(6S,14S,15aR,7aR)-6,14-bis(4-hydroxy-3,5-dimethoxyphenyl)-6,8,14,16,14a,15a,6a,7a-octahydro-β-carbolino[2',3'-2,1]piperazino[4,5-b]-β-carboline-7,15-dione | 1046143-25-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (6S,14S,15aR,7aR)-6,14-bis(4-hydroxy-3,5-dimethoxyphenyl)-6,8,14,16,14a,15a,6a,7a-octahydro-β-carbolino[2',3'-2,1]piperazino[4,5-b]-β-carboline-7,15-dione
• 英文别名: (3R,14S,17R,28S)-14,28-bis(4-hydroxy-3,5-dimethoxyphenyl)-1,12,15,26-tetrazaheptacyclo[15.11.0.03,15.05,13.06,11.019,27.020,25]octacosa-5(13),6,8,10,19(27),20,22,24-octaene-2,16-dione
• CAS: 1046143-25-2
• 化学式: C₄₀H₃₆N₄O₈
• 分子量: 700.748
• InChiKey: CSHOZSCVCJFPKR-SFSFMBGESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  52
• 可旋转键数：
  6
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  150
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (6S,14S,15aR,7aR)-6,14-bis(4-hydroxy-3,5-dimethoxyphenyl)-6,8,14,16,14a,15a,6a,7a-octahydro-β-carbolino[2',3'-2,1]piperazino[4,5-b]-β-carboline-7,15-dione 、 碘甲烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 10.0h， 以57%的产率得到(6S,14S,15aR,7aR)-6,14-bis(3,4,5-trimethoxyphenyl)-6,8,14,16,14a,15a,6a,7a-octahydro-β-carbolino[2',3'-2,1]piperazino[4,5-b]-β-carboline-7,15-dione
  参考文献：
  名称：

  Synthesis of diketopiperazine-based carboline homodimers and in vitro growth inhibition of human carcinomas

  摘要：

  Starting from D-or L-tryptophan, we have synthesized and characterized six compounds 2.29-2.31a and b that belong to a class of nitrogen heterocycles: the carboline-based homodimers. Each individual homodimer features a 1,3-trans relationship on each side of the central diketopiperazine core, but differs in absolute stereochemistry and also in substitution on the 40 and 400 oxygens (-Bn, -CH(3), or -H). The in vitro cytotoxicity of the six compounds was evaluated by measuring the growth inhibition in NCI-H520 and PC-3 human carcinoma cells. Phenol 2.30a inhibited cancer cell growth approximately three times better than its enantiomer 2.30b and possessed a GI(50) comparable to the clinically used agent etoposide in both cell lines. We have concluded that both the stereochemistry imparted by L-tryptophan and the presence of hydroxy substituents at the 40 and 400 positions are necessary to generate cytotoxic properties in the homodimer class. We are now employing 2.30a as a new lead compound in our efforts to discover improved indole-based cancer chemotherapeutics. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.022
• 作为产物：
  描述：

  (6S,14S,15aR,7aR)-6,14-bis[3,5-dimethoxy-4-(phenylmethoxy)phenyl]-6,8,14,16,14a,15a,6a,7a-octahydro-β-carbolino[2',3'-2,1]piperazino[4,5-b]-β-carboline-7,15-dione 在 10% Pd/C 、 氢气 作用下， 以 四氢呋喃 、 甲醇 、 丙酮 为溶剂， 反应 0.5h， 以88%的产率得到(6S,14S,15aR,7aR)-6,14-bis(4-hydroxy-3,5-dimethoxyphenyl)-6,8,14,16,14a,15a,6a,7a-octahydro-β-carbolino[2',3'-2,1]piperazino[4,5-b]-β-carboline-7,15-dione
  参考文献：
  名称：

  Synthesis of diketopiperazine-based carboline homodimers and in vitro growth inhibition of human carcinomas

  摘要：

  Starting from D-or L-tryptophan, we have synthesized and characterized six compounds 2.29-2.31a and b that belong to a class of nitrogen heterocycles: the carboline-based homodimers. Each individual homodimer features a 1,3-trans relationship on each side of the central diketopiperazine core, but differs in absolute stereochemistry and also in substitution on the 40 and 400 oxygens (-Bn, -CH(3), or -H). The in vitro cytotoxicity of the six compounds was evaluated by measuring the growth inhibition in NCI-H520 and PC-3 human carcinoma cells. Phenol 2.30a inhibited cancer cell growth approximately three times better than its enantiomer 2.30b and possessed a GI(50) comparable to the clinically used agent etoposide in both cell lines. We have concluded that both the stereochemistry imparted by L-tryptophan and the presence of hydroxy substituents at the 40 and 400 positions are necessary to generate cytotoxic properties in the homodimer class. We are now employing 2.30a as a new lead compound in our efforts to discover improved indole-based cancer chemotherapeutics. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.05.022

文献信息

• Synthesis of diketopiperazine-based carboline homodimers and in vitro growth inhibition of human carcinomas
  作者：Amy M. Deveau、Nancy E. Costa、Elizabeth M. Joshi、Timothy L. Macdonald

  DOI：10.1016/j.bmcl.2008.05.022

  日期：2008.6

  Starting from D-or L-tryptophan, we have synthesized and characterized six compounds 2.29-2.31a and b that belong to a class of nitrogen heterocycles: the carboline-based homodimers. Each individual homodimer features a 1,3-trans relationship on each side of the central diketopiperazine core, but differs in absolute stereochemistry and also in substitution on the 40 and 400 oxygens (-Bn, -CH(3), or -H). The in vitro cytotoxicity of the six compounds was evaluated by measuring the growth inhibition in NCI-H520 and PC-3 human carcinoma cells. Phenol 2.30a inhibited cancer cell growth approximately three times better than its enantiomer 2.30b and possessed a GI(50) comparable to the clinically used agent etoposide in both cell lines. We have concluded that both the stereochemistry imparted by L-tryptophan and the presence of hydroxy substituents at the 40 and 400 positions are necessary to generate cytotoxic properties in the homodimer class. We are now employing 2.30a as a new lead compound in our efforts to discover improved indole-based cancer chemotherapeutics. (C) 2008 Elsevier Ltd. All rights reserved.