| 1558058-18-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1558058-18-6
• 化学式: C₇₈H₆₈NO₁₉PS
• 分子量: 1386.43
• InChiKey: DTPNCFGMRNBNPB-GXZPMOFRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.21
• 重原子数：
  100.0
• 可旋转键数：
  26.0
• 环数：
  12.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  242.28
• 氢给体数：
  1.0
• 氢受体数：
  21.0

反应信息

• 作为反应物：
  描述：

  在 吡啶 、 1,2,3,4,5,6,7,8-八硫杂环辛烷 作用下， 以 二硫化碳 为溶剂， 反应 0.5h， 生成 (2R,3R,4S,5S,6R)-2-((benzoyloxy)methyl)-6-((((R)-phenyl((S)-pyrrolidin-2-yl)methoxy)(((2R,3R,4S,5R,6S)-3,4,5-tris(benzoyloxy)-6-(phenylthio)tetrahydro-2H-pyran-2-yl)methoxy)phosphorothioyl)oxy)tetrahydro-2H-pyran-3,4,5-triyl tribenzoate
  参考文献：
  名称：

  Stereoselective Synthesis of P-Modified α-Glycosyl Phosphates by the Oxazaphospholidine Approach

  摘要：

  alpha-Glycosyl phosphate derivatives are widely known as constituents of biomolecules. To date, several types of non-natural alpha-glycosyl phosphates including "P-modified analogs" have been synthesized to investigate their characteristics. Herein a new approach to the stereoselective modification of the intersugar phosphorus atom in alpha-glycosyl phosphates by use of the oxazaphospholidine method is presented. Via this approach, the dimers of alpha-glycosyl phosphorothioates and alpha-glycosyl boranophosphates were obtained efficiently and stereoselectively.

  DOI：

  10.1021/ol402785h
• 作为产物：
  描述：

  在 2,6-二甲基吡啶 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Stereoselective Synthesis of P-Modified α-Glycosyl Phosphates by the Oxazaphospholidine Approach

  摘要：

  alpha-Glycosyl phosphate derivatives are widely known as constituents of biomolecules. To date, several types of non-natural alpha-glycosyl phosphates including "P-modified analogs" have been synthesized to investigate their characteristics. Herein a new approach to the stereoselective modification of the intersugar phosphorus atom in alpha-glycosyl phosphates by use of the oxazaphospholidine method is presented. Via this approach, the dimers of alpha-glycosyl phosphorothioates and alpha-glycosyl boranophosphates were obtained efficiently and stereoselectively.

  DOI：

  10.1021/ol402785h