in the field of mineral micro-particles selected from the list consisting of aluminum hydroxide, aluminum phosphate, amorphous aluminium hydroxyphosphate and calcium phosphate micro-particles. More particularly, the invention provides organically-derivatized mineral micro-particles, uses thereof, and methods of preparing the same.

  本发明涉及从氢氧化铝、磷酸铝、无定形羟基磷酸铝和磷酸钙微粒清单中选出的矿物微粒领域。更具体地说，本发明提供了有机衍生矿物微粒、其用途以及制备方法。