(S,3E)-4-[(S)-1,2,3,4,5,6,7,8-octahydro-2,2-dimethylnaphthalen-1-yl]but-3-en-2-ol O-tert-butyldimethylsilyl ether | 1187954-04-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (S,3E)-4-[(S)-1,2,3,4,5,6,7,8-octahydro-2,2-dimethylnaphthalen-1-yl]but-3-en-2-ol O-tert-butyldimethylsilyl ether
• 英文别名: tert-butyl-[(E,2S)-4-[(1S)-2,2-dimethyl-3,4,5,6,7,8-hexahydro-1H-naphthalen-1-yl]but-3-en-2-yl]oxy-dimethylsilane
• CAS: 1187954-04-6
• 化学式: C₂₂H₄₀OSi
• 分子量: 348.644
• InChiKey: FFTBRMCRUMTRLF-JJMHFJPWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.26
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (S,3E)-4-[(S)-1,2,3,4,5,6,7,8-octahydro-2,2-dimethylnaphthalen-1-yl]but-3-en-2-ol O-tert-butyldimethylsilyl ether 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Enantioselective Synthesis and Olfactory Evaluation of Bicyclic α- and γ-Ionone Derivatives: The 3D Arrangement of Key Molecular Features Relevant to the Violet Odor of Ionones

  摘要：

  Violet smelling ionones 1-3, occurring in the headspace of different flowers, are well-known perfumery raw materials. With the goal to recognize the still ill-defined spatial arrangement of structural features relevant to the binding of ionones to olfactory G-protein coupled receptors, through B3LYP/6-31G(d) modeling studies we identified bicyclic compounds 7-9 as conformationally constrained 13-alkyl-substituted analogues of monocyclic alpha- and gamma-ionones. They were thus synthesized to evaluate the olfactory properties. The enantioselective syntheses of 7-9 entailed two common key steps: (i) a Diels-Alder reaction to construct the octalinic core and (ii) a Julia-Lythgoe olefination to install the alpha,beta-enone side chain. The odor thresholds of synthetic 7 and 9 were significantly lower than the corresponding parent ionones, and 9 showed the lowest threshold value among violet-smelling odorants examined so far. Modeling studies Suggested a nearly identical spatial orientation of key hydrophobic and polar moieties of compounds 1, 3, and 4-9. Presumably, interaction of these moieties with ionone olfactory receptors (ORs) triggers a similar receptor code that is ultimately interpreted by the human brain as a pleasant woody-violet smell. These results open the way to studies aimed at identifying and modeling complementary binding sites on alpha-helical domains of ionone receptor proteins.

  DOI：

  10.1021/jo9014936
• 作为产物：
  描述：

  (S)-1,2,3,4,5,6,7,8-octahydro-2,2-dimethyl-1-[(phenylsulfonyl)methyl]naphthalene 、 (S)-2-(叔丁基-二甲基-锡氧基)-丙醛 在 正丁基锂 、 disodium hydrogenphosphate 、 sodium amalgam 作用下， 以 四氢呋喃 、 正己烷 、 甲醇 为溶剂， 反应 3.0h， 以70%的产率得到(S,3E)-4-[(S)-1,2,3,4,5,6,7,8-octahydro-2,2-dimethylnaphthalen-1-yl]but-3-en-2-ol O-tert-butyldimethylsilyl ether
  参考文献：
  名称：

  Enantioselective Synthesis and Olfactory Evaluation of Bicyclic α- and γ-Ionone Derivatives: The 3D Arrangement of Key Molecular Features Relevant to the Violet Odor of Ionones

  摘要：

  Violet smelling ionones 1-3, occurring in the headspace of different flowers, are well-known perfumery raw materials. With the goal to recognize the still ill-defined spatial arrangement of structural features relevant to the binding of ionones to olfactory G-protein coupled receptors, through B3LYP/6-31G(d) modeling studies we identified bicyclic compounds 7-9 as conformationally constrained 13-alkyl-substituted analogues of monocyclic alpha- and gamma-ionones. They were thus synthesized to evaluate the olfactory properties. The enantioselective syntheses of 7-9 entailed two common key steps: (i) a Diels-Alder reaction to construct the octalinic core and (ii) a Julia-Lythgoe olefination to install the alpha,beta-enone side chain. The odor thresholds of synthetic 7 and 9 were significantly lower than the corresponding parent ionones, and 9 showed the lowest threshold value among violet-smelling odorants examined so far. Modeling studies Suggested a nearly identical spatial orientation of key hydrophobic and polar moieties of compounds 1, 3, and 4-9. Presumably, interaction of these moieties with ionone olfactory receptors (ORs) triggers a similar receptor code that is ultimately interpreted by the human brain as a pleasant woody-violet smell. These results open the way to studies aimed at identifying and modeling complementary binding sites on alpha-helical domains of ionone receptor proteins.

  DOI：

  10.1021/jo9014936

文献信息

• Enantioselective Synthesis and Olfactory Evaluation of Bicyclic α- and γ-Ionone Derivatives: The 3D Arrangement of Key Molecular Features Relevant to the Violet Odor of Ionones
  作者：Marco Luparia、Laura Legnani、Alessio Porta、Giuseppe Zanoni、Lucio Toma、Giovanni Vidari

  DOI：10.1021/jo9014936

  日期：2009.9.18

  Violet smelling ionones 1-3, occurring in the headspace of different flowers, are well-known perfumery raw materials. With the goal to recognize the still ill-defined spatial arrangement of structural features relevant to the binding of ionones to olfactory G-protein coupled receptors, through B3LYP/6-31G(d) modeling studies we identified bicyclic compounds 7-9 as conformationally constrained 13-alkyl-substituted analogues of monocyclic alpha- and gamma-ionones. They were thus synthesized to evaluate the olfactory properties. The enantioselective syntheses of 7-9 entailed two common key steps: (i) a Diels-Alder reaction to construct the octalinic core and (ii) a Julia-Lythgoe olefination to install the alpha,beta-enone side chain. The odor thresholds of synthetic 7 and 9 were significantly lower than the corresponding parent ionones, and 9 showed the lowest threshold value among violet-smelling odorants examined so far. Modeling studies Suggested a nearly identical spatial orientation of key hydrophobic and polar moieties of compounds 1, 3, and 4-9. Presumably, interaction of these moieties with ionone olfactory receptors (ORs) triggers a similar receptor code that is ultimately interpreted by the human brain as a pleasant woody-violet smell. These results open the way to studies aimed at identifying and modeling complementary binding sites on alpha-helical domains of ionone receptor proteins.