2,2,2-Trichloro-acetimidic acid (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39,43-undecamethyl-tetratetraconta-2,6,10,14,18,22,26,30,34,38,42-undecaenyl ester | 932014-78-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2,2,2-Trichloro-acetimidic acid (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39,43-undecamethyl-tetratetraconta-2,6,10,14,18,22,26,30,34,38,42-undecaenyl ester
• CAS: 932014-78-3
• 化学式: C₅₇H₉₀Cl₃NO
• 分子量: 911.707
• InChiKey: NYDYUVNEJUACGA-RUCFZNOGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  20.58
• 重原子数：
  62.0
• 可旋转键数：
  32.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  33.08
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  2,2,2-Trichloro-acetimidic acid (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39,43-undecamethyl-tetratetraconta-2,6,10,14,18,22,26,30,34,38,42-undecaenyl ester 在 哌啶 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 0.33h， 生成 Phosphoric acid 2-amino-ethyl ester (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39,43-undecamethyl-tetratetraconta-2,6,10,14,18,22,26,30,34,38,42-undecaenyl ester
  参考文献：
  名称：

  Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates

  摘要：

  In order to investigate the transmembrane movement of polyprenyl phosphate across biological membranes, NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled polyprenyl phosphate analogues were prepared. These analogues proved to be possible tools for a direct observation of the transmembrane flip-flop movement of polyprenyl phosphates by use of a sodium dithionitequenching procedure. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.11.049
• 作为产物：
  描述：

  ficaprenol-11 、 三氯乙腈 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 反应 9.0h， 以85%的产率得到2,2,2-Trichloro-acetimidic acid (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-3,7,11,15,19,23,27,31,35,39,43-undecamethyl-tetratetraconta-2,6,10,14,18,22,26,30,34,38,42-undecaenyl ester
  参考文献：
  名称：

  Novel fluorescent analogues for transmembrane movement study of polyprenyl phosphates

  摘要：

  In order to investigate the transmembrane movement of polyprenyl phosphate across biological membranes, NBD (7-nitrobenz-2-oxa-1,3-diazol-4-yl)-labeled polyprenyl phosphate analogues were prepared. These analogues proved to be possible tools for a direct observation of the transmembrane flip-flop movement of polyprenyl phosphates by use of a sodium dithionitequenching procedure. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.11.049

文献信息

• Phosphorylation of Polyprenols via Their Trichloroacetimidates
  作者：Leonid L. Danilov、Vladimir N. Shibaev、Nikolai K. Kochetkov

  DOI：10.1055/s-1984-30853

  日期：——