N-(1-氧代十二烷基)-L-谷氨酸(9CI) | 3397-65-7

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 谷氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-(1-氧代十二烷基)-L-谷氨酸(9CI)
• 中文别名: N-月桂酰-L-谷氨酸；月桂酰基谷氨酸；(S)-2-十二酰胺戊二酸
• 英文名称: N-dodecanoyl-L-glutamic acid
• 英文别名: N-lauroyl-L-glutamic acid；lauroylglutamic acid；N-lauroyl glutamic acid；N-Lauroyl-L-glutaminsaeure；(2S)-2-(dodecanoylamino)pentanedioic acid
• CAS: 3397-65-7
• 化学式: C₁₇H₃₁NO₅
• 分子量: 329.437
• InChiKey: AVBJHQDHVYGQLS-AWEZNQCLSA-N

物化性质

• 熔点：
  95-96 °C
• 沸点：
  543.6±40.0 °C(Predicted)
• 密度：
  1.081±0.06 g/cm3(Predicted)
• 溶解度：
  可溶于水基（轻微），氯仿（轻微）
• LogP：
  2.964 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  23
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2924199090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335
• 储存条件：
  存放于室温环境下，保持干燥并密封保存。

反应信息

• 作为反应物：
  描述：

  N-(1-氧代十二烷基)-L-谷氨酸(9CI) 在 正己烷 作用下， 以 乙酸酐 为溶剂， 反应 5.0h， 以to obtain 72.4 g of Nα-lauroyl-L-glutamic anhydride的产率得到Lauroylglutamic acid anhydride
  参考文献：
  名称：

  POLYSACCHARIDES AND EMULSIFIED PRODUCTS CONTAINING THE SAME

  摘要：

  提供一种具有优异的水分散性能的新物质，能够形成快速展开到皮肤上的乳液，不会因盐而发生聚集或分离，并且在低温下稳定性优异。通过一种特定的多糖来解决上述问题并得到了该发明。

  公开号：

  US20130231402A1
• 作为产物：
  描述：

  十二烷酰基-L-谷氨酸二乙酯 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 N-(1-氧代十二烷基)-L-谷氨酸(9CI)
  参考文献：
  名称：

  两亲性L-谷氨酸与联吡啶共组装中手性扭曲和超分子手性的调节

  摘要：

  一系列两亲L‐glutamic acid derivatives with various saturated alkyl chains has been designed and their co‐assembly with 4,4′‐bipyridine in aqueous media has been investigated. While the individual amphiphiles formed hydrogels with water and self‐assembled into fine fiber networks, the addition of 4,4′‐bipyridine caused significant changes in the co‐assembled nanostructures such that twisted chiral ribbons

  DOI：

  10.1002/chem.201002595

文献信息

• Isolation and total synthesis of gymnastatin N, a POLO-like kinase 1 active constituent from the fungus Arachniotus punctatus
  作者：Chee Wee Phoon、Brinda Somanadhan、Sabrina Cher Hui Heng、Anna Ngo、Siew Bee Ng、Mark S. Butler、Antony D. Buss、Mui Mui Sim

  DOI：10.1016/j.tet.2004.09.046

  日期：2004.12

  as a minor component. Gymnastatin N (1) was found to be a 52:48 mixture of (1S,6′R) and (1R,6′R) diastereomers, by synthesis of the four possible diastereomers and comparison of the optical rotation and chiral HPLC profile of each diastereoisomer with the natural product. Analogues of 1 were synthesized and evaluated against the Plk1 assay and these SAR studies suggested that the diene and free carboxylic

  针对POLO样激酶1（Plk1）（一种抗癌靶标）的高通量筛选，鉴定了一种来自点状真菌Arachniotus punctatus的活性提取物。生物测定指导的分馏导致分离出新的天然产物gymaststatin N（1）和已知的化合物阿诺洛糖醇A（2），IC 50值分别为13和118μM 。分离出金格他汀N，3的12'-羟基类似物作为次要成分。Gymnastatin N（1）被认为是（1的52:48混合物小号，6' - [R ）和（1 - [R，6' - [R）非对映异构体，可以合成四种可能的非对映异构体，并比较每种非对映异构体与天然产物的旋光度和手性HPLC谱。合成了类似物1并针对Plk1分析进行了评估，这些SAR研究表明，二烯和游离羧酸部分可能是其生物活性的原因。
• [EN] POLYEHYLENE GLYCOL-PEPTIDE COPPER COMPLEXES AND COMPOSITIONS AND METHODS RELATED THERETO<br/>[FR] COMPLEXES DE POLYETHYLENE GLYCOL-PEPTIDE-CUIVRE ET COMPOSITIONS ET METHODES Y ETANT ASSOCIEES
  申请人：PROCYTE CORP

  公开号：WO2006023465A1

  公开（公告）日：2006-03-02

  This invention relates to compositions comprising polyethylene glycol molecules coupled to peptide copper complexes, and, additionally, to such compositions formulated for use as pharmaceutical and cosmetic products, as well as to medical devices that comprise such compositions.

  这项发明涉及包含聚乙二醇分子偶联到肽铜络合物的组合物，此外，还涉及配制用作药用和化妆品产品的这种组合物，以及包含这种组合物的医疗器械。
• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• Surface-Treating Agents, Surface-Treated Powders, And Cosmetics Comprising The Same
  申请人：Nishihama Shuji

  公开号：US20080081029A1

  公开（公告）日：2008-04-03

  To provide surface-treating agents that can provide excellent hydrophobicity to powder and can improve its rinsability, to provide surface-treated powders that are treated with the surface-treating agent, and to provide cosmetics that comprise the surface-treated powder. A surface-treating agent consisting of a polymer which comprises a monomer (A) represented by the general formula (1) described below as a constituent monomer. (wherein R 1 represents a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R 2 represents an alkylene group having 4 to 22 carbon atoms, X 1 represents an —NH— group or an oxygen atom, and M 1 represents a hydrogen atom or a monovalent inorganic or organic cation.)

  提供能够为粉末提供出色疏水性并改善其可冲洗性的表面处理剂，提供经表面处理剂处理的粉末，以及提供包含经表面处理的粉末的化妆品。一种表面处理剂，由包含下述通用式（1）所描述的单体（A）作为组分单体的聚合物组成。 （其中R1代表氢原子或具有1至3个碳原子的烷基基团，R2代表具有4至22个碳原子的烷基基团，X1代表—NH—基团或氧原子，M1代表氢原子或一价无机或有机阳离子。）
• OIL-IN-WATER EMULSION COSMETIC COMPOSITION
  申请人：Dow Toray Co., Ltd.

  公开号：US20210330559A1

  公开（公告）日：2021-10-28

  An oil-in-water emulsion cosmetic composition is provided. The oil-in-water emulsion cosmetic composition comprises a carboxylic acid modified silicone (A) that has a specific chemical structure and is liquid at room temperature, an oil agent (B), and water (C). The oil-in-water emulsion cosmetic composition can provide a cosmetic film with high stability and excellent water resistance.

  提供了一种油包水乳化化妆品组合物。该油包水乳化化妆品组合物包括一种在室温下为液体的具有特定化学结构的羧酸改性硅氧烷（A）、一种油剂（B）和水（C）。该油包水乳化化妆品组合物可以提供具有高稳定性和优异耐水性的化妆膜。