肾上腺皮质激素类药
肾上腺皮质激素是肾上腺皮质分泌的一类固醇化合物，主要分为三类：盐皮质激素由球状带分泌，包括醛固酮和去氧皮质酮等；糖皮质激素由束状带合成与分泌，如氢化可的松和可的松等，其分泌受促肾上腺皮质激素（ACTH）调节；性激素则由网状带分泌。临床上常用的肾上腺皮质激素主要是指糖皮质激素。
生理状态下，糖皮质激素主要影响物质代谢过程；而超生理剂量时，则表现出显著的抗炎和抗免疫等药理作用。ACTH是维持肾上腺正常形态与功能的关键激素。其合成与分泌在下丘脑促皮质素释放激素（CRH）的作用下，在垂体前叶嗜碱细胞内进行。
糖皮质激素对下丘脑及垂体前叶产生长负反馈，抑制CRH和ACTH的分泌。在正常生理情况下，下丘脑、垂体与肾上腺三者保持相对动态平衡；当ACTH缺乏时，则会导致肾上腺皮质萎缩和分泌功能减退。此外，ACTH还具有控制自身释放的短负反馈调节作用。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| 倍他米松二丙酸酯 | betamethasone dipropionate | 5593-20-4 | C28H37FO7 |
|
| 倍他米松 | betamethasone | 378-44-9 | C22H29FO5 |
|
| 二氟拉松 | Diflorasone | 2557-49-5 | C22H28F2O5 |
|
| 丙酸氯倍他索 | clobetasol-17-propionate | 25122-46-7 | C25H32ClFO5 |
|
| 丙酸倍氯米松 | beclomethasone 17,21-dipropionate | 5534-09-8 | C28H37ClO7 |
|
| 丁酸氢化可的松 | hydrocortisone 17α-butyrate | 13609-67-1 | C25H36O6 |
|
| DL-苏氨酸-维他命酸异丙酯 | Isopropyl-<α-phenyl-α-(2-piperidyl)>acetat | 93148-46-0 | C16H23NO2 |
|
| 16alpha-羟基泼尼松龙 | desonide | 13951-70-7 | C21H28O6 |
|
| —— | [(8S,9S,10R,11R,13S,14S,17R)-11-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] butanoate | 1231185-35-5 | C25H36O6 |
|
| —— | 6000-74-4 | C21H31NaO8P |
|
|
| —— | 125-02-0 | C21H29NaO8P |
|
|
| —— | 16α-Hydroxy-prednisolon | 13951-70-7 | C21H28O6 |
|
| —— | Clobetasol propionate | 25122-46-7 | C25H32ClFO5 |
|
| —— | (8S,9R,10S,11S,13S,14S,16R,17R)-17-(2-chloroacetyl)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one | 25122-41-2 | C22H28ClFO4 |
|
| —— | 2-chloro-6β,9α-difluoro-11β,17α,21-trihydroxy-16β-methyl-pregna-1,4-diene-3,20-dione | 50629-82-8 | C22H27ClF2O5 |
|
| —— | Prednisolon-dinatriumphosphat | 125-02-0 | C21H27O8P*2Na |
|
| —— | 6α-Fluoro-11β,21-dihydroxy-3,20-dioxo-16α-methylpregna-1,4-dien | 152-97-6 | C22H29FO4 |
|
| —— | 2392-39-4 | C22H30FNaO8P |
|
|
| —— | Dexamethasone valerate | 2152-44-5 | C27H37FO6 |
|
| —— | [2-[(9R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate | 987-24-6 | C24H31FO6 |
|
| —— | (1S,2S,4R,8S,9S,11S,13R)-11-hydroxy-8-(2-hydroxyacetyl)-9,13-dimethyl-6-propyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one | 51333-22-3 | C25H34O6 |
|
| —— | 4-[2-(11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy]-4-oxobutanoic acid;hydrate | 83784-20-7 | C25H36O9 |
|
| —— | S-(fluoromethyl) 6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate | 90566-53-3 | C22H27F3O4S |
|
| —— | Pharmakon1600-01503273 | 13609-67-1 | C25H36O6 |
|
| —— | Pharmakon1600-01503210 | 5593-20-4 | C28H37FO7 |
|
| —— | [(6S,8S,9R,10S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate | 80474-14-2 | C25H31F3O5S |
|
| —— | (8S,9S,10R,11S,13S,14S,17R)-11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl butyrate | 13609-67-1 | C25H36O6 |
|
| —— | beta-Methasone 17,21-dipropionate | 5593-20-4 | C28H37FO7 |
|
| —— | S-Fluoromethyl 6α,9α-Difluoro-11β-hydroxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate | 80474-14-2 | C25H31F3O5S |
|
| —— | prednisolone sodium succinate | 1715-33-9 | C25H31O8*Na |
|
| —— | Celestone Phosphate | 151-73-5 | C22H30FNaO8P+ |
|
| —— | fluocinolone acetonide | 67-73-2 | C24H30F2O6 |
|
| —— | 9α-Fluor-11,17α,21-trihydroxy-pregnen-(4)-dion-(3,20) | 127-31-1 | C21H29FO5 |
|
| —— | (-)-m-octopamine | 636-87-3 | C8H11NO2*ClH |
|
| —— | [2-[(9R,10S,11S,13S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-propanoyloxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] propanoate | 5593-20-4 | C28H37FO7 |
|
| —— | 16α-Methyl-9α-fluoroprednisolon 21-phosphate | 312-93-6 | C22H30FO8P |
|
| —— | 9α-Fluor-11β,17α-dihydroxy-21-phosphonooxy-16α-methyl-pregnadien-(1.4)-dion-(3.20) | 312-93-6 | C22H30FO8P |
|
| —— | 11β.17α.21-Trihydroxy-3.20-dioxo-6α-methyl-pregnadien-(1.4) | 83-43-2 | C22H30O5 |
|
| —— | 9α-Fluor-11β,21-dihydroxy-16α,17α-isopropylidendioxy-pregn-1.4-dien-3,20-dion, Triamcinolon-acetonid | 76-25-5 | C24H31FO6 |
|
| —— | Prednisolon-21-acetat | 52-21-1 | C23H30O6 |
|
| —— | cortisone acetate | 50-04-4 | C23H30O6 |
|
| —— | Acetic acid 2-((10R,13S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl ester | 50-04-4 | C23H30O6 |
|
| —— | 17α,21-Dihydroxy-16β-methyl-1,4-pregnadien-3,11,20-trion | 1247-42-3 | C22H28O5 |
|
| —— | desoxycortone | 64-85-7 | C21H30O3 |
|
| —— | deoxycorticosterone | 64-85-7 | C21H30O3 |
|
| —— | cortisone | 53-06-5 | C21H28O5 |
|
| —— | dexamethasone-21-acetate | 1177-87-3 | C24H31FO6 |
|
| —— | dexamethasone | 50-02-2 | C22H29FO5 |
|
| —— | 9-fluoro-11β,17,21-trihydroxy-16β-methyl-pregna-1,4-diene-3,20-dione | 50-02-2 | C22H29FO5 |
|
| —— | dexamethasone | 50-02-2 | C22H29FO5 |
|
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