(2RS,4R,5S)-2-(4-methoxyphenyl)-5-methyl-4((S)-methylallyl)-[1,3]dioxane | 1044739-28-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (2RS,4R,5S)-2-(4-methoxyphenyl)-5-methyl-4((S)-methylallyl)-[1,3]dioxane
• CAS: 1044739-28-7
• 化学式: C₁₆H₂₂O₃
• 分子量: 262.349
• InChiKey: IOLDUKGVLUKDSI-LQGTWBQSSA-N

反应信息

• 作为产物：
  描述：

  (2S)-1-(4-methoxybenzyloxy)-2,4-dimethylhex-5-en-3-ol 在 4 A molecular sieve 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 (2RS,4R,5S)-2-(4-methoxyphenyl)-5-methyl-4((S)-methylallyl)-[1,3]dioxane 、 (2RS,4S,5S)-2-(4-methoxyphenyl)-5-methyl-4((R)-methylallyl)-[1,3]dioxane
  参考文献：
  名称：

  Synthetic studies toward cytostatin, a natural product inhibitor of protein phosphatase 2A

  摘要：

  Synthetic approaches toward the natural product cytostatin, an inhibitor of protein phosphatase 2A possessing cytotoxic and antimetastatic activities, have been investigated. A formal synthesis of cytostatin has been achieved according to a strategy relying on the formation of the C8-C9 bond by a nucleophilic addition of a functionalized organolithium (C1-C8 subunit) to an aldehyde (C9-C13 subunit). (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.05.012