1-[2-(2-{1-Bromomethyl-2-[2-(2-hexadecyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-hexadecane | 255906-36-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2-(2-{1-Bromomethyl-2-[2-(2-hexadecyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-hexadecane
• 英文别名: 1-[2-[2-[3-Bromo-2-[2-(2-hexadecoxyethoxy)ethoxy]propoxy]ethoxy]ethoxy]hexadecane；1-[2-[2-[3-bromo-2-[2-(2-hexadecoxyethoxy)ethoxy]propoxy]ethoxy]ethoxy]hexadecane
• CAS: 255906-36-6
• 化学式: C₄₃H₈₇BrO₆
• 分子量: 780.064
• InChiKey: UOCKRNKXRKJMAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.7
• 重原子数：
  50
• 可旋转键数：
  46
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-[2-(2-{1-Bromomethyl-2-[2-(2-hexadecyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-hexadecane 、 三甲胺 以 甲苯 、 乙腈 为溶剂， 反应 24.0h， 以68%的产率得到{2,3-Bis-[2-(2-hexadecyloxy-ethoxy)-ethoxy]-propyl}-trimethyl-ammonium; bromide
  参考文献：
  名称：

  Synthesis of novel cationic lipids with oxyethylene spacers at the linkages between hydrocarbon chains and pseudoglyceryl backbone

  摘要：

  Four novel cationic lipids with oligo-oxyethylene units at various linkage regions between the pseudoglyceryl backbone and the hydrocarbon chains have been synthesized. The membrane-forming properties of these new lipids are briefly presented. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01683-4
• 作为产物：
  描述：

  二乙二醇单十六醚 在 palladium on activated charcoal 吡啶 、 氢气 、 sodium hydride 、 lithium bromide 作用下， 以 甲醇 、 二氯甲烷 、 乙酸乙酯 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 69.0h， 生成 1-[2-(2-{1-Bromomethyl-2-[2-(2-hexadecyloxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-hexadecane
  参考文献：
  名称：

  Synthesis of novel cationic lipids with oxyethylene spacers at the linkages between hydrocarbon chains and pseudoglyceryl backbone

  摘要：

  Four novel cationic lipids with oligo-oxyethylene units at various linkage regions between the pseudoglyceryl backbone and the hydrocarbon chains have been synthesized. The membrane-forming properties of these new lipids are briefly presented. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01683-4

文献信息

• Synthesis of novel cationic lipids with oxyethylene spacers at the linkages between hydrocarbon chains and pseudoglyceryl backbone
  作者：Santanu Bhattacharya、P.V. Dileep

  DOI：10.1016/s0040-4039(99)01683-4

  日期：1999.11

  Four novel cationic lipids with oligo-oxyethylene units at various linkage regions between the pseudoglyceryl backbone and the hydrocarbon chains have been synthesized. The membrane-forming properties of these new lipids are briefly presented. (C) 1999 Elsevier Science Ltd. All rights reserved.