(1R,4aR,7S,8aS,10aS)-1,4a,7-Trimethyl-7-(2-oxo-ethyl)-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodecahydro-phenanthrene-1-carboxylic acid 2-trimethylsilanyl-ethyl ester | 233750-28-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (1R,4aR,7S,8aS,10aS)-1,4a,7-Trimethyl-7-(2-oxo-ethyl)-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodecahydro-phenanthrene-1-carboxylic acid 2-trimethylsilanyl-ethyl ester
• CAS: 233750-28-2
• 化学式: C₂₅H₄₂O₃Si
• 分子量: 418.692
• InChiKey: AKIULRVLOWGBLT-FXHPDJDUSA-N

反应信息

• 作为反应物：
  描述：

  (1R,4aR,7S,8aS,10aS)-1,4a,7-Trimethyl-7-(2-oxo-ethyl)-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodecahydro-phenanthrene-1-carboxylic acid 2-trimethylsilanyl-ethyl ester 在 4,4'-二氨基二苯乙烯-2,2'-二磺酸 作用下， 以 二氯甲烷 为溶剂， 生成 (1R,4aR,7S,8aS,10aS)-7-(2,2-Difluoro-ethyl)-1,4a,7-trimethyl-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodecahydro-phenanthrene-1-carboxylic acid 2-trimethylsilanyl-ethyl ester
  参考文献：
  名称：

  Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure–activity relationship

  摘要：

  The structure-activity relationship and molecular modelings of a novel pimarane COX-2 inhibitor are reported. Particularly, a series of linker extended analogues designed on the basis of these studies exhibited significantly enhanced COX-2 inhibitory activities and selectivities. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00004-x
• 作为产物：
  描述：

  (1R,4aR,7S,8aS,10aS)-7-(2-Hydroxy-ethyl)-1,4a,7-trimethyl-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodecahydro-phenanthrene-1-carboxylic acid 2-trimethylsilanyl-ethyl ester 在 N-甲基吲哚酮 、 四丙基高钌酸铵 作用下， 以 二氯甲烷 为溶剂， 生成 (1R,4aR,7S,8aS,10aS)-1,4a,7-Trimethyl-7-(2-oxo-ethyl)-1,2,3,4,4a,6,7,8,8a,9,10,10a-dodecahydro-phenanthrene-1-carboxylic acid 2-trimethylsilanyl-ethyl ester
  参考文献：
  名称：

  Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure–activity relationship

  摘要：

  The structure-activity relationship and molecular modelings of a novel pimarane COX-2 inhibitor are reported. Particularly, a series of linker extended analogues designed on the basis of these studies exhibited significantly enhanced COX-2 inhibitory activities and selectivities. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00004-x