N-(羧甲基氨基羰基)-4,4'-双(二甲氨基)二苯胺钠盐 | 115871-19-7

• 物质功能分类: 有机原料 - 有机金属类化合物 - 有机钠
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-(羧甲基氨基羰基)-4,4'-双(二甲氨基)二苯胺钠盐
• 英文名称: sodium N-(carboxymethyl)aminocarbonyl-4,4'-bis(dimethylamino)diphenylamine
• 英文别名: sodium salt of N,N-bis(4-dimethylaminophenyl)-N'-carboxymethylurea；N-(carboxymethylaminocarbonyl)-4,4'-bis(dimethylamino)diphenylamine sodium salt；Sodium 2-(3,3-bis(4-(dimethylamino)phenyl)ureido)acetate；sodium;2-[bis[4-(dimethylamino)phenyl]carbamoylamino]acetate
• CAS: 115871-19-7
• 化学式: C₁₉H₂₃N₄O₃*Na
• 分子量: 378.406
• InChiKey: VJGJSGZYXYOYQT-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.58
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  79
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 安全说明：
  S24/25
• 海关编码：
  29215900,2924299090
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335

反应信息

• 作为产物：
  描述：

  2-(3,3-bis(4-dimethylamino)phenyl)ureido ethyl acetate 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 17.0h， 以78.8%的产率得到N-(羧甲基氨基羰基)-4,4'-双(二甲氨基)二苯胺钠盐
  参考文献：
  名称：

  一种N-(羧甲基氨基羰基)-4,4′-双(二甲氨基)二苯胺钠盐的制备方法

  摘要：

  本发明提供一种N‑(羧甲基氨基羰基)‑4,4'‑双(二甲氨基)二苯胺钠盐的制备方法，包括共六个步骤，S1通过式Ⅱ所示化合物与多种化合物反应获得式Ⅲ所示化合物；S2通过式Ⅲ所示化合物与多种化合物反应获得式Ⅳ所示化合物；S3为式Ⅳ所示化合物通过还原反应获得式Ⅴ所示化合物；S4由甘氨酸Ⅵ通过酯化反应获得式Ⅶ所示化合物；S5由式Ⅶ所示化合物通过两步反应获得式Ⅸ所示化合物；S6由式Ⅸ所示化合物通过水解反应生成式Ⅰ所示N‑(羧甲基氨基羰基)‑4,4'‑双(二甲氨基)二苯胺钠盐。本发明使N‑(羧甲基氨基羰基)‑4,4'‑双(二甲氨基)二苯胺钠盐适于大规模的工业化生产，显著提高糖化血红蛋白酶法检测试剂盒底物的生产效率，降低此医药检测试剂盒的生产成本，以满足市场需求。

  公开号：

  CN114685318A

文献信息

• Alpha-glycated amino acid releasing enzyme
  申请人：ARKRAY, Inc.

  公开号：US20040247587A1

  公开（公告）日：2004-12-09

  The present invention relates to a novel enzyme (&agr;-GARE) which releases an amino acid residue having a glycated &agr;-amino group (&agr;-GA) from a glycated protein etc. and to bacterial strains producing the same. Examples of the bacterial strains include Sphingomonas parapaucimobilis KDK1004 (FERM BP-7041). The &agr;-GARE is contained in the culture supernatant of this strain and &agr;-GA can be released from a glycated peptide by using the same, as shown in FIG. 1.

  本发明涉及一种新型酶（α-GARE），该酶能够从糖化蛋白等中释放具有糖化α-氨基基团（α-GA）的氨基酸残基，并且涉及产生该酶的细菌菌株。这些细菌菌株的示例包括Sphingomonas parapaucimobilis KDK1004（FERM BP-7041）。α-GARE存在于该菌株的培养上清液中，并且如图1所示，可以使用它从糖化肽中释放α-GA。
• Method of measuring substance in sample using a redox reaction
  申请人：Kyoto Daiichi Kagaku Co., Ltd.

  公开号：US20020025546A1

  公开（公告）日：2002-02-28

  A highly reliable method of measuring an analyte in a sample using a redox reaction. In this method, a tetrazolium compound is added to a sample prior to the redox reaction so as to eliminate the influence of any reducing substance in the sample, then a reducing substance or an oxidizing substance derived from the analyte is formed, the quantity of the formed substance derived from the analyte is measured by the redox reaction, and the quantity of the analyte is determined from the quantity of the formed substance derived from the analyte. As the tetrazolium compound, for example, 2-(4-iodophenyl)-3-(2,4-dinitrophenyl)-5-(2,4-disulfophenyl)-2H-tetrazolium salt can be used.

  一种高度可靠的测量样品中分析物的方法，使用氧化还原反应。在该方法中，在氧化还原反应之前向样品中添加四唑化合物以消除样品中任何还原物质的影响，然后形成从分析物中衍生的还原物质或氧化物质，通过氧化还原反应测量从分析物中衍生的物质的数量，并从中确定分析物的数量。例如，可以使用2-（4-碘苯基）-3-（2,4-二硝基苯基）-5-（2,4-二硫酚基）-2H-四唑盐作为四唑化合物。
• Assay method with the use of redox reaction
  申请人：——

  公开号：US20040063213A1

  公开（公告）日：2004-04-01

  A method of determining an analyte in a sample utilizing a redox reaction is provided, by which a highly reliable determined value can be obtained. In this method, a tetrazolium compound is added to a sample in the presence of a surfactant prior to a redox reaction so as to eliminate an effect of hemoglobin and a hemoglobin degradation product as reducing substances in the sample. Thereafter, a reducing or oxidizing substance derived from an analyte is produced and the amount thereof is determined by the redox reaction. Then, the amount of the analyte in the sample is determined based on the amount of the reducing or oxidizing substance thus determined. According to this method, cloudiness due to the coexistence with the hemoglobin can be prevented by the surfactant and thus an increase in the absorbance due to the cloudiness can be inhibited as shown in FIG. 1 . As the surfactant, polyoxyethylene ether and the like can be used.

  提供了一种利用氧化还原反应确定样品中分析物的方法，可以获得高度可靠的确定值。在这种方法中，在氧化还原反应之前，在表面活性剂的存在下向样品中加入四唑化合物，以消除血红蛋白和血红蛋白降解产物作为还原物质对样品的影响。然后，由分析物产生的还原或氧化物质被产生，并通过氧化还原反应确定其数量。然后，根据确定的还原或氧化物质的数量确定样品中分析物的数量。根据这种方法，由于表面活性剂可以防止与血红蛋白的共存而导致的浑浊，因此可以像图1所示那样抑制由于浑浊而导致的吸光度增加。作为表面活性剂，可以使用聚氧乙烯醚等。
• METHOD FOR MEASURING TRIGLYCERIDE IN LOW-DENSITY LIPOPROTEIN AND KIT FOR MEASUREMENT
  申请人：Katayama Yuki

  公开号：US20090226944A1

  公开（公告）日：2009-09-10

  The present invention provides a method for a simple and accurate measurement of triglycerides in low-density lipoprotein in a sample comprising performing the following steps sequentially: (i) a step of generating free glycerol by allowing lipoprotein lipase to act on a sample, in an aqueous medium comprising the sample and a specific surfactant such as polyoxyethylene polyoxyalkylene polycyclic phenyl ether; (ii) a step of removing free glycerol present in the reaction solution of the above step (i); (iii) a step of generating free glycerol by allowing lipoprotein lipase to act on the reaction solution from which free glycerol has been removed in step (ii), in the presence of a specific surfactant such as polyoxyethylene polyoxyalkylene alkyl ether; and (iv) a step of measuring free glycerol generated in step (iii), and a kit used for the method.

  本发明提供了一种简单准确地测量样品中低密度脂蛋白中甘油三酯的方法，包括按照以下步骤顺序进行：(i)在包括样品和特定表面活性剂（例如聚氧乙烯聚氧烷基多环苯醚）的水介质中，使脂蛋白酯酶作用于样品，生成游离甘油；(ii)去除步骤(i)中反应溶液中存在的游离甘油；(iii)在去除步骤(ii)中的游离甘油的反应溶液中，使脂蛋白酯酶作用于特定表面活性剂（例如聚氧乙烯聚氧烷基烷基醚）的存在下，生成游离甘油；(iv)测量步骤(iii)中生成的游离甘油，以及用于该方法的试剂盒。
• Method of assaying bolld component by using whole blood and measurement kit
  申请人：Umegae Yoshihiki

  公开号：US20100075352A1

  公开（公告）日：2010-03-25

  [Problem] In quickly assaying a blood component interfered by glucose and/or its derivative on the bedside or in a clinic or in assaying the same by a patient in his/her own home, there has been required an assay method wherein the whole blood can be used as a sample as such without resorting to a centrifuge or the like. [Means For Solving Problems] A method of assaying a blood component to be used for assaying a blood component interfered by glucose and/or its derivative, characterized by comprising bringing the whole blood into contact with a substance capable of converting glucose and/or its derivative into another substance not interfering the assay and, simultaneously or subsequently, separating blood cells; a device to be used in the assay method; and a kit containing this device.

  【问题】在床边或诊所中快速检测被葡萄糖和/或其衍生物干扰的血液成分，或者在患者自己的家中进行检测，需要一种检测方法，可以使用全血作为样本，而不需要离心机或类似设备。【解决问题的方法】一种检测血液成分的方法，用于检测被葡萄糖和/或其衍生物干扰的血液成分，其特征在于将全血与能够将葡萄糖和/或其衍生物转化为不干扰检测的另一种物质接触，并同时或随后分离血细胞；用于该检测方法的设备；以及包含该设备的试剂盒。