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N-L-leucyl-L-aspartic acid | 32949-40-9

中文名称
——
中文别名
——
英文名称
N-L-leucyl-L-aspartic acid
英文别名
Leu-Asp;H-Leu-Asp-OH;(2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]butanedioic acid
<i>N</i>-L-leucyl-L-aspartic acid化学式
CAS
32949-40-9
化学式
C10H18N2O5
mdl
——
分子量
246.263
InChiKey
DVCSNHXRZUVYAM-BQBZGAKWSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    461.0±45.0 °C(Predicted)
  • 密度:
    1.272±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    -3.9
  • 重原子数:
    17
  • 可旋转键数:
    7
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.7
  • 拓扑面积:
    130
  • 氢给体数:
    4
  • 氢受体数:
    6

SDS

SDS:cf89f22438d96de18ea79f4b9c3ed092
查看

反应信息

  • 作为反应物:
    描述:
    N-L-leucyl-L-aspartic acid 、 zinc(II) acetate dihydrate 以 乙醇 为溶剂, 反应 24.0h, 以25%的产率得到[Zn(Leu-Asp)]
    参考文献:
    名称:
    Leucine zipper motif inspiration: a two-dimensional leucine Velcro-like array in peptide coordination polymers generates hydrophobicity
    摘要:
    通过2D-Velcro样的亮氨酸阵列,肽基配位层的包装使得得到疏水材料成为可能。
    DOI:
    10.1039/c7dt02153d
  • 作为产物:
    参考文献:
    名称:
    Ohyama, Satoshi; Ishibashi, Norio; Tamura, Masahiro, Agricultural and Biological Chemistry, 1988, vol. 52, # 3, p. 871 - 872
    摘要:
    DOI:
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文献信息

  • Peptide Synthesis in Aqueous Solution. I. Application of<i>p</i>-Dialkylsulfoniophenols as a Water-Soluble Coupling Reagent
    作者:Katsushige Kouge、Tatsuya Koizumi、Hideo Okai、Tetsuo Kato
    DOI:10.1246/bcsj.60.2409
    日期:1987.7
    found to be an excellent coupling reagent having a water-soluble property and a high reactivity; it worked as satisfactory as usual active esters in regard to the reactivity, product purity, and racemization. The marked advantage of the HODMSP·MeSO4− active ester method was the fact that bifunctional residues such as Arg, Lys, Cys, and Tyr could be selectively acylated when the pH of the reaction mixture
    发现(对羟基苯基)二甲基锍甲基硫酸盐(HODMSP·MeSO4-)是一种优良的偶联剂,具有水溶性和高反应性;在反应性、产品纯度和外消旋化方面,它与通常的活性酯一样令人满意。HODMSP·MeSO4-活性酯法的显着优势在于,当反应混合物的pH值得到控制时,双功能残基如Arg、Lys、Cys和Tyr可以被选择性地酰化。通过这种新的活性酯方法合成了软体动物神经肽 FMRFamide(Phe-Met-Arg-Phe-NH2),以评估该方法在涉及肽合成的进一步应用中的应用。
  • Chemical isotope labeling-assisted liquid chromatography-mass spectrometry enables sensitive and accurate determination of dipeptides and tripeptides in complex biological samples
    作者:Feng-Qing Huang、Yu Wang、Ji-Wen Wang、Dai Yang、Shi-Lei Wang、Yuan-Ming Fan、Raphael N. Alolga、Lian-Wen Qi
    DOI:10.1016/j.cclet.2024.109670
    日期:2024.2
    their unique features and diverse biological functions. Achieving rapid separation and accurate quantification, however, remains a challenge because of their low abundance and the co-existence of numerous structural isomers. In this study, we developed a novel approach using isotope chemical labeling for ultrasensitive determination of di/tripeptides in biological samples. We successfully synthesized a
    小肽因其独特的特性和多样化的生物学功能而受到越来越多的关注。然而,由于其丰度低且存在多种结构异构体,实现快速分离和准确定量仍然是一个挑战。在这项研究中,我们开发了一种使用同位素化学标记超灵敏测定生物样品中二肽/三肽的新方法。我们成功合成了一种新型衍生化试剂4-(2-(乙氧基亚甲基)-3-氧代丁酰胺基)-三甲基苯胺碘化物(EOTMBA)及其氘标记同位素试剂(-EOTMBA)。总共97个小肽,包括89个二肽和8个三肽,在60℃下1.5小时内可以在​​甲醇中完全衍生化。 EOTMBA 标记后,通过 LC-MS/MS 分析在 22 分钟内完成对这些二肽/三肽的分析。该方法的准确度为 86.3%–113%,定量限范围为 0.25 fmol/L 至 5 nmol/L。利用该方法,我们对取自健康个体和胆道疾病患者的 147 份血浆、49 份尿液和 46 份胆汁样本中的二肽/三肽进行了超灵敏和准确的定量。
  • Structure, Mechanism, and Substrate Profile for Sco3058: The Closest Bacterial Homologue to Human Renal Dipeptidase,
    作者:Jennifer A. Cummings、Tinh T. Nguyen、Alexander A. Fedorov、Peter Kolb、Chengfu Xu、Elena V. Fedorov、Brian K. Shoichet、David P. Barondeau、Steven C. Almo、Frank M. Raushel
    DOI:10.1021/bi901935y
    日期:2010.1.26
    Human renal dipeptidase, an enzyme associated With glutathione metabolism and the hydrolysis of beta-lactams, is similar in sequence to a cluster of similar to 400 microbial proteins currently annotated as nonspecific dipeptidases within the amidohydrolase superfamily. The closest homologue to the human renal dipeptidase from a Fully sequenced microbe is Sco3058 from Streptomyces coelicolor. Dipeptide Substrates of Sco3058 were identified by screening a comprehensive series Of L-Xaa-L-Xaa, L-Xaa-D-Xaa, and D-Xaa-L-Xaa dipeptide libraries. The substrate specificity profile shows that Sco3058 hydrolyzes a broad range of dipeptides with a marked preference for all L-amino acid at the N-terminus and a D-amino acid at the C-terminus. The best Substrate identified was L-Arg-D-Asp (k(eat)/K-m = 7.6 x 10(5) M-1 s(-1)). The three-dimensional structure of Sco3058 was determined in the absence and presence of the inhibitors citrate and a phosphinate mimic Of L-Ala-D-Asp. The enzyme folds as (beta/alpha)(8) barrel, and two zinc Ions are bound in the active site. Site-directed mutagenesis was used to probe the importance of specific residues that have direct interactions with the substrate analogues in the active site (Asp-22, His-150, Arg-223, and Asp-320). The solvent viscosity and kinetic effects of D2O indicate that Substrate binding is relatively sticky and that proton transfers do not occur during the rate-limiting step. A bell-shaped pH-rate profile for k(cat) and k(cat)/k(m) indicated that one group needs to he deprotonated and a second group Must be protonated for optimal turnover. Computational docking of high-energy intermediate forms Of L/D-Ala-L/D-Ala to the three-dimensional Structure of Sco3058 identified the Structural determinants for the stereochemical preferences for Substrate binding and turnover.
  • Consden; Gordon; Martin, Biochemical Journal, 1949, vol. 44, p. 557
    作者:Consden、Gordon、Martin
    DOI:——
    日期:——
  • HETEROCYCLIC DERIVATIVES AND THEIR USE AS INTEGRIN INHIBITORS
    申请人:AstraZeneca AB
    公开号:EP1133484A2
    公开(公告)日:2001-09-19
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