(3S,5R)-5-[(2R,3R,4S,5R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-methoxy-3,5-dimethyl-tetrahydro-pyran-2-yl]-3-{(4S,5R,6R)-6-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-5-methyl-dihydro-furan-2-one | 123219-45-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3S,5R)-5-[(2R,3R,4S,5R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-methoxy-3,5-dimethyl-tetrahydro-pyran-2-yl]-3-{(4S,5R,6R)-6-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-5-methyl-dihydro-furan-2-one
• 英文别名: (3S,5R)-5-[(2R,3R,4S,5R,6S)-4-[tert-butyl(dimethyl)silyl]oxy-6-methoxy-3,5-dimethyloxan-2-yl]-3-[(4S,5R,6R)-6-[(2R,3R)-3-[tert-butyl(dimethyl)silyl]oxypentan-2-yl]-2,2,5-trimethyl-1,3-dioxan-4-yl]-5-methyloxolan-2-one
• CAS: 123219-45-4
• 化学式: C₃₇H₇₂O₈Si₂
• 分子量: 701.145
• InChiKey: FKFJRYHOLNNQPW-VSQZHDJOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.93
• 重原子数：
  47
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.97
• 拓扑面积：
  81.7
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  (2S,3S,4R,5R,6R,7R)-7-(tert-Butyl-dimethyl-silanyloxy)-2-{(R)-2-[(2R,3R,4S,5R,6S)-4-(tert-butyl-dimethyl-silanyloxy)-6-methoxy-3,5-dimethyl-tetrahydro-pyran-2-yl]-2-hydroxy-propyl}-3,5-dihydroxy-4,6-dimethyl-nonanoic acid methoxymethyl ester 、 2,2-二甲氧基丙烷 在 对甲苯磺酸 作用下， 以 丙酮 为溶剂， 反应 0.5h， 生成 (3S,5R)-5-[(2R,3R,4S,5R,6S)-4-(tert-Butyl-dimethyl-silanyloxy)-6-methoxy-3,5-dimethyl-tetrahydro-pyran-2-yl]-3-{(4S,5R,6R)-6-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-5-methyl-dihydro-furan-2-one
  参考文献：
  名称：

  Synthesis of macrolide antibiotics. 13. synthesis of certain derivatives of the seco-acid of erythronolide B

  摘要：

  DOI：

  10.1007/bf00953721

文献信息

• SVIRIDOV, A. F.;ERMOLENKO, M. S.;YASHUNSKIJ, D. V.;BORODKIN, V. S.;KOCHET+, IZV. AN CCCP. CEP. XIM.,(1989) N 1, S. 165-171
  作者：SVIRIDOV, A. F.、ERMOLENKO, M. S.、YASHUNSKIJ, D. V.、BORODKIN, V. S.、KOCHET+

  DOI：——

  日期：——