| 1092375-94-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1092375-94-4
• 化学式: C₁₃H₂₄ClN₃O
• 分子量: 273.806
• InChiKey: RHKVMWVKONPLQT-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 potassium fluoride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.08h， 生成
  参考文献：
  名称：

  Chemical probes for profiling fatty acid-associated proteins in living cells

  摘要：

  Chemical probes appended with reactive electrophiles afford powerful tools for pro. ling discrete protein families in living cells. Herein, we have synthesized cell-permeable chemical probes that target fatty acid-associated proteins. These fatty acid-based chemical probes contain acyloxymethylketone or fluorophosphonate functional groups and an alkyne click chemistry tag for visualization of covalently modified proteins by in-gel fluorescence scanning. Our fatty acid-based chemical probe affords new tools to evaluate the activity/expression of lipid-associated proteins that should facilitate their functional characterization and inhibitor discovery. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2008.09.083
• 作为产物：
  描述：

  在 盐酸 、 溶剂黄146 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 0.17h， 生成
  参考文献：
  名称：

  Chemical probes for profiling fatty acid-associated proteins in living cells

  摘要：

  Chemical probes appended with reactive electrophiles afford powerful tools for pro. ling discrete protein families in living cells. Herein, we have synthesized cell-permeable chemical probes that target fatty acid-associated proteins. These fatty acid-based chemical probes contain acyloxymethylketone or fluorophosphonate functional groups and an alkyne click chemistry tag for visualization of covalently modified proteins by in-gel fluorescence scanning. Our fatty acid-based chemical probe affords new tools to evaluate the activity/expression of lipid-associated proteins that should facilitate their functional characterization and inhibitor discovery. Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2008.09.083