4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]aniline | 199114-45-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]aniline
• 英文别名: 3-[2-(4-aminophenoxy)ethyl]-2-ethyl-6-methylpyrimidin-4-one
• CAS: 199114-45-9
• 化学式: C₁₅H₁₉N₃O₂
• 分子量: 273.335
• InChiKey: HHZYJFTZXNAQFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]aniline 、 氢溴酸 、 sodium nitrite 、 丙烯酸乙酯 在 碘化亚铜 丙酮 、 resultant residue 、 乙酸乙酯 、 氨 、 水 、 Sodium sulfate-III 、 crude compound 作用下， 以 丙酮 、 水 为溶剂， 反应 1.67h， 以to yield the tide compound (2.47 g, 55%)的产率得到ethyl 2-bromo-3-[4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]phenyl]propionate
  参考文献：
  名称：

  Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases

  摘要：

  本发明涉及新型抗糖尿病化合物、它们的互变异构体、衍生物、立体异构体、多晶形态、药用盐、药用溶剂化物和含有它们的药用组合物。本发明特别涉及一般式（I）的新型氮杂环戊二酮衍生物及其药用盐、药用溶剂化物和含有它们的药用组合物。

  公开号：

  US06372750B2
• 作为产物：
  描述：

  4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]nitrobenzene 、 氢气 在 钯 1,4-二氧六环 作用下， 以 1,4-二氧六环 为溶剂， 反应 16.0h， 以to yield the title compound (625 mg, 70%)的产率得到4-[2-[2-ethyl-4-methyl-6-oxo-1,6-dihydro-1-pyrimidinyl]ethoxy]aniline
  参考文献：
  名称：

  Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases

  摘要：

  本发明涉及新型抗糖尿病化合物、它们的互变异构体、衍生物、立体异构体、多晶型、药学上可接受的盐、药学上可接受的溶剂和含有它们的药学上可接受的组合物。本发明特别涉及一般式(I)的新型氮杂环己二酮衍生物及其药学上可接受的盐、药学上可接受的溶剂和含有它们的药物组合物。

  公开号：

  US06780992B2

文献信息

• Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
  申请人：Dr. Reddy's Research Foundation

  公开号：US06310069B1

  公开（公告）日：2001-10-30

  The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them.

  本发明涉及新型抗糖尿病化合物及其互变异构体、衍生物、立体异构体、多晶形态、药用可接受盐、药用可接受溶剂和含有它们的药用可接受组合物。本发明特别涉及一般式(I)的新型噁唑烷二酮衍生物及其药用可接受盐、药用可接受溶剂和含有它们的药用组合物。
• Heterocyclic compounds, process for their preparation and pharmaceutical
  申请人：Dr. Reddy's Research Foundation

  公开号：US05885997A1

  公开（公告）日：1999-03-23

  The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. ##STR1##

  本发明涉及新型抗糖尿病化合物，它们的互变异构形式，它们的衍生物，它们的立体异构体，它们的多晶形态，它们的药学上可接受的盐，它们的药学上可接受的溶剂合物以及含有它们的药学上可接受的组合物。本发明特别涉及一般式（I）的新型噁唑烷二酮衍生物，以及它们的药学上可接受的盐、药学上可接受的溶剂和含有它们的药用组合物。
• Novel heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
  申请人：DR. REDDY'S RESEARCH FOUNDATION & REDDY- CHEMINOR, INC.

  公开号：US20010031759A1

  公开（公告）日：2001-10-18

  The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them. 1

  本发明涉及一种新型抗糖尿病化合物，其互变异构体、衍生物、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂化合物以及含有它们的药学上可接受的组合物。本发明特别涉及一种一般式（I）的新型噁唑烷二酮衍生物及其药学上可接受的盐、药学上可接受的溶剂化合物和含有它们的药物组合物。1
• Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
  申请人：Dr. Reddy's Research Foundation

  公开号：US06372750B2

  公开（公告）日：2002-04-16

  The present invention relates to novel antidiabetic compounds, their tautomeric forms, their derivatives, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them This invention particularly relates to novel azolidinedione derivatives of the general formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable solvates and pharmaceutical compositions containing them

  本发明涉及新型抗糖尿病化合物、它们的互变异构体、衍生物、立体异构体、多晶形态、药用盐、药用溶剂化物和含有它们的药用组合物。本发明特别涉及一般式（I）的新型氮杂环戊二酮衍生物及其药用盐、药用溶剂化物和含有它们的药用组合物。
• HETEROCYCLIC COMPOUNDS PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE TREATMENT OF DIABETES AND RELATED DISEASES
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：EP0958296B1

  公开（公告）日：2003-07-30