tert-butyl (Z)-2-[amino(phenyl)methylene]-3-oxobutanoate | 1629803-11-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: tert-butyl (Z)-2-[amino(phenyl)methylene]-3-oxobutanoate
• CAS: 1629803-11-7
• 化学式: C₁₅H₁₉NO₃
• 分子量: 261.321
• InChiKey: YEHTXVATAOHCOH-SEYXRHQNSA-N

反应信息

• 作为反应物：
  描述：

  tert-butyl (Z)-2-[amino(phenyl)methylene]-3-oxobutanoate 在 (二氯碘)-苯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.42h， 以79%的产率得到tert-butyl (E)-2-chloro-2-[(chloroimino)(phenyl)methyl]-3-oxobutanoate
  参考文献：
  名称：

  PhICl2-Mediated Conversion of Enamines into α,N-Dichloroimines and Their Reverse Conversion Mediated by Zinc in Methanol

  摘要：

  Treatment of enamine compounds with iodobenzene dichloride (PhICl2) conveniently gives a variety of alpha,N-dichloroimines in high yields. This approach allows the double insertion of the chloro moiety, which is postulated to take place via the iodobenzene dichloride mediated oxidative alpha-chlorination of the enamine substrates followed by further N-chlorination of the imine intermediates. Furthermore, the obtained alpha,N-dichloroimines could be converted reversely into the original enamines under reductive conditions using zinc in methanol.

  DOI：

  10.1055/s-0033-1341067
• 作为产物：
  描述：

  tert-butyl (E)-2-chloro-2-[(chloroimino)(phenyl)methyl]-3-oxobutanoate 在 锌 作用下， 以 甲醇 为溶剂， 以73%的产率得到tert-butyl (Z)-2-[amino(phenyl)methylene]-3-oxobutanoate
  参考文献：
  名称：

  PhICl2-Mediated Conversion of Enamines into α,N-Dichloroimines and Their Reverse Conversion Mediated by Zinc in Methanol

  摘要：

  Treatment of enamine compounds with iodobenzene dichloride (PhICl2) conveniently gives a variety of alpha,N-dichloroimines in high yields. This approach allows the double insertion of the chloro moiety, which is postulated to take place via the iodobenzene dichloride mediated oxidative alpha-chlorination of the enamine substrates followed by further N-chlorination of the imine intermediates. Furthermore, the obtained alpha,N-dichloroimines could be converted reversely into the original enamines under reductive conditions using zinc in methanol.

  DOI：

  10.1055/s-0033-1341067