N-乙酰-D-正缬氨酸 | 57357-56-9

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 缬氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: N-乙酰-D-正缬氨酸
• 中文别名: N-乙酰基-D-正缬氨酸
• 英文名称: N-acetyl-D-norvaline
• 英文别名: N-Acetyl-D-norvalin；N-Acetyl-D-Norvaline；(2R)-2-acetamidopentanoic acid
• CAS: 57357-56-9
• 化学式: C₇H₁₃NO₃
• 分子量: 159.185
• InChiKey: BSYFPUSAWVWWDG-ZCFIWIBFSA-N

物化性质

• 沸点：
  371.8±25.0 °C(Predicted)
• 密度：
  1.097±0.06 g/cm3(Predicted)
• 稳定性/保质期：

  如果按照规格使用和储存，则不会分解，且未有已知危险反应。

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 安全说明：
  S24/25
• WGK Germany：
  3
• 海关编码：
  2924199090
• 储存条件：
  请将贮藏器保持密封，并存放在阴凉干燥处。同时确保工作环境有良好的通风或排气设施。

制备方法与用途

N-乙酰-D-羟缬氨酸是一种缬氨酸衍生物。

反应信息

• 作为反应物：
  描述：

  N-乙酰-D-正缬氨酸 、 碘苯二乙酸 以 氯苯 为溶剂， 生成 (Di-N-acetyl-D-norvalyloxyjod)-benzol
  参考文献：
  名称：

  Merkushev,E.B. et al., Journal of Organic Chemistry USSR (English Translation), 1975, vol. 11, p. 1246 - 1249

  摘要：

  DOI：
• 作为产物：
  描述：

  N-乙酰-DL-正缬氨酸 生成 N-乙酰-D-正缬氨酸
  参考文献：
  名称：

  l-methionine related l-amino acids by acylase cleavage of their corresponding

  摘要：

  Acylase I from Aspergillus oryzae is an even more useful enzyme than suggested so far. Besides standard amino acids such as L-Met, L-VaI and L-Phe, a number of additional sulfur-and selenium-containing amino acids can be obtained at useful reaction rates and in very high enantiomeric purity by kinetic resolution of the respective N-acety-DL-amino acids. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00400-x

文献信息

• Efficient kinetic resolution of amino acids catalyzed by lipase AS ‘Amano’ via cleavage of an amide bond
  作者：Bo Wang、Yanfeng Liu、Dela Zhang、Yuhong Feng、Jiacheng Li

  DOI：10.1016/j.tetasy.2012.08.017

  日期：2012.10

  Herein the efficient kinetic resolution of non-natural alpha-amino acids catalyzed by lipase AS 'Amano' via cleaving the amide bond is reported. The starting materials were the corresponding amino acid amides and the amino acids were generated with ees of up to 99% with E values of > 600. These results indicated that the lipase AS 'Amano' could be a powerful amide hydrolase for the kinetic resolution of amino acid starting from the corresponding amino acid amides. (C) 2012 Elsevier Ltd. All rights reserved.
• Kinetic resolution of unnatural and rarely occurring amino acids: enantioselective hydrolysis of N-acyl amino acids catalyzed by acylase I
  作者：H. Keith Chenault、Juergen Dahmer、George M. Whitesides

  DOI：10.1021/ja00198a055

  日期：1989.8
• Cobalt Ion Activation of Renal Acylase I
  作者：Robin Marshall、Sanford M. Birnbaum、Jesse P. Greenstein

  DOI：10.1021/ja01599a030

  日期：1956.9
• ALLOSTERIC CHAPERONES AND USES THEREOF
  申请人：Fondazione Telethon

  公开号：US20150147309A1

  公开（公告）日：2015-05-28

  The present invention relates to an allosteric non-inhibitory chaperone of the lysosomal acid alpha-glucosidase (GAA) for use in the treatment of a pathological condition characterized by a deficiency of the lysosomal acid alpha-glucosidase (GAA), to pharmaceutical composition thereof, to a method for increasing the activity of GAA in a subject and to a method for identifying an allosteric non-inhibitory chaperone for GAA.