(2S,3R,4R,5R)-4-Benzyloxy-5-dodecyl-tetrahydro-furan-2,3-diol | 213455-70-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3R,4R,5R)-4-Benzyloxy-5-dodecyl-tetrahydro-furan-2,3-diol
• CAS: 213455-70-0
• 化学式: C₂₃H₃₈O₄
• 分子量: 378.552
• InChiKey: WVBXJJIQUCKWGU-LUKWVAJMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.96
• 重原子数：
  27.0
• 可旋转键数：
  14.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  58.92
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (2S,3R,4R,5R)-4-Benzyloxy-5-dodecyl-tetrahydro-furan-2,3-diol 在 palladium on activated charcoal sodium periodate 、 氢气 、 sodium hydride 、 三氟乙酸 作用下， 以 甲醇 、 水 、 乙酸乙酯 为溶剂， 反应 31.5h， 生成 (5R)-5-[(1R)-1-羟基十三烷基]四氢呋喃-2-酮
  参考文献：
  名称：

  Syntheses and Cytotoxicities of Four Stereoisomers of Muricatacin from d -Glucose

  摘要：

  Four stereoisomers of muricatacin 1a-d were prepared by the reaction of corresponding aldehydes 4a-d, which in turn were prepared from D-glucose, with the anion of triethylphosphonoacetate followed by reduction and cyclization under acidic conditions. Cytotoxicities of four stereoisomers were tested against in vitro A-549 cell line as well as MCF-7 cell line. Stereochemistry at C-4 and C-5 position of muricatacin did not affect the cytotoxicities significantly. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00062-5
• 作为产物：
  描述：

  (3aR,5R,6S,6aR)-6-Benzyloxy-5-dodecyl-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole 在 盐酸 作用下， 以 乙二醇二甲醚 为溶剂， 反应 48.0h， 以67%的产率得到(2S,3R,4R,5R)-4-Benzyloxy-5-dodecyl-tetrahydro-furan-2,3-diol
  参考文献：
  名称：

  Syntheses and Cytotoxicities of Four Stereoisomers of Muricatacin from d -Glucose

  摘要：

  Four stereoisomers of muricatacin 1a-d were prepared by the reaction of corresponding aldehydes 4a-d, which in turn were prepared from D-glucose, with the anion of triethylphosphonoacetate followed by reduction and cyclization under acidic conditions. Cytotoxicities of four stereoisomers were tested against in vitro A-549 cell line as well as MCF-7 cell line. Stereochemistry at C-4 and C-5 position of muricatacin did not affect the cytotoxicities significantly. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(98)00062-5