3,6-anhydro-4,5,7-tri-O-benzyl-2-deoxy-3-C-(aminomethyl(N-tert-butoxycarbonyl))-D-manno-heptonic acid lactol | 1046152-98-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,6-anhydro-4,5,7-tri-O-benzyl-2-deoxy-3-C-(aminomethyl(N-tert-butoxycarbonyl))-D-manno-heptonic acid lactol
• CAS: 1046152-98-0
• 化学式: C₃₄H₄₁NO₇
• 分子量: 575.702
• InChiKey: KOVWQDPKBGLTDZ-QGMZYPOXSA-N

反应信息

• 作为反应物：
  描述：

  3,6-anhydro-4,5,7-tri-O-benzyl-2-deoxy-3-C-(aminomethyl(N-tert-butoxycarbonyl))-D-manno-heptonic acid lactol 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以78%的产率得到3,6-anhydro-4,5,7-tri-O-benzyl-2-deoxy-3-C-(aminomethyl(N-tert-butoxycarbonyl))-D-manno-heptonic acid lactam
  参考文献：
  名称：

  Fructose-fused γ-butyrolactones and lactams, synthesis and biological evaluation as GABA receptor ligands

  摘要：

  We describe the synthesis of sugar-fused beta-disubstituted gamma-butyrolactones, gamma-butyrolactams and a lipophilic beta-disubstituted GABA analogue as potential GABA receptor ligands, where the pharmacophore is engineered into the carbohydrate scaffold in the form of a C-fructoside. The products were characterized for receptor binding studies of GABA(A) receptors. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2008.03.013
• 作为产物：
  描述：

  在 sodium periodate 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 3,6-anhydro-4,5,7-tri-O-benzyl-2-deoxy-3-C-(aminomethyl(N-tert-butoxycarbonyl))-D-manno-heptonic acid lactol
  参考文献：
  名称：

  Fructose-fused γ-butyrolactones and lactams, synthesis and biological evaluation as GABA receptor ligands

  摘要：

  We describe the synthesis of sugar-fused beta-disubstituted gamma-butyrolactones, gamma-butyrolactams and a lipophilic beta-disubstituted GABA analogue as potential GABA receptor ligands, where the pharmacophore is engineered into the carbohydrate scaffold in the form of a C-fructoside. The products were characterized for receptor binding studies of GABA(A) receptors. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2008.03.013