| 1017540-59-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1017540-59-8
• 化学式: C₁₂H₂₂N₄
• 分子量: 222.333
• InChiKey: ATPJXLFEIQQRBI-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 BOC-D-4-氟苯丙氨酸 在 N-甲基吗啉 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以84%的产率得到
  参考文献：
  名称：

  Synthesis and biological activity of novel peptide mimetics as melanocortin receptor agonists

  摘要：

  A series of novel peptidomimetic analogs was prepared containing cyclohexyl, phenyl, or heterocyclic groups to ostensibly orient the guanidine or mimic of an arginine in a putative melanocortin receptor ligand pharmacophore. Some binding affinity at the melanocortin receptors MC3 and MC4 was noted. In silico docking also indicated that the relative positions of the hydrogen-bonding sites and hydrophobic regions of the compounds are reasonably well matched to the receptor-binding site. This may present a lead entry into a selective series Of MC4R agonists. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.109
• 作为产物：
  描述：

  在 镍 ammonium hydroxide 、 氢气 作用下， 以 甲醇 为溶剂， 反应 4.0h， 以98%的产率得到
  参考文献：
  名称：

  Synthesis and biological activity of novel peptide mimetics as melanocortin receptor agonists

  摘要：

  A series of novel peptidomimetic analogs was prepared containing cyclohexyl, phenyl, or heterocyclic groups to ostensibly orient the guanidine or mimic of an arginine in a putative melanocortin receptor ligand pharmacophore. Some binding affinity at the melanocortin receptors MC3 and MC4 was noted. In silico docking also indicated that the relative positions of the hydrogen-bonding sites and hydrophobic regions of the compounds are reasonably well matched to the receptor-binding site. This may present a lead entry into a selective series Of MC4R agonists. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.109