肾上腺皮质激素类药
肾上腺皮质激素是肾上腺皮质分泌的一类固醇化合物，主要分为三类：盐皮质激素由球状带分泌，包括醛固酮和去氧皮质酮等；糖皮质激素由束状带合成与分泌，如氢化可的松和可的松等，其分泌受促肾上腺皮质激素（ACTH）调节；性激素则由网状带分泌。临床上常用的肾上腺皮质激素主要是指糖皮质激素。
生理状态下，糖皮质激素主要影响物质代谢过程；而超生理剂量时，则表现出显著的抗炎和抗免疫等药理作用。ACTH是维持肾上腺正常形态与功能的关键激素。其合成与分泌在下丘脑促皮质素释放激素（CRH）的作用下，在垂体前叶嗜碱细胞内进行。
糖皮质激素对下丘脑及垂体前叶产生长负反馈，抑制CRH和ACTH的分泌。在正常生理情况下，下丘脑、垂体与肾上腺三者保持相对动态平衡；当ACTH缺乏时，则会导致肾上腺皮质萎缩和分泌功能减退。此外，ACTH还具有控制自身释放的短负反馈调节作用。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| —— | betamethasone | 50-02-2 | C22H29FO5 |
|
| —— | (9R,16R,17R)-9-Fluoro-11,17-dihydroxy-17-(2-hydroxy-acetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-cyclopenta[a]phenanthren-3-one | 50-02-2 | C22H29FO5 |
|
| —— | Budesonid | 51333-22-3 | C25H34O6 |
|
| —— | Fludrocortisone acetate | 514-36-3 | C23H31FO6 |
|
| —— | 9α-Fluorocortisone acetate | 514-36-3 | C23H31FO6 |
|
| —— | prednisolone | 50-24-8 | C21H28O5 |
|
| —— | Triamcinolon | 124-94-7 | C21H27FO6 |
|
| —— | dexamethasone | 124-94-7 | C21H27FO6 |
|
| —— | acetic acid 2-((10R,13S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl ester | 125-10-0 | C23H28O6 |
|
| —— | 21-acetoxy-17-hydroxy-pregna-1,4-diene-3,11,20-trione | 125-10-0 | C23H28O6 |
|
| —— | 11β-Hydroxy-3.20-dioxo-Δ<sup>1,4</sup>-pregnadien<17α.16α-d><2'-methyl-oxazolin> | 13649-88-2 | C23H29NO4 |
|
| —— | prednisone | 53-03-2 | C21H26O5 |
|
| —— | Cortisol | 50-23-7 | C21H30O5 |
|
| —— | hydrocortisone sodium succinate | 125-04-2 | C25H33O8*Na |
|
| —— | 11β,17,21-trihydroxy-pregn-4-ene-3,20-dione | 50-23-7 | C21H30O5 |
|
| —— | Hydrocortison | 50-23-7 | C21H30O5 |
|
| —— | cortisol | 50-23-7 | C21H30O5 |
|
| —— | deoxycortone | 64-85-7 | C21H30O3 |
|
| —— | 6,9-Difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoandrosta-1,4-dien-17-yl propanoate | 80474-14-2 | C25H31F3O5S |
|
| —— | bestASONe | 356-12-7 | C26H32F2O7 |
|
| —— | Betnesol | 312-93-6 | C22H30FO8P |
|
| —— | 21-acetoxy-pregn-4-ene-3,20-dione | 56-47-3 | C23H32O4 |
|
| —— | 6b-Glycoloyl-5-hydroxy-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one | 51372-29-3 | C25H34O6 |
|
| —— | Methylprednisolone | 83-43-2 | C22H30O5 |
|
| —— | medrol acetate | 53-36-1 | C24H32O6 |
|
| —— | 17,21-dihydroxy-pregn-4-ene-3,11,20-trione | 53-06-5 | C21H28O5 |
|
| —— | Blephamide S.O.P. | 52-21-1 | C23H30O6 |
|
| —— | Beconase AQ | 5534-09-8 | C28H37ClO7 |
|
| —— | [11-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] butanoate | 13609-67-1 | C25H36O6 |
|
| —— | Dexamethasone-21-acetate | 987-24-6 | C24H31FO6 |
|
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