[7-(1,3-dioxan-2-yl)heptyl] 2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-2-acetamido-2-deoxy-β-D-glucopyranoside | 1556777-05-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [7-(1,3-dioxan-2-yl)heptyl] 2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-2-acetamido-2-deoxy-β-D-glucopyranoside
• CAS: 1556777-05-9
• 化学式: C₄₃H₇₄N₄O₂₃
• 分子量: 1015.07
• InChiKey: JTHNJHWZZBPTPL-MQZNTHGISA-N

反应信息

• 作为反应物：
  描述：

  [7-(1,3-dioxan-2-yl)heptyl] 2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-2-acetamido-2-deoxy-β-D-glucopyranoside 在 溶剂黄146 作用下， 以 水 为溶剂， 反应 24.0h， 生成
  参考文献：
  名称：

  Preparation of synthetic oligosaccharide-conjugates of poly-β-(1→6)-N-acetyl glucosamine

  摘要：

  Staphylococcus aureus and Staphylococcus epidermidis are prominent bacterial pathogens of nosocomial infections. Both microorganisms colonize medical devices by forming adherent biofilms. poly-beta-(1 -> 6)-N-acetyl-glucosamine (PNAG) is a surface polysaccharide antigen which was found on both S. aureus and S. epidermidis. Animal studies have proved that PNAG can elicit antibodies which protect against staphylococcal infections. We have presented the synthesis of di-, tetra-and hexasaccharide fragments of PNAG with formyl-heptyl aglycone and their attachment to bovine serum albumin (BSA) by reductive amination. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2013.12.022
• 作为产物：
  描述：

  [7-(1,3-dioxan-2-yl)heptyl] 3,4,6-tri-O-acetyl-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-3,4-di-O-acetyl-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-3,4-di-O-acetyl-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-3,4-di-O-acetyl-2-acetamido-2-deoxy-β-D-glucopyranoside 在 甲醇 、 sodium methylate 作用下， 反应 24.0h， 以84%的产率得到[7-(1,3-dioxan-2-yl)heptyl] 2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-2-acetamido-2-deoxy-β-D-glucopyranosyl-(1→6)-2-acetamido-2-deoxy-β-D-glucopyranoside
  参考文献：
  名称：

  Preparation of synthetic oligosaccharide-conjugates of poly-β-(1→6)-N-acetyl glucosamine

  摘要：

  Staphylococcus aureus and Staphylococcus epidermidis are prominent bacterial pathogens of nosocomial infections. Both microorganisms colonize medical devices by forming adherent biofilms. poly-beta-(1 -> 6)-N-acetyl-glucosamine (PNAG) is a surface polysaccharide antigen which was found on both S. aureus and S. epidermidis. Animal studies have proved that PNAG can elicit antibodies which protect against staphylococcal infections. We have presented the synthesis of di-, tetra-and hexasaccharide fragments of PNAG with formyl-heptyl aglycone and their attachment to bovine serum albumin (BSA) by reductive amination. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2013.12.022