(S)-1,4-dioxaspiro[4.4]nonan-7-amine | 1322805-36-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-1,4-dioxaspiro[4.4]nonan-7-amine
• 英文别名: (S)-1,4-Dioxaspiro[4.4]nonan-7-amine；(8S)-1,4-dioxaspiro[4.4]nonan-8-amine
• CAS: 1322805-36-6
• 化学式: C₇H₁₃NO₂
• 分子量: 143.186
• InChiKey: FTUCRLHGAZBPBK-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  44.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-甲基-双(三氟乙酰胺) 、 (S)-1,4-dioxaspiro[4.4]nonan-7-amine 以 2,2,2-三氟乙酰胺 为溶剂， 生成
  参考文献：
  名称：

  Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines Catalyzed by CAL-B at 38–40 °C

  摘要：

  The (R)-selective chemoenzymatic dynamic kinetic resolution of primary amines was performed at 38-40 degrees C in MTBE, in good to high yields and with high enantiomeric excesses. These reactions associating CAL-B to octanethiol as radical racemizing agent were carried out in the presence of methyl beta-methoxy propanoate as acyl donor, under photochemical irradiation at 350 nm in glassware.

  DOI：

  10.1021/jo201256w
• 作为产物：
  描述：

  7-azido-1,4-dioxaspiro[4.4]nonane 在 supported Candida antartica lipase B 、 5 wt% Pd/C 、 氢气 作用下， 以 甲醇 、 乙醚 、 甲基叔丁基醚 为溶剂， 38.0~40.0 ℃ 、101.33 kPa 条件下， 反应 24.0h， 生成 (S)-1,4-dioxaspiro[4.4]nonan-7-amine
  参考文献：
  名称：

  Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines Catalyzed by CAL-B at 38–40 °C

  摘要：

  The (R)-selective chemoenzymatic dynamic kinetic resolution of primary amines was performed at 38-40 degrees C in MTBE, in good to high yields and with high enantiomeric excesses. These reactions associating CAL-B to octanethiol as radical racemizing agent were carried out in the presence of methyl beta-methoxy propanoate as acyl donor, under photochemical irradiation at 350 nm in glassware.

  DOI：

  10.1021/jo201256w

文献信息

• Aryl, Heteroaryl, and Heterocyclic Compounds for Treatment of Medical Disorders
  申请人：Achillion Pharmaceuticals, Inc.

  公开号：US20170066783A1

  公开（公告）日：2017-03-09

  Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R 12 or R 13 on the A group is an aryl, heteroaryl or heterocycle (R 32 ) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.
• Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines Catalyzed by CAL-B at 38–40 °C
  作者：Florent Poulhès、Nicolas Vanthuyne、Michèle P. Bertrand、Stéphane Gastaldi、Gérard Gil

  DOI：10.1021/jo201256w

  日期：2011.9.2

  The (R)-selective chemoenzymatic dynamic kinetic resolution of primary amines was performed at 38-40 degrees C in MTBE, in good to high yields and with high enantiomeric excesses. These reactions associating CAL-B to octanethiol as radical racemizing agent were carried out in the presence of methyl beta-methoxy propanoate as acyl donor, under photochemical irradiation at 350 nm in glassware.