2-Bromo-2-pyridin-4-yl-1-(4-triisopropylsilanyloxy-phenyl)-ethanone | 412051-36-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Bromo-2-pyridin-4-yl-1-(4-triisopropylsilanyloxy-phenyl)-ethanone
• 英文别名: 2-Bromo-2-pyridin-4-yl-1-[4-tri(propan-2-yl)silyloxyphenyl]ethanone；2-bromo-2-pyridin-4-yl-1-[4-tri(propan-2-yl)silyloxyphenyl]ethanone
• CAS: 412051-36-6
• 化学式: C₂₂H₃₀BrNO₂Si
• 分子量: 448.475
• InChiKey: CFCHABCVJCYQEK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.95
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-Bromo-2-pyridin-4-yl-1-(4-triisopropylsilanyloxy-phenyl)-ethanone 在 三乙基硅烷 、 四丁基氟化铵 、 溶剂黄146 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs

  摘要：

  A series of 3-alkyl, 3-cycloalkyl, and 3-heteroaryl dihydrobenzoxathim analogs 1 were prepared and evaluated for estrogen/anti-estrogen activity in both in vitro and in vivo models. In general, the compounds were found to exhibit a high degree of selectivity for ERalpha over ERbeta, but were less potent than the original lead compound la in the inhibition of estradiol-driven uterine proliferation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.084
• 作为产物：
  描述：

  1-(4-羟基苯基)-2-(吡啶-4-基)乙酮 在 phenyltrimethylammonium tribromide 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 2-Bromo-2-pyridin-4-yl-1-(4-triisopropylsilanyloxy-phenyl)-ethanone
  参考文献：
  名称：

  Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs

  摘要：

  A series of 3-alkyl, 3-cycloalkyl, and 3-heteroaryl dihydrobenzoxathim analogs 1 were prepared and evaluated for estrogen/anti-estrogen activity in both in vitro and in vivo models. In general, the compounds were found to exhibit a high degree of selectivity for ERalpha over ERbeta, but were less potent than the original lead compound la in the inhibition of estradiol-driven uterine proliferation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.084

文献信息

• Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs
  作者：Helen Y. Chen、Seongkon Kim、Jane Y. Wu、Elizabeth T. Birzin、Wanda Chan、Yi Tien Yang、Johanna Dahllund、Frank DiNinno、Susan P. Rohrer、James M. Schaeffer、Milton L. Hammond

  DOI：10.1016/j.bmcl.2004.02.084

  日期：2004.5

  A series of 3-alkyl, 3-cycloalkyl, and 3-heteroaryl dihydrobenzoxathim analogs 1 were prepared and evaluated for estrogen/anti-estrogen activity in both in vitro and in vivo models. In general, the compounds were found to exhibit a high degree of selectivity for ERalpha over ERbeta, but were less potent than the original lead compound la in the inhibition of estradiol-driven uterine proliferation. (C) 2004 Elsevier Ltd. All rights reserved.