6(R)-<2-<1,2,3,4,6,7,8,8a(R)-Octahydro-2(R),6(R)-dimethyl-8(S)-<<2(S)-methylbutyryl>oxy>-3(R)-acetoxy-1(S)-naphthyl>ethyl>-3,4,5,6-tetrahydro-4(R)-<(tert-butyldimethylsilyl)oxy>-2H-pyran-2-one | 85614-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 6(R)-<2-<1,2,3,4,6,7,8,8a(R)-Octahydro-2(R),6(R)-dimethyl-8(S)-<<2(S)-methylbutyryl>oxy>-3(R)-acetoxy-1(S)-naphthyl>ethyl>-3,4,5,6-tetrahydro-4(R)-<(tert-butyldimethylsilyl)oxy>-2H-pyran-2-one
• CAS: 85614-10-4
• 化学式: C₃₂H₅₄O₇Si
• 分子量: 578.862
• InChiKey: VFZVHHASMLMUSG-SOOIZVGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.99
• 重原子数：
  40.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  88.13
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  乙酸酐 、 6(R)-(2-(1,2,3,4,6,7,8,8a(R)-Octahydro-2(R),6(R)-dimethyl-8(S)-((2(S)-methylbutyryl)oxy)-3(S),4(R)-dihydroxy-1(S)-naphthyl)ethyl)-3,4,5,6-tetrahydro-4(R)-((tert-butyldimethylsilyl)oxy)-2H-pyran-2-one 在 palladium on activated charcoal 氢气 作用下， 生成 6(R)-<2-<1,2,3,4,6,7,8,8a(R)-Octahydro-2(R),6(R)-dimethyl-8(S)-<<2(S)-methylbutyryl>oxy>-3(R)-acetoxy-1(S)-naphthyl>ethyl>-3,4,5,6-tetrahydro-4(R)-<(tert-butyldimethylsilyl)oxy>-2H-pyran-2-one 、 (S)-2-Methyl-butyric acid (1S,3S,6S,7R,8S,8aR)-6-acetoxy-8-{2-[(2R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-1,2,3,4,6,7,8,8a-octahydro-naphthalen-1-yl ester
  参考文献：
  名称：

  Reductive transformation and cyclopropanation of mevinolin (6.alpha.-methylcompactin). Generation of chirality in the 1,4-hydrostannation of a cyclic diene

  摘要：

  DOI：

  10.1021/jo00160a010