6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1-methyl-4-(5-methyl-thiophen-2-yl)-1H-quinolin-2-one | 594818-51-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1-methyl-4-(5-methyl-thiophen-2-yl)-1H-quinolin-2-one
• 英文别名: 6-[(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-1-methyl-4-(5-methylthiophen-2-yl)quinolin-2-one
• CAS: 594818-51-6
• 化学式: C₂₆H₂₂ClN₃O₂S
• 分子量: 475.999
• InChiKey: PBFWTDLIWZNCDZ-UHFFFAOYSA-N

物化性质

• 沸点：
  683.8±55.0 °C(Predicted)
• 密度：
  1.33±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  86.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1-methyl-4-(5-methyl-thiophen-2-yl)-1H-quinolin-2-one 在 氯化亚砜 、 N2 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成 6-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4-yl)-methyl]-1-methyl-4-(5-methyl-thiophen-2-yl)-1H-quinolin-2-one
  参考文献：
  名称：

  US2003/166675

  摘要：

  公开号：
• 作为产物：
  描述：

  6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(5-methyl-thiophen-2-yl)-1H-quinolin-2-one 、 碘甲烷 在 sodium hydroxide 、 苄基三乙基氯化铵 作用下， 以 四氢呋喃 为溶剂， 生成 6-[(4-chloro-phenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-1-methyl-4-(5-methyl-thiophen-2-yl)-1H-quinolin-2-one
  参考文献：
  名称：

  US2003/166675

  摘要：

  公开号：

文献信息

• Phosphate/sulfate ester compounds and pharmaceutical composition for inhibiting protein interacting NIMA (PIN1)
  申请人：Dagostino Eleanor

  公开号：US20050250742A1

  公开（公告）日：2005-11-10

  Phosphate/sulfate ester compounds that modulate and/or inhibit the activity of protein interacting NIMA (PIN1), and to pharmaceutical compositions containing such compounds are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating disorders characterized by hypertension, inappropriate cell proliferation, infectious diseases, and neurodegenerative brain disorders, by administering effective amounts of such compounds.

  磷酸/硫酸酯化合物能够调节和/或抑制与蛋白质相互作用的NIMA（PIN1）的活性，以及包含此类化合物的药物组合物。本发明还涉及此类化合物和组合物的治疗或预防用途，以及通过施用有效量的此类化合物来治疗表现为高血压、不适当的细胞增殖、感染性疾病和神经退行性脑障碍的方法。
• QUINOLINONE FARNESYL TRANSFERASE INHIBITORS FOR THE TREATMENT OF SYNUCLEINOPATHIES AND OTHER INDICATIONS
  申请人：Lansbury, JR. Peter T.

  公开号：US20090253655A1

  公开（公告）日：2009-10-08

  Novel quinolinone farnesyl transferase inhibitors are provided. These new compounds are useful in the treatment or prevention of synucleinopathies, such as Parkinson's Disease, Diffuse Lewy Body Disease, multiple system atrophy, and disorders of brain iron concentration including pantothenate kinase-associated neurodegeneration (e.g., PANK1), or other neurodegenerative/neurological diseases. Provided compounds are also useful in the treatment of proliferative diseases such as cancer, and in the treatment of neurological diseases, such as cognitive impairment, depression, and anxiety. The treatment including administering to a subject a therapeutically effective amount of an inventive farnesyl transferase inhibitor compound.

  提供了新型喹诺酮法尼西基转移酶抑制剂。这些新化合物在治疗或预防突触核蛋白病（如帕金森病、弥漫性莱维小体病、多系统萎缩和脑铁浓度紊乱疾病，包括泛酰辅酶A激酶相关的神经退行性疾病（例如PANK1）或其他神经退行性/神经系统疾病方面具有用处。提供的化合物还可用于治疗癌症等增生性疾病，以及治疗认知障碍、抑郁症和焦虑等神经系统疾病。治疗包括向受试者施用一种创新的法尼西基转移酶抑制剂化合物的治疗有效剂量。
• Substituted quinolin-2-one derivatives useful as antiproliferative agents
  申请人：——

  公开号：US20030166675A1

  公开（公告）日：2003-09-04

  The present invention relates to compounds of formulas 1 and 2 1 wherein R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , R 8 , R 10 and Z are as defined herein. The present invention also relates to pharmaceutical compositions containing the above compounds and to methods of treating hyperproliferative disorders, such as cancer, in a mammal by administering the above compounds.

  本发明涉及式1和21的化合物，其中R1，R2，R4，R5，R6，R7，R8，R10和Z的定义如本文所述。本发明还涉及含有上述化合物的制药组合物，以及通过给哺乳动物施用上述化合物治疗增殖性疾病，如癌症的方法。
• US6844357B2
  申请人：——

  公开号：US6844357B2

  公开（公告）日：2005-01-18
• US8232402B2
  申请人：——

  公开号：US8232402B2

  公开（公告）日：2012-07-31