Celestone Phosphate | 151-73-5

• 物质功能分类: 原料药 - 激素及调节内分泌功能类药 - 肾上腺皮质激素类药
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Celestone Phosphate
• 英文别名: sodium;[2-(9-fluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl)-2-oxoethyl] dihydrogen phosphate
• CAS: 151-73-5
• 化学式: C22H30FNaO8P+
• 分子量: 495.4
• InChiKey: MQRFYYBWKRACSJ-UHFFFAOYSA-N

物化性质

• 熔点：
  206-211°C
• 比旋光度：
  +98.0～+104.0°(D/20℃)(c=1,H2O) (calculated on the dehydrous basis)
• 溶解度：
  易溶于水，微溶于乙醇（96%），几乎不溶于二氯甲烷。

计算性质

• 辛醇/水分配系数(LogP)：
  -0.98
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  141
• 氢给体数：
  4
• 氢受体数：
  9

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S36
• 危险类别码：
  R22
• WGK Germany：
  3
• 海关编码：
  2937229000
• RTECS号：
  TU4056500

SDS

Betamethasone 21-Phosphate Disodium Salt
SAFETY DATA SHEET

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Section 1. IDENTIFICATION
Product name: Betamethasone 21-Phosphate Disodium Salt
5.3

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Section 2. HAZARDS IDENTIFICATION
GHS classification
PHYSICAL HAZARDS Not classified
HEALTH HAZARDS
Acute toxicity (Oral) Category 4
Not classified
ENVIRONMENTAL HAZARDS
GHS label elements, including precautionary statements
Pictograms or hazard symbols
Signal word Warning
Hazard statements Harmful if swallowed
Precautionary statements:
[Prevention] Do not eat, drink or smoke when using this product.
Wash hands thoroughly after handling.
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
[Response]
Rinse mouth.
Dispose of contents/container through a waste management company authorized by
[Disposal]
the local government.

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substance/mixture: Substance
Components: Betamethasone 21-Phosphate Disodium Salt
Percent: >98.0%(HPLC)(T)
CAS Number: 151-73-5
Chemical Formula: C22H28FNa2O8P

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Section 4. FIRST AID MEASURES
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Get medical advice/attention if you feel unwell.
Skin contact: Remove/Take off immediately all contaminated clothing. Rinse skin with
water/shower. If skin irritation or rash occurs: Get medical advice/attention.
Eye contact: Rinse cautiously with water for several minutes. Remove contact lenses, if present
and easy to do. Continue rinsing. If eye irritation persists: Get medical
advice/attention.

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Section 4. FIRST AID MEASURES
Ingestion: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth.
Protection of first-aiders: A rescuer should wear personal protective equipment, such as rubber gloves and air-
tight goggles.

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Section 5. FIRE-FIGHTING MEASURES
Suitable extinguishing Dry chemical, foam, water spray, carbon dioxide.
media:
Specific hazards arising Take care as it may decompose upon combustion or in high temperatures to
generate poisonous fume.
from the chemical:
Precautions for firefighters: Fire-extinguishing work is done from the windward and the suitable fire-extinguishing
method according to the surrounding situation is used. Uninvolved persons should
evacuate to a safe place. In case of fire in the surroundings: Remove movable
containers if safe to do so.
Special protective When extinguishing fire, be sure to wear personal protective equipment.
equipment for firefighters:

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Section 6. ACCIDENTAL RELEASE MEASURES
Use personal protective equipment. Keep people away from and upwind of spill/leak.
Personal precautions,
protective equipment and Entry to non-involved personnel should be controlled around the leakage area by
emergency procedures: roping off, etc.
Environmental precautions: Prevent product from entering drains.
Methods and materials for Sweep dust to collect it into an airtight container, taking care not to disperse it.
containment and cleaning Adhered or collected material should be promptly disposed of, in accordance with
up: appropriate laws and regulations.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Handling is performed in a well ventilated place. Wear suitable protective equipment.
Technical measures:
Prevent dispersion of dust. Wash hands and face thoroughly after handling.
Use a local exhaust if dust or aerosol will be generated.
Advice on safe handling: Avoid contact with skin, eyes and clothing.
Conditions for safe storage, including any
incompatibilities
Storage conditions: Keep container tightly closed. Store in a cool and dark place.
Store under inert gas.
Protect from moisture.
Store away from incompatible materials such as oxidizing agents.
Hygroscopic
Packaging material: Comply with laws.

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Section 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Engineering controls: Install a closed system or local exhaust as possible so that workers should not be
exposed directly. Also install safety shower and eye bath.
Personal protective equipment
Respiratory protection: Dust respirator. Follow local and national regulations.
Hand protection: Protective gloves.
Safety glasses. A face-shield, if the situation requires.
Eye protection:
Skin and body protection: Protective clothing. Protective boots, if the situation requires.

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Physical state (20°C): Solid
Crystal- Powder
Form:
Colour: White - Almost white
No data available
Odour:
pH: No data available
Melting point/freezing point:No data available

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Boiling point/range: No data available
Flash point: No data available
Flammability or explosive
limits:
Lower: No data available
Upper: No data available
Relative density: No data available
Solubility(ies):
[Water] Slightly soluble
No data available
[Other solvents]

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Section 10. STABILITY AND REACTIVITY
Chemical stability: Stable under proper conditions.
Possibility of hazardous No special reactivity has been reported.
reactions:
Incompatible materials: Oxidizing agents
Hazardous decomposition Carbon monoxide, Carbon dioxide, Hydrogen fluoride, Phosphorus oxides
products:

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Section 11. TOXICOLOGICAL INFORMATION
orl-rat LD50:1877 mg/kg
Acute Toxicity:
ipr-rat LD50:1179 mg/kg
ivn-rat LD50:1276 mg/kg
scu-rat LD50:1265 mg/kg
Skin corrosion/irritation: No data available
Serious eye No data available
damage/irritation:
Germ cell mutagenicity: No data available
Carcinogenicity:
IARC = No data available
NTP = No data available
Reproductive toxicity: No data available
RTECS Number: TU4056500

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Section 12. ECOLOGICAL INFORMATION
Ecotoxicity:
Fish: No data available
No data available
Crustacea:
Algae: No data available
Persistence / degradability: No data available
Bioaccumulative No data available
potential(BCF):
Mobility in soil
Log Pow: No data available
Soil adsorption (Koc): No data available
No data available
Henry's Law
constant(PaM3/mol):

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Section 13. DISPOSAL CONSIDERATIONS
Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system.
Observe all federal, state and local regulations when disposing of the substance.

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Section 14. TRANSPORT INFORMATION
Hazards Class: Does not correspond to the classification standard of the United Nations
UN-No: Not listed

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Section 15. REGULATORY INFORMATION
Safe management ordinance of dangerous chemical product (State Council announces on January 26, 2002
and revised on February 16,2011): Safe use and production, the storage of a dangerous chemical, transport,
loading and unloading were prescribed.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

概述

倍他米松磷酸钠是一种糖皮质激素类药物，具有抗免疫和抗炎作用，在临床中应用多年。作为一种长效的激素类药物，它常用于抗炎治疗、免疫性疾病治疗、抗病毒和休克治疗等。与其他糖皮质激素相比，倍他米松磷酸钠的特点是剂量小、半衰期长且效果明显。

用途

主要用于过敏性和自身免疫性疾病的治疗，如活动性风湿病、类风湿性关节炎、红斑狼疮、严重支气管炎、急性白血病等。同时，它也被用于某些危重感染的综合治疗以及局部外用治疗过敏性皮炎、湿疹、神经性皮炎、脂溢性皮炎及瘙痒症。

药物相互作用

（1）非甾体消炎镇痛药可能增强其致溃疡的作用。 （2）可增加对乙酰氨基酚的肝毒性。 （3）与两性霉素B或碳酸酐酶抑制剂合用，可能会加重低钾血症；长期与碳酸酐酶抑制剂合用，易引发低血钙和骨质疏松。 （4）与蛋白质同化激素合用时，会增加水肿的发生率及痤疮的严重程度。 （5）与抗胆碱能药（如阿托品）长期合用可能导致眼压增高。 （6）三环类抗抑郁药可加重其引起的症状。 （7）与降糖药如胰岛素合用时，会因倍他米松磷酸钠的使用而导致糖尿病患者血糖升高，需适当调整降糖药剂量。 （8）甲状腺激素可能加速倍他米松磷酸钠在体内的代谢清除率，因此与其合用应调整甲状腺激素或抗甲状腺药物的剂量。 （9）与避孕药或雌激素制剂合用时，会加强其治疗效果和不良反应。 （10）与强心苷合用可能增加洋地黄毒性及心律失常的发生风险。 （11）与排钾利尿药合用可能导致严重低血钾，并减弱利尿剂的排钠利尿作用。 （12）与麻黄碱合用时，会加速麻黄碱在体内的代谢清除。 （13）与免疫抑制剂合用可能会增加感染风险并诱发淋巴瘤或其他淋巴细胞增生性疾病。 （14）可加快异烟肼在肝脏中的代谢和排泄，降低其血药浓度及疗效。 （15）促进美西律在体内的代谢，导致其血药浓度下降。 （16）与水杨酸盐合用时会减少血液中水杨酸盐的浓度。 （17）与生长激素合用会抑制后者促生长作用。

其他信息

• 激素类药物，具有抗炎作用。
• 类别：有毒物品
• 毒性分级：中毒
• 急性毒性：
  • 口服-大鼠 LD50: 1877毫克/公斤
  • 口服-小鼠 LD50: 1607毫克/公斤
• 可燃性危险特性：可燃；燃烧会产生有毒的氟化物、磷氧化物和氧化钠烟雾。
• 储运特性：通风低温干燥。
• 灭火剂：干粉、泡沫、沙土、二氧化碳及雾状水。