Benzoic acid (2S,4aR,6S,7R,8R,8aR)-7-azido-6-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester | 640273-58-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃二恶英
• 英文名称: Benzoic acid (2S,4aR,6S,7R,8R,8aR)-7-azido-6-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester
• 英文别名: [(2S,4aR,6S,7R,8R,8aR)-7-azido-6-[2,3-dimethylbutan-2-yl(dimethyl)silyl]oxy-2-phenyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-8-yl] benzoate
• CAS: 640273-58-1
• 化学式: C₂₈H₃₇N₃O₆Si
• 分子量: 539.704
• InChiKey: OKLNFXFSOHADDN-QXISNKTOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.39
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  77.6
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Benzoic acid (2S,4aR,6S,7R,8R,8aR)-7-azido-6-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester 在 三乙基硅烷 、 三氟甲磺酸 、 4 A molecular sieve 、 四丁基氟化铵 、 三甲基铵三氧化硫共聚物 、 溶剂黄146 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 柠檬酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 生成 Benzoic acid (2R,3R,4R,5R,6R)-3-azido-6-benzyloxymethyl-2-(2,2,2-trichloro-acetimidoyloxy)-5-(2,2,2-trifluoro-ethoxysulfonyloxy)-tetrahydro-pyran-4-yl ester
  参考文献：
  名称：

  Sulfo-Protected Hexosamine Monosaccharides:  Potentially Versatile Building Blocks for Glycosaminoglycan Synthesis

  摘要：

  [GRAPHICS]2,2,2-Trifluorodiazoethane was investigated as a reagent for sulfo group protection on hexosamine monosaccharides. The synthesis of glucosamine and galactosamine building blocks fully differentiated for glycosaminoglycan synthesis and the synthesis of glycosyl donors are described. The compatibility of trifluoroethylsulfonate under a variety of reaction conditions has also been investigated.

  DOI：

  10.1021/ol035882w
• 作为产物：
  描述：

  苯甲酰氯 、 thexyldimethylsilyl 2-azido-4,6-O-benzylidene-2-deoxy-β-D-galactopyranoside 在 吡啶 作用下， 以94%的产率得到Benzoic acid (2S,4aR,6S,7R,8R,8aR)-7-azido-6-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yl ester
  参考文献：
  名称：

  Sulfo-Protected Hexosamine Monosaccharides:  Potentially Versatile Building Blocks for Glycosaminoglycan Synthesis

  摘要：

  [GRAPHICS]2,2,2-Trifluorodiazoethane was investigated as a reagent for sulfo group protection on hexosamine monosaccharides. The synthesis of glucosamine and galactosamine building blocks fully differentiated for glycosaminoglycan synthesis and the synthesis of glycosyl donors are described. The compatibility of trifluoroethylsulfonate under a variety of reaction conditions has also been investigated.

  DOI：

  10.1021/ol035882w

文献信息

• Sulfo-Protected Hexosamine Monosaccharides:  Potentially Versatile Building Blocks for Glycosaminoglycan Synthesis
  作者：Nathalie A. Karst、Tasneem F. Islam、Robert J. Linhardt

  DOI：10.1021/ol035882w

  日期：2003.12.1

  [GRAPHICS]2,2,2-Trifluorodiazoethane was investigated as a reagent for sulfo group protection on hexosamine monosaccharides. The synthesis of glucosamine and galactosamine building blocks fully differentiated for glycosaminoglycan synthesis and the synthesis of glycosyl donors are described. The compatibility of trifluoroethylsulfonate under a variety of reaction conditions has also been investigated.