(1R,2S,4R,6R,7S)-4-Chloromethyl-5-isopropyl-1,10,10-trimethyl-3-oxa-5-aza-4-phospha-tricyclo[5.2.1.0^2,6]decane 4-oxide | 258282-36-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1R,2S,4R,6R,7S)-4-Chloromethyl-5-isopropyl-1,10,10-trimethyl-3-oxa-5-aza-4-phospha-tricyclo[5.2.1.0^2,6]decane 4-oxide
• 英文别名: (1R,2S,4S,6R,7S)-4-(chloromethyl)-1,10,10-trimethyl-5-propan-2-yl-3-oxa-5-aza-4lambda5-phosphatricyclo[5.2.1.02,6]decane 4-oxide；(1R,2S,4S,6R,7S)-4-(chloromethyl)-1,10,10-trimethyl-5-propan-2-yl-3-oxa-5-aza-4λ5-phosphatricyclo[5.2.1.02,6]decane 4-oxide
• CAS: 258282-36-9
• 化学式: C₁₄H₂₅ClNO₂P
• 分子量: 305.785
• InChiKey: FKWNXMHMOAUVNQ-ABZJQIFXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  溴甲苯 、 (1R,2S,4R,6R,7S)-4-Chloromethyl-5-isopropyl-1,10,10-trimethyl-3-oxa-5-aza-4-phospha-tricyclo[5.2.1.0^2,6]decane 4-oxide 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 7.0h， 生成 (1R,2S,4R,6R,7S)-4-((R)-1-Chloro-2-phenyl-ethyl)-5-isopropyl-1,10,10-trimethyl-3-oxa-5-aza-4-phospha-tricyclo[5.2.1.0^2,6]decane 4-oxide 、 (1R,2S,4R,6R,7S)-4-((S)-1-Chloro-2-phenyl-ethyl)-5-isopropyl-1,10,10-trimethyl-3-oxa-5-aza-4-phospha-tricyclo[5.2.1.0^2,6]decane 4-oxide
  参考文献：
  名称：

  Camphor-based oxazaphospholanes as chiral templates for the enantioselective synthesis of α-chlorophosphonic acids

  摘要：

  Constrained camphor-derived oxazaphospholanes have provided an efficient entry for the preparation of enantiomerically enriched alpha-chlorophosphonic acids. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00455-3
• 作为产物：
  描述：

  (1R,2S,3R,4S)-3-Isopropylamino-1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-ol 、 氯甲基膦酸二氯化物 在 三乙胺 作用下， 以 甲苯 为溶剂， 反应 6.0h， 生成 (1R,2S,4S,6R,7S)-4-Chloromethyl-5-isopropyl-1,10,10-trimethyl-3-oxa-5-aza-4-phospha-tricyclo[5.2.1.0^2,6]decane 4-oxide 、 (1R,2S,4R,6R,7S)-4-Chloromethyl-5-isopropyl-1,10,10-trimethyl-3-oxa-5-aza-4-phospha-tricyclo[5.2.1.0^2,6]decane 4-oxide
  参考文献：
  名称：

  Camphor-based oxazaphospholanes as chiral templates for the enantioselective synthesis of α-chlorophosphonic acids

  摘要：

  Constrained camphor-derived oxazaphospholanes have provided an efficient entry for the preparation of enantiomerically enriched alpha-chlorophosphonic acids. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(99)00455-3

文献信息

• Camphor-based oxazaphospholanes as chiral templates for the enantioselective synthesis of α-chlorophosphonic acids
  作者：Giovanni Battista Giovenzana、Roberto Pagliarin、Giovanni Palmisano、Tullio Pilati、Massimo Sisti

  DOI：10.1016/s0957-4166(99)00455-3

  日期：1999.11

  Constrained camphor-derived oxazaphospholanes have provided an efficient entry for the preparation of enantiomerically enriched alpha-chlorophosphonic acids. (C) 1999 Elsevier Science Ltd. All rights reserved.