2-(p-trifluoroacetamidophenyl)ethyl (5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->3)-(2-O-acetyl-β-D-galactopyranosyl)-(1->4)-β-D-glucopyranoside | 357674-81-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(p-trifluoroacetamidophenyl)ethyl (5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->3)-(2-O-acetyl-β-D-galactopyranosyl)-(1->4)-β-D-glucopyranoside
• CAS: 357674-81-8
• 化学式: C₄₃H₅₇F₃N₂O₂₅
• 分子量: 1058.92
• InChiKey: DPKBHHWTRLAFQK-SFJJMQBLSA-N

反应信息

• 作为反应物：
  描述：

  2-(p-trifluoroacetamidophenyl)ethyl (5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->3)-(2-O-acetyl-β-D-galactopyranosyl)-(1->4)-β-D-glucopyranoside 在 甲醇 、 ammonium hydroxide 、 sodium 作用下， 生成 2-(p-aminophenyl)ethyl (5-acetamido-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->3)-(β-D-galactopyranosyl)-(1->4)-β-D-glucopyranoside
  参考文献：
  名称：

  CYCLODEXTRIN—A CARRIER OR SYNTHON? SYNTHESIS OF PER-O-METHYL-β- CYCLODEXTRIN-GM₃

  摘要：

  Cyclodextrins are currently under investigation for their utility as drug delivery agents. One property of the parent cyclic oligosaccharides which requires further modification for advanced drug delivery applications is that of site-directing capability. We have utilized beta -cyclodextrin as a starting material for the synthesis of the GM(3) trisaccharide and have conjugated this targeting ligand to a derivative of the parent beta -cyclodextrin. Synthesis of this cyclodextrin derivative, namely 18, is presented.

  DOI：

  10.1081/car-100102540
• 作为产物：
  描述：

  2-(p-trifluoroacetamidophenyl)ethyl (benzyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonate)-(2->3)-(2-O-acetyl-4,6-O-benzylidene-β-D-galactopyranosyl)-(1->4)-2,3,6-tri-O-benzyl-β-D-glucopyranoside 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 20.0 ℃ 、34.47 kPa 条件下， 反应 20.0h， 以538 mg的产率得到2-(p-trifluoroacetamidophenyl)ethyl (5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->3)-(2-O-acetyl-β-D-galactopyranosyl)-(1->4)-β-D-glucopyranoside
  参考文献：
  名称：

  CYCLODEXTRIN—A CARRIER OR SYNTHON? SYNTHESIS OF PER-O-METHYL-β- CYCLODEXTRIN-GM₃

  摘要：

  Cyclodextrins are currently under investigation for their utility as drug delivery agents. One property of the parent cyclic oligosaccharides which requires further modification for advanced drug delivery applications is that of site-directing capability. We have utilized beta -cyclodextrin as a starting material for the synthesis of the GM(3) trisaccharide and have conjugated this targeting ligand to a derivative of the parent beta -cyclodextrin. Synthesis of this cyclodextrin derivative, namely 18, is presented.

  DOI：

  10.1081/car-100102540