2-methoxy-2-methyl-4-phenyl-1-phenylsulfonyl-1,2,3,4-tetrahydroquinoline | 1145656-06-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-methoxy-2-methyl-4-phenyl-1-phenylsulfonyl-1,2,3,4-tetrahydroquinoline
• 英文别名: 1-(Benzenesulfonyl)-2-methoxy-2-methyl-4-phenyl-3,4-dihydroquinoline；1-(benzenesulfonyl)-2-methoxy-2-methyl-4-phenyl-3,4-dihydroquinoline
• CAS: 1145656-06-9
• 化学式: C₂₃H₂₃NO₃S
• 分子量: 393.507
• InChiKey: FIUNFRJEILORBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methoxy-2-methyl-4-phenyl-1-phenylsulfonyl-1,2,3,4-tetrahydroquinoline 在 氢溴酸 作用下， 以 四氢呋喃 、 溶剂黄146 为溶剂， 反应 6.0h， 以84%的产率得到2-methyl-4-phenyl-1-phenylsulfonyl-1,4-dihydroquinoline
  参考文献：
  名称：

  Quinoline Derivatives by Cyclocondensation of N-(2-Bromophenylmethylphenyl)benzenesulfonamide with Enol Ethers and Enamines

  摘要：

  The reaction of N-(2-bromophenylmethylphenyl)benzenesulfonamide (1) with electron rich alkenes (enol ethers (2), (3) and enamines (4)) gives quinoline derivatives 5 and ring fused quinoline 6, 7 whose structures were assigned on the basis of analytical and spectroscopic data. The chemical behavior of adducts 5 and 7 is reported.

  DOI：

  10.3987/com-08-s(f)50
• 作为产物：
  描述：

  N-{2-[bromo(phenyl)methyl]phenyl}benzenesulfonamide 、 2-甲氧基丙烯 在 sodium hydride 作用下， 以 N,N-二甲基乙酰胺 、 mineral oil 为溶剂， 以75%的产率得到2-methoxy-2-methyl-4-phenyl-1-phenylsulfonyl-1,2,3,4-tetrahydroquinoline
  参考文献：
  名称：

  Quinoline Derivatives by Cyclocondensation of N-(2-Bromophenylmethylphenyl)benzenesulfonamide with Enol Ethers and Enamines

  摘要：

  The reaction of N-(2-bromophenylmethylphenyl)benzenesulfonamide (1) with electron rich alkenes (enol ethers (2), (3) and enamines (4)) gives quinoline derivatives 5 and ring fused quinoline 6, 7 whose structures were assigned on the basis of analytical and spectroscopic data. The chemical behavior of adducts 5 and 7 is reported.

  DOI：

  10.3987/com-08-s(f)50

文献信息

• Quinoline Derivatives by Cyclocondensation of N-(2-Bromophenylmethylphenyl)benzenesulfonamide with Enol Ethers and Enamines
  作者：Piero Dalla Croce、Giuseppe Cremonesi、Francesco Fontana、Concetta La Rosa

  DOI：10.3987/com-08-s(f)50

  日期：——

  The reaction of N-(2-bromophenylmethylphenyl)benzenesulfonamide (1) with electron rich alkenes (enol ethers (2), (3) and enamines (4)) gives quinoline derivatives 5 and ring fused quinoline 6, 7 whose structures were assigned on the basis of analytical and spectroscopic data. The chemical behavior of adducts 5 and 7 is reported.