Vitamin A-saeure-n-butylester | 34362-75-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Vitamin A-saeure-n-butylester
• 英文别名: Vitamin A-saeure-butylester；[7t,9t,11t,11t]retinoic acid butyl ester；[7t,9t,11t,11t]Retinsaeure-butylester；retinyl n-butyl ether；butyl (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoate
• CAS: 34362-75-9
• 化学式: C₂₄H₃₆O₂
• 分子量: 356.549
• InChiKey: QJINGMWYMMHVCS-YVDNJGTBSA-N

物化性质

• 沸点：
  465.8±14.0 °C(Predicted)
• 密度：
  0.958±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 在 三苯基膦 作用下， 生成 Vitamin A-saeure-n-butylester
  参考文献：
  名称：

  DE1068710

  摘要：

  公开号：

文献信息

• Skin cosmetics
  申请人：Takasago International Corporation

  公开号：EP1428523A1

  公开（公告）日：2004-06-16

  Skin cosmetics which are excellent in moistness and persistency of moisture-keeping effect, show light sense of touch when used and have excellent periodical stability. In addition, there are provided skin cosmetics which do not cause stickiness after their use, are excellent in rough skin improving and preventing effects, wrinkle preventing and improving effects, dinginess improving affect and the like, and also have an effect in providing the skin with smoothness and liveliness. Also, in the case of skin cleansing compositions, they exert such effects that they can provide the skin with liveliness and moistness after washing and can effectively remove fishy and ammonia smells or the like filthy smell adhered to the hand, the skin and the like. A skin cosmetic characterized in that it contains (A) at least one substance selected from seed extracts and seed hull extracts of a plant belonging to the genus Carya of the family Juglandaceae in an amount of from 0.00005 to 2% by weight as solid matter, and (B) an additive agent.

  保湿性和保湿效果持久性优异、使用时触感轻盈、周期稳定性优异的护肤化妆品。此外，所提供的护肤化妆品在使用后不会产生粘腻感，在改善和防止皮肤粗糙、防止和改善皱纹、改善皮肤粗糙度等方面效果优异，还具有使皮肤光滑、有活力的效果。此外，在皮肤清洁组合物中，它们还能发挥这样的效果，即在清洗后能使皮肤充满活力和湿润，并能有效去除附着在手和皮肤上的腥味和氨味或类似的污秽气味。一种皮肤化妆品，其特征在于它含有 (A) 至少一种选自胡颓子科莸属植物的种子萃取物和种壳萃取物的物质，其含量为固体物质重量的 0.00005 至 2%，以及 (B) 一种添加剂。
• THE USE OF RETINOIDS AND MINOXIDIL (2,4-DIAMINO-6-PIPERIDINO-PYRIMIDINE-3-OXIDE) TO INCREASE THE RATE OF GROWTH OF HUMAN SCALP HAIR AND TO TREAT CERTAIN TYPES OF ALOPECIAS
  申请人：BAZZANO, Gail S

  公开号：EP0093770B1

  公开（公告）日：1991-06-19
• DERMAL FILLER HYDROGELS WITH VITAMIN A/CYCLODEXTRIN INCLUSION COMPLEXES
  申请人：ALLERGAN, INC.

  公开号：EP2903588A2

  公开（公告）日：2015-08-12
• US5830760A
  申请人：——

  公开号：US5830760A

  公开（公告）日：1998-11-03
• [EN] TOPICAL PHARMACEUTICAL COMPOSITIONS<br/>[FR] COMPOSITIONS PHARMACEUTIQUES TOPIQUES
  申请人：THE UPJOHN COMPANY

  公开号：WO1994007478A1

  公开（公告）日：1994-04-14

  (EN) The present invention provides topical, non-aqueous pharmaceutical compositions containing about 10 % to about 80 % W/W of a pharmaceutically acceptable noncomedogenic cosmetic oil and ethanol or isopropanol. The compositions provided for improved stability and delivery of the drug to the site of action (e.g. hair follicle and sebaceous gland) without excessive greasiness and/or untoward drying effects. The compositions are also provided for an anti-inflammatory effect and reduced irritation when clindamycin is used in combination with retinoids. The topical pharmaceutical compositions of the present invention can optionally contain propylene glycol and/or polyethylene glycol and/or a pharmaceutically acceptable organic amine. In addition, the topical pharmaceutical compositions of the present invention can optionally be gelled with suitable gelling agents, including for example hydroxypropylcellulose.(FR) L'invention concerne des compositions pharmaceutiques topiques, non aqueuses contenant environ 10 % à 80 % en poids d'une huile cosmétique pharmaceutiquement acceptable et non comédogène, ainsi que de l'éthanol ou de l'isopropanol. Ces compositions permettent d'améliorer la stabilité du médicament et sa libération à l'endroit du traitement (par exemple, follicule pileux et glandes sébacées) sans viscosité excessive et/ou effets desséchants défavorables. Ces compositions exercent également un effet anti-inflammatoire et limitent l'irritation quand on utilise de la clindamycine combinée à des rétinoïdes. Les compositions pharmaceutiques topiques décrites par l'invention peuvent éventuellement contenir du propylène-glycol et/ou du polyéthylène glycol et/ou une amine organique pharmaceutiquement acceptable. De plus, ces compositions peuvent être éventuellement gélifiées au moyen d'agents de gélification appropriés, y compris, par exemple, l'hydroxypropylcellulose.