苯胺基乙酸钾 | 19525-59-8

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 羧酸酯及其衍生物的盐
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 苯胺基乙酸钾
• 中文别名: N-苯基甘氨酸钾盐；左旋苯甘氨酸邓钾盐(乙基)
• 英文名称: 2-Anilinoacetic acid; potassium
• CAS: 19525-59-8
• 化学式: C8H9KNO2
• 分子量: 190.26
• InChiKey: CZNJCUMJHDYOHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xi
• WGK Germany：
  3
• 海关编码：
  2922499990
• 安全说明：
  S22,S24/25
• 危险类别码：
  R36/37/38
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

制备方法与用途

用途：该染料主要应用于生产还原染料，并广泛用于制造氨苄青霉素、氧哌嗪青霉素、头孢氨苄及头孢氯氨苄等药物。

文献信息

• SPIRO AND DISPIRO 1,2,4-TRIOXOLANE ANTIMALARIALS
  申请人：VENNERSTROM JONATHAN L.

  公开号：US20080125441A1

  公开（公告）日：2008-05-29

  A means and method for treating malaria, schistosomiasis, and cancer using a Spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.

  本发明涉及使用Spiro或dispiro 1,2,4-三噁烷治疗疟疾、血吸虫病和癌症的方法和手段。首选的1,2,4-三噁烷包括一个spiroadamantane基团位于三噁烷基团的一侧，而spirocyclohexyl位于三噁烷基团的另一侧，其中spirocyclohexyl环在4位处被取代。与青蒿素半合成衍生物相比，本发明化合物结构简单，易于合成，无毒，并且对疟原虫具有强效作用。
• DENTAL CURABLE COMPOSITION AND KIT FOR SUCH DENTAL CURABLE COMPOSITION
  申请人：SUN MEDICAL CO., LTD.

  公开号：EP1938781A1

  公开（公告）日：2008-07-02

  [Means for solution] A dental curable composition has a curing time of 30 seconds to 120 minutes and includes a compound having an acidic group in the molecule (A), a polymerizable monomer (B), an organic amine compound (C) and a sulfur-containing reducing compound (D). In the dental curable composition, the content of the component (A) is 0.01 to 80 parts by weight, the content of the component (B) is 21 to 99.8 parts by weight, the content of the component (C) is 0.01 to 30 parts by weight and the content of the component (D) is 0 to 30 parts by weight (the total of the components (A) to (D) is 100 parts by weight. When any of the compounds belongs to a plurality of the components (A) to (D), the parts by weight of the compound is divided by the number of the components to which the compound belongs, and the quotient is used as the content of each component). [Advantage] The composition may be cured at a relatively low temperature close to the body temperature without using a peroxide-based polymerization initiator, and has good sealing property and adhesion.

  [解决方法］ 一种牙科固化组合物的固化时间为30秒至120分钟，包括分子中含有酸性基团的化合物(A)、可聚合单体(B)、有机胺化合物(C)和含硫还原化合物(D)。在牙科固化组合物中，组分（A）的含量为 0.01 至 80 份（按重量计），组分（B）的含量为 21 至 99.8 份（按重量计），组分（C）的含量为 0.01 至 30 份（按重量计），组分（D）的含量为 0 至 30 份（按重量计）（组分（A）至（D）的总和为 100 份（按重量计））。当任何一种化合物属于多种组分（A）至（D）时，该化合物的重量份数除以该化合物所属组分的数量，所得之商作为各组分的含量）。 优势 该组合物可在接近人体温度的相对低温下固化，无需使用过氧化物基聚合引发剂，并具有良好的密封性和粘合性。
• EASILY REMOVABLE CURABLE COMPOSITION FOR DENTAL USE
  申请人：SUN MEDICAL CO., LTD.

  公开号：EP2491915A1

  公开（公告）日：2012-08-29

  A dental curable composition whose polymerization is not impeded even in a moist environment and in the presence of oxygen and which has excellent marginal sealability and enables the provision of flexibility and the control of removability. The dental curable composition comprises (A) a polymerizable monomer and (B) an organic amine-based polymerization initiator, wherein (A') a long-chain polymerizable monomer having a chain length of 17 or more atoms is contained in the component (A) and/or (C) a soft resin material are/is contained in the composition, and when the amount (parts by weight) based on 100 parts by weight of the component (A) of the component (Aʹ) is represented by [aʹ] and the amounts (parts by weight) based on 100 parts by weight of the total of the components (A) and (B) of the components (A), (B) and (C) are represented by (a), (b) and (c), respectively, 70 ≦ (a) ≦ 99.99, 0.01 ≦ (b) ≦ 30,1 ≦ [aʹ]/5 + (c)/1, 0 ≦ [aʹ] ≦ 95, and 0 ≦ (c) ≦ 250.

  一种牙科固化组合物，其聚合即使在潮湿环境和有氧气存在的情况下也不会受阻，具有极佳的边缘密封性，并能提供柔韧性和控制可移除性。 牙科固化组合物包括 (A) 可聚合单体和 (B) 有机胺类聚合引发剂，其中 (A') 组分 (A) 中含有链长为 17 个或更多原子的长链可聚合单体，和/或 (C) 组合物中含有软树脂材料、当组分(Aʹ)中基于 100 份重量的组分(A)的量(重量份数)用[aʹ]表示，组分(A)、(B)和(C)中基于 100 份重量的组分(A)和(B)总量的量(重量份数)分别用(a)、(b)和(c)表示时，70 ≦ (a) ≦ 99.99，0.01 ≦ (b) ≦ 30，1 ≦ [aʹ]/5 + (c)/1，0 ≦ [aʹ] ≦ 95，0 ≦ (c) ≦ 250。
• Dental Curable Composition and Kit for Such Dental Curable Composition
  申请人：Ori Tatsuya

  公开号：US20090137697A1

  公开（公告）日：2009-05-28

  A dental curable composition has a curing time of 30 seconds to 120 minutes and includes a compound having an acidic group in the molecule (A), a polymerizable monomer (B), an organic amine compound (C) and a sulfur-containing reducing compound (D). In the dental curable composition, the content of the component (A) is 0.01 to 80 parts by weight, the content of the component (B) is 21 to 99.8 parts by weight, the content of the component (C) is 0.01 to 30 parts by weight and the content of the component (D) is 0 to 30 parts by weight. The composition may be cured at a relatively low temperature close to the body temperature without using a peroxide-based polymerization initiator, and has good sealing properties and adhesion.
• REMOVABLE DENTAL CURABLE COMPOSITION
  申请人：Ori Tatsuya

  公开号：US20120213832A1

  公开（公告）日：2012-08-23

  A dental curable composition comprises (A) a polymerizable monomer and (B) an organic amine-based polymerization initiator, wherein (A′) a long-chain polymerizable monomer having a chain length of 17 or more atoms is contained in the component (A) and/or (C) a soft resin material are/is contained in the composition, and when the amount (parts by weight) based on 100 parts by weight of the component (A) of the component (A′) is represented by [a′] and the amounts (parts by weight) based on 100 parts by weight of the total of the components (A) and (B) of the components (A), (B) and (C) are represented by (a), (b) and (c), respectively, 70≦(a)≦99.99, 0.01≦(b)≦5 30, 1≦[a′]/5+(c)/1, 0≦[a′]≦95, and 0≦(c)≦250.