7-azido-1,4-dioxaspiro[4.4]nonane | 1322805-38-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-azido-1,4-dioxaspiro[4.4]nonane
• 英文别名: 8-Azido-1,4-dioxaspiro[4.4]nonane
• CAS: 1322805-38-8
• 化学式: C₇H₁₁N₃O₂
• 分子量: 169.183
• InChiKey: GSZISZIWUCITEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-azido-1,4-dioxaspiro[4.4]nonane 在 supported Candida antartica lipase B 、 5 wt% Pd/C 、 氢气 作用下， 以 甲醇 、 乙醚 、 甲基叔丁基醚 、 2,2,2-三氟乙酰胺 为溶剂， 38.0~40.0 ℃ 、101.33 kPa 条件下， 反应 24.0h， 生成
  参考文献：
  名称：

  Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines Catalyzed by CAL-B at 38–40 °C

  摘要：

  The (R)-selective chemoenzymatic dynamic kinetic resolution of primary amines was performed at 38-40 degrees C in MTBE, in good to high yields and with high enantiomeric excesses. These reactions associating CAL-B to octanethiol as radical racemizing agent were carried out in the presence of methyl beta-methoxy propanoate as acyl donor, under photochemical irradiation at 350 nm in glassware.

  DOI：

  10.1021/jo201256w
• 作为产物：
  描述：

  2-环戊烯酮 、 乙二醇 在 三甲基氯硅烷 、 sodium azide 作用下， 以 二氯甲烷 为溶剂， 反应 8.25h， 以58%的产率得到7-azido-1,4-dioxaspiro[4.4]nonane
  参考文献：
  名称：

  Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines Catalyzed by CAL-B at 38–40 °C

  摘要：

  The (R)-selective chemoenzymatic dynamic kinetic resolution of primary amines was performed at 38-40 degrees C in MTBE, in good to high yields and with high enantiomeric excesses. These reactions associating CAL-B to octanethiol as radical racemizing agent were carried out in the presence of methyl beta-methoxy propanoate as acyl donor, under photochemical irradiation at 350 nm in glassware.

  DOI：

  10.1021/jo201256w

文献信息

• Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines Catalyzed by CAL-B at 38–40 °C
  作者：Florent Poulhès、Nicolas Vanthuyne、Michèle P. Bertrand、Stéphane Gastaldi、Gérard Gil

  DOI：10.1021/jo201256w

  日期：2011.9.2

  The (R)-selective chemoenzymatic dynamic kinetic resolution of primary amines was performed at 38-40 degrees C in MTBE, in good to high yields and with high enantiomeric excesses. These reactions associating CAL-B to octanethiol as radical racemizing agent were carried out in the presence of methyl beta-methoxy propanoate as acyl donor, under photochemical irradiation at 350 nm in glassware.