Methanesulfonic acid (4R,5R)-2,2-diethyl-5-methanesulfonyloxymethyl-[1,3]dioxolan-4-ylmethyl ester | 146092-14-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methanesulfonic acid (4R,5R)-2,2-diethyl-5-methanesulfonyloxymethyl-[1,3]dioxolan-4-ylmethyl ester
• 英文别名: [(4R,5R)-2,2-diethyl-5-(methylsulfonyloxymethyl)-1,3-dioxolan-4-yl]methyl methanesulfonate
• CAS: 146092-14-0
• 化学式: C₁₁H₂₂O₈S₂
• 分子量: 346.423
• InChiKey: VNOFVKYILVSHSL-NXEZZACHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  122
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Methanesulfonic acid (4R,5R)-2,2-diethyl-5-methanesulfonyloxymethyl-[1,3]dioxolan-4-ylmethyl ester 在 palladium on activated charcoal sodium azide 、 氢气 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 40.0~100.0 ℃ 、344.73 kPa 条件下， 反应 18.0h， 生成 (4R,5R)-4,5-bis(aminomethyl)-2,2-diethyl-1,3-dioxolane
  参考文献：
  名称：

  Synthesis and in vitro cytotoxicity of cis-(glycolato-O,O′)-[2-substituted-(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane]platinum (II)

  摘要：

  The synthesis and in vitro cyto toxicity of cis-(glycolato-O,O')[2-substituted-(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane]platinum(II) are described. Among them, cis-(glycolato-O,O') [(4R,5R)-4,5-bis (aminomethyl)-2,2-diethyl-1,3-dioxolane] platinum(II) (26) was found to be almost equally cytotoxic to cisplatin against two human non-small cell lung cancer cell lines, PC-9 and PC-14, and two human stomach cancer cell lines, MKN-45 and KATO III. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00126-6
• 作为产物：
  描述：

  (2R,3R)-1,4-二(甲磺酰基氧基)丁烷-2,3-二醇 、 3-戊酮 在 甲烷磺酸 、 potassium carbonate 、 copper(II) sulfate 作用下， 生成 Methanesulfonic acid (4R,5R)-2,2-diethyl-5-methanesulfonyloxymethyl-[1,3]dioxolan-4-ylmethyl ester
  参考文献：
  名称：

  Synthesis and in vitro cytotoxicity of cis-(glycolato-O,O′)-[2-substituted-(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane]platinum (II)

  摘要：

  The synthesis and in vitro cyto toxicity of cis-(glycolato-O,O')[2-substituted-(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane]platinum(II) are described. Among them, cis-(glycolato-O,O') [(4R,5R)-4,5-bis (aminomethyl)-2,2-diethyl-1,3-dioxolane] platinum(II) (26) was found to be almost equally cytotoxic to cisplatin against two human non-small cell lung cancer cell lines, PC-9 and PC-14, and two human stomach cancer cell lines, MKN-45 and KATO III. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00126-6

文献信息

• NOVEL PLATINUM(II) COMPLEX AND PROCESSES FOR PREPARING THE SAME
  申请人：SUNKYONG INDUSTRIES LTD.

  公开号：EP0586378B1

  公开（公告）日：1998-09-23