5,11,17,23-Tetrakis(1,1-dimethylethyl)-28-(1-methylethoxy)pentacyclo<19.3.1.1^3,7.1^9,13.1^15,19>octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecene-25,26,27-triol | 134225-78-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5,11,17,23-Tetrakis(1,1-dimethylethyl)-28-(1-methylethoxy)pentacyclo<19.3.1.1^3,7.1^9,13.1^15,19>octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecene-25,26,27-triol
• 英文别名: 5,11,17,23-Tetratert-butyl-28-propan-2-yloxypentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaene-25,26,27-triol
• CAS: 134225-78-8
• 化学式: C₄₇H₆₂O₄
• 分子量: 691.007
• InChiKey: FZBYIWRZGYTGFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.1
• 重原子数：
  51
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  右旋樟脑-10-磺酰氯 、 5,11,17,23-Tetrakis(1,1-dimethylethyl)-28-(1-methylethoxy)pentacyclo<19.3.1.1^3,7.1^9,13.1^15,19>octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecene-25,26,27-triol 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以81%的产率得到5,11,17,23-tetra-tert-butyl-25-isopropoxy-26-((1S)-10-camphorsulfonyloxy)-27,28-dihydroxycalix[4]arene
  参考文献：
  名称：

  Regio- and stereoselective 1(S)-camphorsulfonylation of monoalkoxycalix[4]arenes

  摘要：

  The reaction of calix[4]arene monoalkyl ethers with 1(S)-camphor-10-sulfonyl chloride yields 1,2- or 1,3-alkoxy-1(S)-camphorsulfonyloxycalixarenes depending on the nature of the base used. In the presence of triethylamine only 1,3-substituted derivatives are formed. Two diastereomers of the 1,2-substituted calixarenes with clockwise and anticlockwise arrangement of alkyl and camphorsulfonyl groups at the narrow rim are formed in the presence of sodium hydride or potassium carbonate. Due to chiral induction of the camphorsulfonyl group the 1,2-substitution is diastereoselective. The ratio of diastereomers formed is dependent on the alkyl groups at the calixarene narrow rim. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2008.05.106
• 作为产物：
  描述：

  5,11,17,23-tetra-t-butyl-25,26,27,28-tetrahydroxycalix-4-arene 在 碘代三甲硅烷 、 sodium hydride 作用下， 以 四氢呋喃 、 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 5,11,17,23-Tetrakis(1,1-dimethylethyl)-28-(1-methylethoxy)pentacyclo<19.3.1.1^3,7.1^9,13.1^15,19>octacosa-1(25),3,5,7(28),9,11,13(27),15,17,19(26),21,23-dodecene-25,26,27-triol
  参考文献：
  名称：

  杯[4]芳烃单烷基醚的一般合成

  摘要：

  通过用等量的碘代甲基甲基硅烷在CHCl 3中处理易得的-（2）或二烷基醚（3），已经开发了一种首先通用且高收率合成杯[4]芳烃单烷基醚（4）的方法。

  DOI：

  10.1016/s0040-4020(01)96132-0

文献信息

• DEVICES AND METHODS INCLUDING A PRECONCENTRATOR MATERIAL FOR DETECTION OF ANALYTES
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：US20160231267A1

  公开（公告）日：2016-08-11

  Embodiments described herein provide devices and methods for the determination of analytes. The device typically includes an absorbent material that allows for an analyte sample to be concentrated and analyzed simultaneously and within a short period of time (e.g., less than 10 seconds). Embodiments described herein can provide portable and easily operable devices for on-site, real time field monitoring with high sensitivity, selectivity, and fast response time.

  本文所描述的实施例提供了用于测定分析物的设备和方法。该设备通常包括吸收材料，使得可以同时浓缩和分析分析物样品，并在短时间内（例如少于10秒）完成。本文所描述的实施例可以提供便携式和易于操作的设备，用于现场实时监测，具有高灵敏度、选择性和快速响应时间。
• A general synthesis of calix[4]arene monoalkyl ethers
  作者：Alessandro Casnati、Arturo Arduini、Eleonora Ghidini、Andrea Pochini、Rocco Ungaro

  DOI：10.1016/s0040-4020(01)96132-0

  日期：——

  A method for the first general and high yield synthesis of calix[4]arene monoalkyl ethers (4) has been developed by treating the easily available -(2) or dialkyl ethers (3) with the equivalent amount of iodotrymethylsilane in CHCl3.

  通过用等量的碘代甲基甲基硅烷在CHCl 3中处理易得的-（2）或二烷基醚（3），已经开发了一种首先通用且高收率合成杯[4]芳烃单烷基醚（4）的方法。
• Regio- and stereoselective 1(S)-camphorsulfonylation of monoalkoxycalix[4]arenes
  作者：V.I. Boyko、A.V. Yakovenko、Yu.I. Matvieiev、O.I. Kalchenko、O.V. Shishkin、S.V. Shishkina、V.I. Kalchenko

  DOI：10.1016/j.tet.2008.05.106

  日期：2008.8

  The reaction of calix[4]arene monoalkyl ethers with 1(S)-camphor-10-sulfonyl chloride yields 1,2- or 1,3-alkoxy-1(S)-camphorsulfonyloxycalixarenes depending on the nature of the base used. In the presence of triethylamine only 1,3-substituted derivatives are formed. Two diastereomers of the 1,2-substituted calixarenes with clockwise and anticlockwise arrangement of alkyl and camphorsulfonyl groups at the narrow rim are formed in the presence of sodium hydride or potassium carbonate. Due to chiral induction of the camphorsulfonyl group the 1,2-substitution is diastereoselective. The ratio of diastereomers formed is dependent on the alkyl groups at the calixarene narrow rim. (C) 2008 Published by Elsevier Ltd.